Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehydrogenase: possible reason for its toxicity

From our previous study [Eur. J. Clin. Pharmacol. 56 (2000) 405] we hypothesized that chloramphenicol succinate (CAPS) may be a competitive substrate for succinate dehydrogenase (SDH). It may be oxidized by SDH to release chloramphenicol (CAP), which may inhibit SDH by feed back mechanism. The prese...

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Veröffentlicht in:	Toxicology in vitro 2004-08, Vol.18 (4), p.441-447
Hauptverfasser:	Ambekar, C.S., Lee, J.S.K., Cheung, B.M.Y., Chan, L.C., Liang, R., Kumana, C.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow - drug effects Bone Marrow - physiology Chloramphenicol - analogs & derivatives Chloramphenicol - analysis Chloramphenicol - pharmacology Chloramphenicol - toxicity Chloramphenicol succinate Chromatography, High Pressure Liquid Human bone marrow and liver Humans In Vitro Techniques Kidney - drug effects Kidney - physiology Liver - drug effects Liver - physiology Metabolism Mitochondria - drug effects Mitochondria - physiology Oxidation-Reduction Oxidative Stress Protein Synthesis Inhibitors - analysis Rat liver and kidney mitochondria Rats Succinate dehydrogenase Succinate Dehydrogenase - antagonists & inhibitors Succinate Dehydrogenase - pharmacology
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