Modulation of N-methyl-N-nitrosourea-induced crypt restricted metallothionein immunopositivity in mouse colon by a non-genotoxic diet-related chemical

Red meat consumption is associated with endogenous metabolic generation of mutagenic N-nitroso compounds (NOC) and may be implicated in causation of colorectal cancer. Assessment of a biologically relevant dose of NOCs is hampered by imperfect understanding of NOC interactions with other dietary com...

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Veröffentlicht in:	Carcinogenesis (New York) 2004-05, Vol.25 (5), p.847-855
Hauptverfasser:	Donnelly, Eilish T., Bardwell, Helen, Thomas, Geraldine Anne, Williams, E. Dillwyn, Hoper, Margaret, Crowe, Paul, McCluggage, Wilson G., Stevenson, Michael, Phillips, David H., Hewer, Alan, Osborne, Martin R., Campbell, Frederick C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents - toxicity Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carrageenan - toxicity Colon - drug effects Colon - metabolism Colonic Neoplasms - chemically induced Diet dimethylhydrazine dimethylsulphoxide DMH DMSO DNA - drug effects DNA - metabolism DNA Adducts Drug Combinations ENU Feces - chemistry Female G6PD glucose 6-phosphate dehydrogenase Medical sciences metallothionein Metallothionein - immunology Metallothionein - metabolism Methylnitrosourea - toxicity Mice Mice, Inbred BALB C MNU N-ethyl-N-nitrosourea N-methyl-N-nitrosourea Stem Cells - drug effects Stem Cells - metabolism Tumors λ carrageenan λCgN
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