Protein Ranking: From Local to Global Structure in the Protein Similarity Network

Biologists regularly search databases of DNA or protein sequences for evolutionary or functional relationships to a given query sequence. We describe a ranking algorithm that exploits the entire network structure of similarity relationships among proteins in a sequence database by performing a diffu...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-04, Vol.101 (17), p.6559-6563
Hauptverfasser:	Weston, Jason, Elisseeff, Andre, Zhou, Dengyong, Leslie, Christina S., Noble, William Stafford, Waterman, Michael S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biological Sciences Blasts Databases, Nucleic Acid Databases, Protein Deoxyribonucleic acid DNA Evolution Genetics Gold standard Graph theory Hyperlinks Protein Conformation Proteins Proteins - chemistry Proteins - genetics Search engines Statistical significance
Online-Zugang:	Volltext
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