Insights into composition/structure/function relationships of Doxil® gained from “high-sensitivity” differential scanning calorimetry

[Display omitted] Thermotropic behavior of Doxil® and its generic, Lipodox®, was characterized using “high-sensitivity” differential scanning calorimetry (DSC). This is the first report that two distinct endotherms were observed in Doxil and Lipodox upon heating. The first (Tm at 51±2°C) is broad an...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2016-07, Vol.104, p.260-270
Hauptverfasser:	Wei, Xiaohui, Cohen, Rivka, Barenholz, Yechezkel
Format:	Artikel
Sprache:	eng
Schlagworte:	Calorimetry, Differential Scanning Doxorubicin Doxorubicin - analogs & derivatives Doxorubicin - chemistry Doxorubicin - pharmacology DSC Liposomes PLD Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology Structure-Activity Relationship Thermodynamics
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