Mice Deficient in 11β-Hydroxysteroid Dehydrogenase Type 1 Lack Bone Marrow Adipocytes, but Maintain Normal Bone Formation

Glucocorticoids (GCs) exert potent, but poorly characterized, effects on the skeleton. The cellular activity of GCs is regulated at a prereceptor level by 11β-hydroxysteroid dehydrogenases (11βHSDs). The type 1 isoform, which predominates in bone, functions as a reductase in intact cells and regener...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2004-04, Vol.145 (4), p.1916-1925
Hauptverfasser:	Justesen, Jeannette, Mosekilde, Lis, Holmes, Megan, Stenderup, Karin, Gasser, Jürg, Mullins, John J, Seckl, Jonathan R, Kassem, Moustapha
Format:	Artikel
Sprache:	eng
Schlagworte:	11β-Hydroxysteroid dehydrogenase Adipocytes Age Biological and medical sciences Bone composition Bone growth Bone loss Bone marrow Bone mass Bone resorption Cancellous bone Cortical bone Corticosterone Fundamental and applied biological sciences. Psychology Glucocorticoids Hydroxysteroids In vivo methods and tests Osteoblasts Osteogenesis Reductases Skeleton Stromal cells Vertebrates: endocrinology
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