Mutations in the Extracellular Domain and in the Membrane-Spanning Domains Interfere with Nicotinic Acetylcholine Receptor Maturation

The deg-3(u662) mutation is a degeneration-causing mutation in a Caenorhabditis elegans nicotinic acetylcholine receptor. In a large screen for mutations that suppress the deleterious effects of this mutation we identified 32 mutations in the deg-3 gene. Among these, 11 are missense mutations, affec...

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