Vitamin C Suppresses TNFα-Induced NFκB Activation by Inhibiting IκBα Phosphorylation

Extracellular stimuli signal for activation of the transcription factor NFκB, leading to gene expression regulating processes involved in immune responses, inflammation, and cell survival. Tumor necrosis factor-α (TNFα) activates NFκB via a well-defined kinase pathways involving NFκB-inducing kinase...

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Veröffentlicht in:	Biochemistry (Easton) 2002-10, Vol.41 (43), p.12995-13002
Hauptverfasser:	Cárcamo, Juan M, Pedraza, Alicia, Bórquez-Ojeda, Oriana, Golde, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Active Transport, Cell Nucleus - physiology Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antioxidants - pharmacology Ascorbic Acid - pharmacology Cell Line Cell Nucleus - drug effects Cell Nucleus - metabolism Enzyme Activation - drug effects Enzyme Activation - physiology HeLa Cells HL-60 Cells Humans I-kappa B Kinase I-kappa B Proteins - antagonists & inhibitors I-kappa B Proteins - metabolism Mitogen-Activated Protein Kinases - metabolism NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-KappaB Inhibitor alpha NF-kappaB-Inducing Kinase p38 Mitogen-Activated Protein Kinases Phosphorylation - drug effects Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - metabolism Transcriptional Activation - drug effects Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - physiology U937 Cells
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