Hepatitis C Virus (HCV) Reactivation Caused by Steroid Therapy for Dermatomyositis
A Japanese woman was treated with injectable methylprednisolone and oral prednisolone for dermatomyositis. On admission, her serum was positive for anti-hepatitis C virus (HCV) antibodies, although HCV RNA was undetectable on polymerase chain reaction. Glucocorticoid therapy improved the dermatomyos...
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| Veröffentlicht in: | Internal Medicine 2014, Vol.53(23), pp.2689-2693 |
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| creator | Mori, Nami Imamura, Michio Takaki, Shintaro Araki, Takehisa Hayes, Nelson C. Aisaka, Yasuyuki Chayama, Kazuaki |
| description | A Japanese woman was treated with injectable methylprednisolone and oral prednisolone for dermatomyositis. On admission, her serum was positive for anti-hepatitis C virus (HCV) antibodies, although HCV RNA was undetectable on polymerase chain reaction. Glucocorticoid therapy improved the dermatomyositis; however, the serum alanine aminotransferase levels rapidly increased, with positive serum HCV RNA and a high viral titer. Both parameters decreased in association with prednisolone tapering, whereas dermatomyositis subsequently recurred and the administration of glucocorticoid therapy was repeated. The serum alanine aminotransferase and HCV RNA levels subsequently increased in a similar manner to that observed after the first course of therapy. Liver enzymes and the viral load should be monitored in anti-HCV-positive patients receiving immunosuppressives, even if serum HCV RNA is negative. |
| doi_str_mv | 10.2169/internalmedicine.53.3194 |
| format | Article |
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On admission, her serum was positive for anti-hepatitis C virus (HCV) antibodies, although HCV RNA was undetectable on polymerase chain reaction. Glucocorticoid therapy improved the dermatomyositis; however, the serum alanine aminotransferase levels rapidly increased, with positive serum HCV RNA and a high viral titer. Both parameters decreased in association with prednisolone tapering, whereas dermatomyositis subsequently recurred and the administration of glucocorticoid therapy was repeated. The serum alanine aminotransferase and HCV RNA levels subsequently increased in a similar manner to that observed after the first course of therapy. Liver enzymes and the viral load should be monitored in anti-HCV-positive patients receiving immunosuppressives, even if serum HCV RNA is negative.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.53.3194</identifier><identifier>PMID: 25447651</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Aged ; Alanine Transaminase - blood ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - adverse effects ; Dermatomyositis - drug therapy ; Female ; Hepacivirus - genetics ; Hepacivirus - immunology ; Hepacivirus - isolation & purification ; Hepatitis C - diagnosis ; Hepatitis C - genetics ; Hepatitis C - immunology ; Hepatitis C Antibodies - blood ; Hepatitis C virus ; Humans ; methylprednisolone ; myositis ; Polymerase Chain Reaction ; Prednisolone - administration & dosage ; Prednisolone - adverse effects ; reactivation ; RNA, Viral - blood ; steroids ; Treatment Outcome ; Virus Activation ; Virus Latency</subject><ispartof>Internal Medicine, 2014, Vol.53(23), pp.2689-2693</ispartof><rights>2014 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c617t-224a74836070b52bde10df7f9a3cf78c40db0d8235e777cd887d8cb1631f635d3</citedby><cites>FETCH-LOGICAL-c617t-224a74836070b52bde10df7f9a3cf78c40db0d8235e777cd887d8cb1631f635d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25447651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mori, Nami</creatorcontrib><creatorcontrib>Imamura, Michio</creatorcontrib><creatorcontrib>Takaki, Shintaro</creatorcontrib><creatorcontrib>Araki, Takehisa</creatorcontrib><creatorcontrib>Hayes, Nelson C.</creatorcontrib><creatorcontrib>Aisaka, Yasuyuki</creatorcontrib><creatorcontrib>Chayama, Kazuaki</creatorcontrib><title>Hepatitis C Virus (HCV) Reactivation Caused by Steroid Therapy for Dermatomyositis</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A Japanese woman was treated with injectable methylprednisolone and oral prednisolone for dermatomyositis. On admission, her serum was positive for anti-hepatitis C virus (HCV) antibodies, although HCV RNA was undetectable on polymerase chain reaction. Glucocorticoid therapy improved the dermatomyositis; however, the serum alanine aminotransferase levels rapidly increased, with positive serum HCV RNA and a high viral titer. Both parameters decreased in association with prednisolone tapering, whereas dermatomyositis subsequently recurred and the administration of glucocorticoid therapy was repeated. The serum alanine aminotransferase and HCV RNA levels subsequently increased in a similar manner to that observed after the first course of therapy. Liver enzymes and the viral load should be monitored in anti-HCV-positive patients receiving immunosuppressives, even if serum HCV RNA is negative.</description><subject>Aged</subject><subject>Alanine Transaminase - blood</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - adverse effects</subject><subject>Dermatomyositis - drug therapy</subject><subject>Female</subject><subject>Hepacivirus - genetics</subject><subject>Hepacivirus - immunology</subject><subject>Hepacivirus - isolation & purification</subject><subject>Hepatitis C - diagnosis</subject><subject>Hepatitis C - genetics</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C Antibodies - blood</subject><subject>Hepatitis C virus</subject><subject>Humans</subject><subject>methylprednisolone</subject><subject>myositis</subject><subject>Polymerase Chain Reaction</subject><subject>Prednisolone - administration & dosage</subject><subject>Prednisolone - adverse effects</subject><subject>reactivation</subject><subject>RNA, Viral - blood</subject><subject>steroids</subject><subject>Treatment Outcome</subject><subject>Virus Activation</subject><subject>Virus Latency</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtrHDEQhIVJiDdO_kLQ0TnMRs-RdAyTOGswGBzHV6GRemKZeWykmcD-e2vZ9R6CIZfuQ39dRRVCmJI1o7X5EscZ0uj6AUL0cYS15GtOjThDK8qFqRTj8g1aEUN1xco4R-9zfiKEa2XYO3TOpBCqlnSF7jawdXOcY8YNfohpyfhy0zx8xnfg_Bz_lts04sYtGQJud_hnMZ5iwPePkNx2h7sp4W-QBjdPw27Ke6EP6G3n-gwfj_sC_br6ft9sqpvbH9fN15vK11TNFWPCKaF5TRRpJWsDUBI61RnHfae0FyS0JOiSBJRSPmitgvYtrTntai4Dv0CXB91tmv4skGc7xOyh790I05ItVUZIQkv8_6M1M0aaWtCC6gPq05Rzgs5uUxxc2llK7L58-2_5VnK7L7-8fjq6LG05nh5f2i7A7QF4yrP7DSfApTn6Hl5VZnw_jxYn0j-6ZGHkz0j0oes</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Mori, Nami</creator><creator>Imamura, Michio</creator><creator>Takaki, Shintaro</creator><creator>Araki, Takehisa</creator><creator>Hayes, Nelson C.</creator><creator>Aisaka, Yasuyuki</creator><creator>Chayama, Kazuaki</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20140101</creationdate><title>Hepatitis C Virus (HCV) Reactivation Caused by Steroid Therapy for Dermatomyositis</title><author>Mori, Nami ; Imamura, Michio ; Takaki, Shintaro ; Araki, Takehisa ; Hayes, Nelson C. ; Aisaka, Yasuyuki ; Chayama, Kazuaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c617t-224a74836070b52bde10df7f9a3cf78c40db0d8235e777cd887d8cb1631f635d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Alanine Transaminase - blood</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Anti-Inflammatory Agents - adverse effects</topic><topic>Dermatomyositis - drug therapy</topic><topic>Female</topic><topic>Hepacivirus - genetics</topic><topic>Hepacivirus - immunology</topic><topic>Hepacivirus - isolation & purification</topic><topic>Hepatitis C - diagnosis</topic><topic>Hepatitis C - genetics</topic><topic>Hepatitis C - immunology</topic><topic>Hepatitis C Antibodies - blood</topic><topic>Hepatitis C virus</topic><topic>Humans</topic><topic>methylprednisolone</topic><topic>myositis</topic><topic>Polymerase Chain Reaction</topic><topic>Prednisolone - administration & dosage</topic><topic>Prednisolone - adverse effects</topic><topic>reactivation</topic><topic>RNA, Viral - blood</topic><topic>steroids</topic><topic>Treatment Outcome</topic><topic>Virus Activation</topic><topic>Virus Latency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mori, Nami</creatorcontrib><creatorcontrib>Imamura, Michio</creatorcontrib><creatorcontrib>Takaki, Shintaro</creatorcontrib><creatorcontrib>Araki, Takehisa</creatorcontrib><creatorcontrib>Hayes, Nelson C.</creatorcontrib><creatorcontrib>Aisaka, Yasuyuki</creatorcontrib><creatorcontrib>Chayama, Kazuaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mori, Nami</au><au>Imamura, Michio</au><au>Takaki, Shintaro</au><au>Araki, Takehisa</au><au>Hayes, Nelson C.</au><au>Aisaka, Yasuyuki</au><au>Chayama, Kazuaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis C Virus (HCV) Reactivation Caused by Steroid Therapy for Dermatomyositis</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>53</volume><issue>23</issue><spage>2689</spage><epage>2693</epage><pages>2689-2693</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>A Japanese woman was treated with injectable methylprednisolone and oral prednisolone for dermatomyositis. On admission, her serum was positive for anti-hepatitis C virus (HCV) antibodies, although HCV RNA was undetectable on polymerase chain reaction. Glucocorticoid therapy improved the dermatomyositis; however, the serum alanine aminotransferase levels rapidly increased, with positive serum HCV RNA and a high viral titer. Both parameters decreased in association with prednisolone tapering, whereas dermatomyositis subsequently recurred and the administration of glucocorticoid therapy was repeated. The serum alanine aminotransferase and HCV RNA levels subsequently increased in a similar manner to that observed after the first course of therapy. Liver enzymes and the viral load should be monitored in anti-HCV-positive patients receiving immunosuppressives, even if serum HCV RNA is negative.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>25447651</pmid><doi>10.2169/internalmedicine.53.3194</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Alanine Transaminase - blood Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - adverse effects Dermatomyositis - drug therapy Female Hepacivirus - genetics Hepacivirus - immunology Hepacivirus - isolation & purification Hepatitis C - diagnosis Hepatitis C - genetics Hepatitis C - immunology Hepatitis C Antibodies - blood Hepatitis C virus Humans methylprednisolone myositis Polymerase Chain Reaction Prednisolone - administration & dosage Prednisolone - adverse effects reactivation RNA, Viral - blood steroids Treatment Outcome Virus Activation Virus Latency |
| title | Hepatitis C Virus (HCV) Reactivation Caused by Steroid Therapy for Dermatomyositis |
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