Hyperhomocysteinemia is associated with vitamin B-12 deficiency: A cross-sectional study in a rural, elderly population of Shanxi China
Objectives To report the association of lifestyle factors and plasma vitamin B-12 with hyperhomocysteinemia in a large sample of men and women living in a region of China where there is an increased risk of NTDs. Design Community-based, cross-sectional study of Lvliang City, Shanxi Province, China....
Gespeichert in:
| Veröffentlicht in: | The Journal of nutrition, health & aging health & aging, 2016-06, Vol.20 (6), p.594-601 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 601 |
|---|---|
| container_issue | 6 |
| container_start_page | 594 |
| container_title | The Journal of nutrition, health & aging |
| container_volume | 20 |
| creator | Zhang, J. Liu, T.-T. Zhang, W. Li, Y. Niu, Xiao-Yuan Fang, Y.-L. Ma, L.-S. Li, C.-X. |
| description | Objectives
To report the association of lifestyle factors and plasma vitamin B-12 with hyperhomocysteinemia in a large sample of men and women living in a region of China where there is an increased risk of NTDs.
Design
Community-based, cross-sectional study of Lvliang City, Shanxi Province, China.
Setting
Hyperhomocysteinemia is an independent risk factor for cardiovascular disease (CVD) and a sensitive marker of vitamin B-12 and folate deficiency.
Participants
A total of 2355 (1044 men and 1311 women) participants born before 1 January 1958 (≥55 years of age) and living in Lvliang City for at least 2 months a year were included.
Measurements
The participants were assessed regarding demographic characteristics, height, weight, as well as having a physical examination and blood sampling for serum cholesterol, total homocysteine (tHcy), folate, and vitamin B12 levels.
Results
The median (25th–75th percentile) tHcy concentration was 21.5 (15.8–33.6)
µ
mol/L in men and 18.0 (13.4–24.8)
µ
mol/L in women. The overall prevalence of hyperhomocysteinemia (tHcy ≥15
µ
mol/L) was 72.6% (84.3% in men and 63.2% in women), inversely correlated with folate (r=–0.230, P=0.006) and vitamin B-12 (r=–0.540, P |
| doi_str_mv | 10.1007/s12603-015-0650-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1795862669</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4098696951</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-3062a761a90647f149d5528c7b6a359ed4e44a2ad29a6658d8eacf56c789b0253</originalsourceid><addsrcrecordid>eNp1kc9u1DAQhyMEoqXwAFyQJS4camo7_sutrAqtVKkH4GzNOhPWVRIHOwHyBH1tst2CEBInj-RvfjP2V1UvOXvLGTNnhQvNasq4okwrRtWj6pgbzag01j5ea2EcNYaZo-pZKbeMSeWsflodCSNMXUt7XN1dLiPmXepTWMqEccA-AomFQCkpRJiwIT_itCPf4wR9HMh7ygVpsI0h4hCWd-SchJxKoQXDFNMAHSnT3CxkZYHkOUN3SrBrMHcLGdM4d7DHSGrJpx0MPyPZ7OIAz6snLXQFXzycJ9WXDxefN5f0-ubj1eb8mgbJ1URrpgUYzcExLU3LpWuUEjaYrYZaOWwkSgkCGuFAa2UbixBapYOxbsuEqk-qN4fcMadvM5bJ97EE7DoYMM3Fc-OU1UJrt6Kv_0Fv05zXB95Tjq-DuVwpfqDufyFj68cce8iL58zvLfmDJb9a8ntLfr_Eq4fkedtj86fjt5YVEAegrFfDV8x_jf5v6i8pCZ0o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1799155214</pqid></control><display><type>article</type><title>Hyperhomocysteinemia is associated with vitamin B-12 deficiency: A cross-sectional study in a rural, elderly population of Shanxi China</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>SpringerLink Journals - AutoHoldings</source><creator>Zhang, J. ; Liu, T.-T. ; Zhang, W. ; Li, Y. ; Niu, Xiao-Yuan ; Fang, Y.-L. ; Ma, L.-S. ; Li, C.-X.</creator><creatorcontrib>Zhang, J. ; Liu, T.-T. ; Zhang, W. ; Li, Y. ; Niu, Xiao-Yuan ; Fang, Y.-L. ; Ma, L.-S. ; Li, C.-X.</creatorcontrib><description>Objectives
To report the association of lifestyle factors and plasma vitamin B-12 with hyperhomocysteinemia in a large sample of men and women living in a region of China where there is an increased risk of NTDs.
Design
Community-based, cross-sectional study of Lvliang City, Shanxi Province, China.
Setting
Hyperhomocysteinemia is an independent risk factor for cardiovascular disease (CVD) and a sensitive marker of vitamin B-12 and folate deficiency.
Participants
A total of 2355 (1044 men and 1311 women) participants born before 1 January 1958 (≥55 years of age) and living in Lvliang City for at least 2 months a year were included.
Measurements
The participants were assessed regarding demographic characteristics, height, weight, as well as having a physical examination and blood sampling for serum cholesterol, total homocysteine (tHcy), folate, and vitamin B12 levels.
Results
The median (25th–75th percentile) tHcy concentration was 21.5 (15.8–33.6)
µ
mol/L in men and 18.0 (13.4–24.8)
µ
mol/L in women. The overall prevalence of hyperhomocysteinemia (tHcy ≥15
µ
mol/L) was 72.6% (84.3% in men and 63.2% in women), inversely correlated with folate (r=–0.230, P=0.006) and vitamin B-12 (r=–0.540, P<0.001), and positively correlated with uric acid (r=0.054, P<0.001). Vitamin B-12 and folate deficiency, older age, and male gender were associated with elevated tHcy; with vitamin B-12 deficiency being the strongest.
Conclusions
Plasma tHcy concentration and hyperhomocysteinemia were significantly higher in this population than in previously studied populations. Vitamin B-12 and folate supplementation, concomitant lifestyle changes such as smoking cessation, and lipid-lowering treatments may help to decrease plasma tHcy concentrations and reduce the CVD risk in this population.</description><identifier>ISSN: 1279-7707</identifier><identifier>EISSN: 1760-4788</identifier><identifier>DOI: 10.1007/s12603-015-0650-5</identifier><identifier>PMID: 27273348</identifier><language>eng</language><publisher>Paris: Springer Paris</publisher><subject>Age ; Aged ; Aging ; Alzheimer's disease ; Birth defects ; Cardiovascular disease ; China - epidemiology ; Cross-Sectional Studies ; Female ; Gender differences ; Geriatrics/Gerontology ; Homocysteine ; Hospitals ; Humans ; Hyperhomocysteinemia - blood ; Hyperhomocysteinemia - etiology ; Lifestyles ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neurosciences ; Nutrition ; Older people ; Plasma ; Population ; Prevalence ; Primary Care Medicine ; Quality of Life Research ; Risk Factors ; Rural areas ; Rural Population ; Stroke ; Towns ; Vitamin B ; Vitamin B 12 Deficiency - blood ; Vitamin B 12 Deficiency - complications ; Vitamin deficiency ; Womens health</subject><ispartof>The Journal of nutrition, health & aging, 2016-06, Vol.20 (6), p.594-601</ispartof><rights>Serdi and Springer-Verlag France 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-3062a761a90647f149d5528c7b6a359ed4e44a2ad29a6658d8eacf56c789b0253</citedby><cites>FETCH-LOGICAL-c415t-3062a761a90647f149d5528c7b6a359ed4e44a2ad29a6658d8eacf56c789b0253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12603-015-0650-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12603-015-0650-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27273348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, J.</creatorcontrib><creatorcontrib>Liu, T.-T.</creatorcontrib><creatorcontrib>Zhang, W.</creatorcontrib><creatorcontrib>Li, Y.</creatorcontrib><creatorcontrib>Niu, Xiao-Yuan</creatorcontrib><creatorcontrib>Fang, Y.-L.</creatorcontrib><creatorcontrib>Ma, L.-S.</creatorcontrib><creatorcontrib>Li, C.-X.</creatorcontrib><title>Hyperhomocysteinemia is associated with vitamin B-12 deficiency: A cross-sectional study in a rural, elderly population of Shanxi China</title><title>The Journal of nutrition, health & aging</title><addtitle>J Nutr Health Aging</addtitle><addtitle>J Nutr Health Aging</addtitle><description>Objectives
To report the association of lifestyle factors and plasma vitamin B-12 with hyperhomocysteinemia in a large sample of men and women living in a region of China where there is an increased risk of NTDs.
Design
Community-based, cross-sectional study of Lvliang City, Shanxi Province, China.
Setting
Hyperhomocysteinemia is an independent risk factor for cardiovascular disease (CVD) and a sensitive marker of vitamin B-12 and folate deficiency.
Participants
A total of 2355 (1044 men and 1311 women) participants born before 1 January 1958 (≥55 years of age) and living in Lvliang City for at least 2 months a year were included.
Measurements
The participants were assessed regarding demographic characteristics, height, weight, as well as having a physical examination and blood sampling for serum cholesterol, total homocysteine (tHcy), folate, and vitamin B12 levels.
Results
The median (25th–75th percentile) tHcy concentration was 21.5 (15.8–33.6)
µ
mol/L in men and 18.0 (13.4–24.8)
µ
mol/L in women. The overall prevalence of hyperhomocysteinemia (tHcy ≥15
µ
mol/L) was 72.6% (84.3% in men and 63.2% in women), inversely correlated with folate (r=–0.230, P=0.006) and vitamin B-12 (r=–0.540, P<0.001), and positively correlated with uric acid (r=0.054, P<0.001). Vitamin B-12 and folate deficiency, older age, and male gender were associated with elevated tHcy; with vitamin B-12 deficiency being the strongest.
Conclusions
Plasma tHcy concentration and hyperhomocysteinemia were significantly higher in this population than in previously studied populations. Vitamin B-12 and folate supplementation, concomitant lifestyle changes such as smoking cessation, and lipid-lowering treatments may help to decrease plasma tHcy concentrations and reduce the CVD risk in this population.</description><subject>Age</subject><subject>Aged</subject><subject>Aging</subject><subject>Alzheimer's disease</subject><subject>Birth defects</subject><subject>Cardiovascular disease</subject><subject>China - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Gender differences</subject><subject>Geriatrics/Gerontology</subject><subject>Homocysteine</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hyperhomocysteinemia - blood</subject><subject>Hyperhomocysteinemia - etiology</subject><subject>Lifestyles</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neurosciences</subject><subject>Nutrition</subject><subject>Older people</subject><subject>Plasma</subject><subject>Population</subject><subject>Prevalence</subject><subject>Primary Care Medicine</subject><subject>Quality of Life Research</subject><subject>Risk Factors</subject><subject>Rural areas</subject><subject>Rural Population</subject><subject>Stroke</subject><subject>Towns</subject><subject>Vitamin B</subject><subject>Vitamin B 12 Deficiency - blood</subject><subject>Vitamin B 12 Deficiency - complications</subject><subject>Vitamin deficiency</subject><subject>Womens health</subject><issn>1279-7707</issn><issn>1760-4788</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc9u1DAQhyMEoqXwAFyQJS4camo7_sutrAqtVKkH4GzNOhPWVRIHOwHyBH1tst2CEBInj-RvfjP2V1UvOXvLGTNnhQvNasq4okwrRtWj6pgbzag01j5ea2EcNYaZo-pZKbeMSeWsflodCSNMXUt7XN1dLiPmXepTWMqEccA-AomFQCkpRJiwIT_itCPf4wR9HMh7ygVpsI0h4hCWd-SchJxKoQXDFNMAHSnT3CxkZYHkOUN3SrBrMHcLGdM4d7DHSGrJpx0MPyPZ7OIAz6snLXQFXzycJ9WXDxefN5f0-ubj1eb8mgbJ1URrpgUYzcExLU3LpWuUEjaYrYZaOWwkSgkCGuFAa2UbixBapYOxbsuEqk-qN4fcMadvM5bJ97EE7DoYMM3Fc-OU1UJrt6Kv_0Fv05zXB95Tjq-DuVwpfqDufyFj68cce8iL58zvLfmDJb9a8ntLfr_Eq4fkedtj86fjt5YVEAegrFfDV8x_jf5v6i8pCZ0o</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Zhang, J.</creator><creator>Liu, T.-T.</creator><creator>Zhang, W.</creator><creator>Li, Y.</creator><creator>Niu, Xiao-Yuan</creator><creator>Fang, Y.-L.</creator><creator>Ma, L.-S.</creator><creator>Li, C.-X.</creator><general>Springer Paris</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160601</creationdate><title>Hyperhomocysteinemia is associated with vitamin B-12 deficiency: A cross-sectional study in a rural, elderly population of Shanxi China</title><author>Zhang, J. ; Liu, T.-T. ; Zhang, W. ; Li, Y. ; Niu, Xiao-Yuan ; Fang, Y.-L. ; Ma, L.-S. ; Li, C.-X.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-3062a761a90647f149d5528c7b6a359ed4e44a2ad29a6658d8eacf56c789b0253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Age</topic><topic>Aged</topic><topic>Aging</topic><topic>Alzheimer's disease</topic><topic>Birth defects</topic><topic>Cardiovascular disease</topic><topic>China - epidemiology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Gender differences</topic><topic>Geriatrics/Gerontology</topic><topic>Homocysteine</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hyperhomocysteinemia - blood</topic><topic>Hyperhomocysteinemia - etiology</topic><topic>Lifestyles</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neurosciences</topic><topic>Nutrition</topic><topic>Older people</topic><topic>Plasma</topic><topic>Population</topic><topic>Prevalence</topic><topic>Primary Care Medicine</topic><topic>Quality of Life Research</topic><topic>Risk Factors</topic><topic>Rural areas</topic><topic>Rural Population</topic><topic>Stroke</topic><topic>Towns</topic><topic>Vitamin B</topic><topic>Vitamin B 12 Deficiency - blood</topic><topic>Vitamin B 12 Deficiency - complications</topic><topic>Vitamin deficiency</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, J.</creatorcontrib><creatorcontrib>Liu, T.-T.</creatorcontrib><creatorcontrib>Zhang, W.</creatorcontrib><creatorcontrib>Li, Y.</creatorcontrib><creatorcontrib>Niu, Xiao-Yuan</creatorcontrib><creatorcontrib>Fang, Y.-L.</creatorcontrib><creatorcontrib>Ma, L.-S.</creatorcontrib><creatorcontrib>Li, C.-X.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition, health & aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, J.</au><au>Liu, T.-T.</au><au>Zhang, W.</au><au>Li, Y.</au><au>Niu, Xiao-Yuan</au><au>Fang, Y.-L.</au><au>Ma, L.-S.</au><au>Li, C.-X.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperhomocysteinemia is associated with vitamin B-12 deficiency: A cross-sectional study in a rural, elderly population of Shanxi China</atitle><jtitle>The Journal of nutrition, health & aging</jtitle><stitle>J Nutr Health Aging</stitle><addtitle>J Nutr Health Aging</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>20</volume><issue>6</issue><spage>594</spage><epage>601</epage><pages>594-601</pages><issn>1279-7707</issn><eissn>1760-4788</eissn><abstract>Objectives
To report the association of lifestyle factors and plasma vitamin B-12 with hyperhomocysteinemia in a large sample of men and women living in a region of China where there is an increased risk of NTDs.
Design
Community-based, cross-sectional study of Lvliang City, Shanxi Province, China.
Setting
Hyperhomocysteinemia is an independent risk factor for cardiovascular disease (CVD) and a sensitive marker of vitamin B-12 and folate deficiency.
Participants
A total of 2355 (1044 men and 1311 women) participants born before 1 January 1958 (≥55 years of age) and living in Lvliang City for at least 2 months a year were included.
Measurements
The participants were assessed regarding demographic characteristics, height, weight, as well as having a physical examination and blood sampling for serum cholesterol, total homocysteine (tHcy), folate, and vitamin B12 levels.
Results
The median (25th–75th percentile) tHcy concentration was 21.5 (15.8–33.6)
µ
mol/L in men and 18.0 (13.4–24.8)
µ
mol/L in women. The overall prevalence of hyperhomocysteinemia (tHcy ≥15
µ
mol/L) was 72.6% (84.3% in men and 63.2% in women), inversely correlated with folate (r=–0.230, P=0.006) and vitamin B-12 (r=–0.540, P<0.001), and positively correlated with uric acid (r=0.054, P<0.001). Vitamin B-12 and folate deficiency, older age, and male gender were associated with elevated tHcy; with vitamin B-12 deficiency being the strongest.
Conclusions
Plasma tHcy concentration and hyperhomocysteinemia were significantly higher in this population than in previously studied populations. Vitamin B-12 and folate supplementation, concomitant lifestyle changes such as smoking cessation, and lipid-lowering treatments may help to decrease plasma tHcy concentrations and reduce the CVD risk in this population.</abstract><cop>Paris</cop><pub>Springer Paris</pub><pmid>27273348</pmid><doi>10.1007/s12603-015-0650-5</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1279-7707 |
| ispartof | The Journal of nutrition, health & aging, 2016-06, Vol.20 (6), p.594-601 |
| issn | 1279-7707 1760-4788 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1795862669 |
| source | MEDLINE; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Age Aged Aging Alzheimer's disease Birth defects Cardiovascular disease China - epidemiology Cross-Sectional Studies Female Gender differences Geriatrics/Gerontology Homocysteine Hospitals Humans Hyperhomocysteinemia - blood Hyperhomocysteinemia - etiology Lifestyles Male Medicine Medicine & Public Health Middle Aged Neurosciences Nutrition Older people Plasma Population Prevalence Primary Care Medicine Quality of Life Research Risk Factors Rural areas Rural Population Stroke Towns Vitamin B Vitamin B 12 Deficiency - blood Vitamin B 12 Deficiency - complications Vitamin deficiency Womens health |
| title | Hyperhomocysteinemia is associated with vitamin B-12 deficiency: A cross-sectional study in a rural, elderly population of Shanxi China |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T21%3A29%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hyperhomocysteinemia%20is%20associated%20with%20vitamin%20B-12%20deficiency:%20A%20cross-sectional%20study%20in%20a%20rural,%20elderly%20population%20of%20Shanxi%20China&rft.jtitle=The%20Journal%20of%20nutrition,%20health%20&%20aging&rft.au=Zhang,%20J.&rft.date=2016-06-01&rft.volume=20&rft.issue=6&rft.spage=594&rft.epage=601&rft.pages=594-601&rft.issn=1279-7707&rft.eissn=1760-4788&rft_id=info:doi/10.1007/s12603-015-0650-5&rft_dat=%3Cproquest_cross%3E4098696951%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1799155214&rft_id=info:pmid/27273348&rfr_iscdi=true |