Sequence-Specific Protein Aggregation Generates Defined Protein Knockdowns in Plants

Protein aggregation is determined by short (5–15 amino acids) aggregation-prone regions (APRs) of the polypeptide sequence that self-associate in a specific manner to form β-structured inclusions. Here, we demonstrate that the sequence specificity of APRs can be exploited to selectively knock down p...

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Veröffentlicht in:	Plant physiology (Bethesda) 2016-06, Vol.171 (2), p.773-787
Hauptverfasser:	Betti, Camilla, Vanhoutte, Isabelle, Coutuer, Silvie, De Rycke, Riet, Mishev, Kiril, Vuylsteke, Marnik, Aesaert, Stijn, Rombaut, Debbie, Gallardo, Rodrigo, De Smet, Frederik, Xu, Jie, Van Lijsebettens, Mieke, Van Breusegem, Frank, Inzé, Dirk, Rousseau, Frederic, Schymkowitz, Joost, Russinova, Eugenia
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Arabidopsis - cytology Arabidopsis - genetics Arabidopsis - metabolism Brassinosteroids - metabolism Breakthrough Technologies Gene Expression Gene Expression Regulation, Plant Gene Knockdown Techniques Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Green Fluorescent Proteins Phenotype Plant Proteins - chemistry Plant Proteins - genetics Plant Proteins - metabolism Plants, Genetically Modified Protein Folding Protein Structure, Tertiary Protein Transport Sequence Alignment Signal Transduction Zea mays - cytology Zea mays - genetics Zea mays - metabolism
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