TAZ Interacts with TTF-1 and Regulates Expression of Surfactant Protein-C

Thyroid transcription factor-1 (TTF-1/Nkx-2.1) is required for formation of the lung and differentiation of peripheral respiratory epithelial cells. TTF-1 activates transcription of target genes, including the surfactant proteins critical for lung function. A recently identified protein TAZ (transcr...

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Veröffentlicht in:	The Journal of biological chemistry 2004-04, Vol.279 (17), p.17384-17390
Hauptverfasser:	Park, Kwon-Sik, Whitsett, Jeffrey A., Di Palma, Tina, Hong, Jeong-Ho, Yaffe, Michael B., Zannini, Mariastella
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Cells, Cultured Epithelial Cells - metabolism Epithelium - metabolism Gene Deletion Gene Expression Regulation Genes, Reporter Glutathione Transferase - metabolism HeLa Cells Humans Immunohistochemistry In Situ Hybridization Intercellular Signaling Peptides and Proteins Lung - cytology Lung - embryology Lung - metabolism Mice Models, Biological Nuclear Proteins - chemistry Nuclear Proteins - metabolism Peptides - chemistry Peptides - metabolism Plasmids - metabolism Promoter Regions, Genetic Protein Binding Protein Structure, Tertiary Proteins - chemistry Proteins - metabolism Pulmonary Surfactant-Associated Protein C Reverse Transcriptase Polymerase Chain Reaction RNA - metabolism RNA, Messenger - metabolism Thyroid Nuclear Factor 1 Transcription Factors - chemistry Transcription Factors - metabolism Transcription, Genetic Transcriptional Activation Transfection Two-Hybrid System Techniques
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