Mutations in CD46, a complement regulatory protein, predispose to atypical HUS

Membrane cofactor protein (MCP, CD46) is a widely expressed transmembrane complement regulator. As does the soluble regulator factor H, it inhibits complement activation by inactivating the C3b that is deposited on target membranes. Factor H mutations have been described in 15-30% of patients with a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Trends in molecular medicine 2004-05, Vol.10 (5), p.226-231
Hauptverfasser:	Goodship, Timothy H J, Liszewski, M Kathryn, Kemp, Elizabeth J, Richards, Anna, Atkinson, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Membrane - immunology Codon, Nonsense Complement Activation - genetics Complement C3b - metabolism Complement Factor H - genetics Genetic Predisposition to Disease Hemolytic-Uremic Syndrome - genetics Hemolytic-Uremic Syndrome - immunology Heterozygote Humans Membrane Cofactor Protein - genetics Membrane Cofactor Protein - metabolism Mutation Phenotype Risk Factors Sequence Deletion
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!