Dysregulated miR-133a Mediates Loss of Type II Collagen by Directly Targeting Matrix Metalloproteinase 9 (MMP9) in Human Intervertebral Disc Degeneration

STUDY DESIGN.A microRNA (miRNA) study using Solexa sequencing. OBJECTIVE.The purpose of this study was to identify intervertebral disc degeneration (IDD)-specific miRNA expression profile, and to validate its biological function. SUMMARY OF BACKGROUND DATA.Accumulating evidence indicates that miRNAs...

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Veröffentlicht in:	Spine (Philadelphia, Pa. 1976) Pa. 1976), 2016-06, Vol.41 (12), p.E717-E724
Hauptverfasser:	Xu, Yun-qiang, Zhang, Zhen-hui, Zheng, Yong-fa, Feng, Shi-qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Collagen Type II - genetics Collagen Type II - metabolism Female Gene Knockdown Techniques - methods Humans Intervertebral Disc Degeneration - genetics Intervertebral Disc Degeneration - metabolism Male Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase 9 - genetics MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Nucleus Pulposus - metabolism
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