Gamma Heavy Chain Disease with T-cell Large Granular Lymphocytic Leukemia: A Case Report and Review of the Literature
Gamma heavy chain disease (gHCD) is a rare lymphoproliferative disorder characterized by the production of a truncated immunoglobulin heavy chain. Although some cases of gHCD are concurrent with other lymphoid neoplasms, few have been reported. We herein present the case of a 73-year-old woman with...
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| Veröffentlicht in: | Internal Medicine 2016, Vol.55(4), pp.399-403 |
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| container_title | Internal Medicine |
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| creator | Iijima, Masahide Sekiguchi, Naohiro Nagata, Akihisa Wagatsuma, Miyuki Midorikawa, Kiyoe Kurimoto, Miwa Noto, Satoshi Yamada, Kazuaki Takezako, Naoki |
| description | Gamma heavy chain disease (gHCD) is a rare lymphoproliferative disorder characterized by the production of a truncated immunoglobulin heavy chain. Although some cases of gHCD are concurrent with other lymphoid neoplasms, few have been reported. We herein present the case of a 73-year-old woman with gHCD and T-cell large granular lymphocytic leukemia. A multiparameter flow cytometry analysis revealed neoplastic cells that were positive for CD28, a marker of T-cell activation, the anti-apoptotic antigen of neoplastic plasma cells, CD38 and CD45. The results of this multiparameter flow cytometry analysis may contribute to furthering the understanding of the clinicopathological features of gHCD. |
| doi_str_mv | 10.2169/internalmedicine.55.5042 |
| format | Article |
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Although some cases of gHCD are concurrent with other lymphoid neoplasms, few have been reported. We herein present the case of a 73-year-old woman with gHCD and T-cell large granular lymphocytic leukemia. A multiparameter flow cytometry analysis revealed neoplastic cells that were positive for CD28, a marker of T-cell activation, the anti-apoptotic antigen of neoplastic plasma cells, CD38 and CD45. The results of this multiparameter flow cytometry analysis may contribute to furthering the understanding of the clinicopathological features of gHCD.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.55.5042</identifier><identifier>PMID: 26875967</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Aged ; Anemia - etiology ; Anemia - immunology ; composite lymphoid malignancy ; Cytogenetic Analysis ; Fatigue - etiology ; Fatigue - immunology ; Female ; Flow Cytometry ; gamma heavy chain disease ; Heavy Chain Disease - complications ; Heavy Chain Disease - immunology ; Heavy Chain Disease - pathology ; Humans ; Immunoglobulin gamma-Chains - blood ; Immunoglobulin gamma-Chains - metabolism ; Immunoglobulin Heavy Chains ; Leukemia, Large Granular Lymphocytic - complications ; Leukemia, Large Granular Lymphocytic - immunology ; Leukemia, Large Granular Lymphocytic - pathology ; Lymphocytes - metabolism ; multiparameter flow cytometry analysis ; T-cell large granular lymphocytic leukemia</subject><ispartof>Internal Medicine, 2016, Vol.55(4), pp.399-403</ispartof><rights>2016 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c559t-b37817137058e76e107424c2844a173abaeaeeb7a99577bd37324ffea39753f33</citedby><cites>FETCH-LOGICAL-c559t-b37817137058e76e107424c2844a173abaeaeeb7a99577bd37324ffea39753f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26875967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iijima, Masahide</creatorcontrib><creatorcontrib>Sekiguchi, Naohiro</creatorcontrib><creatorcontrib>Nagata, Akihisa</creatorcontrib><creatorcontrib>Wagatsuma, Miyuki</creatorcontrib><creatorcontrib>Midorikawa, Kiyoe</creatorcontrib><creatorcontrib>Kurimoto, Miwa</creatorcontrib><creatorcontrib>Noto, Satoshi</creatorcontrib><creatorcontrib>Yamada, Kazuaki</creatorcontrib><creatorcontrib>Takezako, Naoki</creatorcontrib><title>Gamma Heavy Chain Disease with T-cell Large Granular Lymphocytic Leukemia: A Case Report and Review of the Literature</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Gamma heavy chain disease (gHCD) is a rare lymphoproliferative disorder characterized by the production of a truncated immunoglobulin heavy chain. Although some cases of gHCD are concurrent with other lymphoid neoplasms, few have been reported. We herein present the case of a 73-year-old woman with gHCD and T-cell large granular lymphocytic leukemia. A multiparameter flow cytometry analysis revealed neoplastic cells that were positive for CD28, a marker of T-cell activation, the anti-apoptotic antigen of neoplastic plasma cells, CD38 and CD45. The results of this multiparameter flow cytometry analysis may contribute to furthering the understanding of the clinicopathological features of gHCD.</description><subject>Aged</subject><subject>Anemia - etiology</subject><subject>Anemia - immunology</subject><subject>composite lymphoid malignancy</subject><subject>Cytogenetic Analysis</subject><subject>Fatigue - etiology</subject><subject>Fatigue - immunology</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>gamma heavy chain disease</subject><subject>Heavy Chain Disease - complications</subject><subject>Heavy Chain Disease - immunology</subject><subject>Heavy Chain Disease - pathology</subject><subject>Humans</subject><subject>Immunoglobulin gamma-Chains - blood</subject><subject>Immunoglobulin gamma-Chains - metabolism</subject><subject>Immunoglobulin Heavy Chains</subject><subject>Leukemia, Large Granular Lymphocytic - complications</subject><subject>Leukemia, Large Granular Lymphocytic - immunology</subject><subject>Leukemia, Large Granular Lymphocytic - pathology</subject><subject>Lymphocytes - metabolism</subject><subject>multiparameter flow cytometry analysis</subject><subject>T-cell large granular lymphocytic leukemia</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhS0EokPhLyAv2WTwM47ZVUOZIkUgobK2bjI3jUseg-20mn-PhymzQEhsbEv-zjnXPoRQztaCl_a9nxKGCYYRd771E661XmumxDOy4lLZwgipn5MVs7wqRF4uyKsY7xmTlbHiJbkQZWW0Lc2KLFsYR6A3CA8HuunBT_SjjwgR6aNPPb0tWhwGWkO4Q7oNMC0DBFofxn0_t4fkW1rj8gNHDx_oFd0cdd9wP4dEYdrl44PHRzp3NPVIa5-nhrQEfE1edDBEfPO0X5Lvn65vNzdF_XX7eXNVF63WNhWNNBU3XBqmKzQlcmaUUK2olAJuJDSAgNgYsFYb0-ykkUJ1HYK0RstOykvy7uS7D_PPBWNyo4_HB8GE8xIdN1ZpxnXO-D9aam2slTaj1QltwxxjwM7tgx8hHBxn7tiP-7sfp7U79pOlb59SliZfnoV_CsnAlxNwHxPc4RmAkP96wH86q9_2p4Qz2PYQHE7yF8WJrXo</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Iijima, Masahide</creator><creator>Sekiguchi, Naohiro</creator><creator>Nagata, Akihisa</creator><creator>Wagatsuma, Miyuki</creator><creator>Midorikawa, Kiyoe</creator><creator>Kurimoto, Miwa</creator><creator>Noto, Satoshi</creator><creator>Yamada, Kazuaki</creator><creator>Takezako, Naoki</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20160101</creationdate><title>Gamma Heavy Chain Disease with T-cell Large Granular Lymphocytic Leukemia: A Case Report and Review of the Literature</title><author>Iijima, Masahide ; Sekiguchi, Naohiro ; Nagata, Akihisa ; Wagatsuma, Miyuki ; Midorikawa, Kiyoe ; Kurimoto, Miwa ; Noto, Satoshi ; Yamada, Kazuaki ; Takezako, Naoki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c559t-b37817137058e76e107424c2844a173abaeaeeb7a99577bd37324ffea39753f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Anemia - etiology</topic><topic>Anemia - immunology</topic><topic>composite lymphoid malignancy</topic><topic>Cytogenetic Analysis</topic><topic>Fatigue - etiology</topic><topic>Fatigue - immunology</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>gamma heavy chain disease</topic><topic>Heavy Chain Disease - complications</topic><topic>Heavy Chain Disease - immunology</topic><topic>Heavy Chain Disease - pathology</topic><topic>Humans</topic><topic>Immunoglobulin gamma-Chains - blood</topic><topic>Immunoglobulin gamma-Chains - metabolism</topic><topic>Immunoglobulin Heavy Chains</topic><topic>Leukemia, Large Granular Lymphocytic - complications</topic><topic>Leukemia, Large Granular Lymphocytic - immunology</topic><topic>Leukemia, Large Granular Lymphocytic - pathology</topic><topic>Lymphocytes - metabolism</topic><topic>multiparameter flow cytometry analysis</topic><topic>T-cell large granular lymphocytic leukemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iijima, Masahide</creatorcontrib><creatorcontrib>Sekiguchi, Naohiro</creatorcontrib><creatorcontrib>Nagata, Akihisa</creatorcontrib><creatorcontrib>Wagatsuma, Miyuki</creatorcontrib><creatorcontrib>Midorikawa, Kiyoe</creatorcontrib><creatorcontrib>Kurimoto, Miwa</creatorcontrib><creatorcontrib>Noto, Satoshi</creatorcontrib><creatorcontrib>Yamada, Kazuaki</creatorcontrib><creatorcontrib>Takezako, Naoki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iijima, Masahide</au><au>Sekiguchi, Naohiro</au><au>Nagata, Akihisa</au><au>Wagatsuma, Miyuki</au><au>Midorikawa, Kiyoe</au><au>Kurimoto, Miwa</au><au>Noto, Satoshi</au><au>Yamada, Kazuaki</au><au>Takezako, Naoki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gamma Heavy Chain Disease with T-cell Large Granular Lymphocytic Leukemia: A Case Report and Review of the Literature</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>55</volume><issue>4</issue><spage>399</spage><epage>403</epage><pages>399-403</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Gamma heavy chain disease (gHCD) is a rare lymphoproliferative disorder characterized by the production of a truncated immunoglobulin heavy chain. Although some cases of gHCD are concurrent with other lymphoid neoplasms, few have been reported. We herein present the case of a 73-year-old woman with gHCD and T-cell large granular lymphocytic leukemia. A multiparameter flow cytometry analysis revealed neoplastic cells that were positive for CD28, a marker of T-cell activation, the anti-apoptotic antigen of neoplastic plasma cells, CD38 and CD45. The results of this multiparameter flow cytometry analysis may contribute to furthering the understanding of the clinicopathological features of gHCD.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>26875967</pmid><doi>10.2169/internalmedicine.55.5042</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Internal Medicine, 2016, Vol.55(4), pp.399-403 |
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| subjects | Aged Anemia - etiology Anemia - immunology composite lymphoid malignancy Cytogenetic Analysis Fatigue - etiology Fatigue - immunology Female Flow Cytometry gamma heavy chain disease Heavy Chain Disease - complications Heavy Chain Disease - immunology Heavy Chain Disease - pathology Humans Immunoglobulin gamma-Chains - blood Immunoglobulin gamma-Chains - metabolism Immunoglobulin Heavy Chains Leukemia, Large Granular Lymphocytic - complications Leukemia, Large Granular Lymphocytic - immunology Leukemia, Large Granular Lymphocytic - pathology Lymphocytes - metabolism multiparameter flow cytometry analysis T-cell large granular lymphocytic leukemia |
| title | Gamma Heavy Chain Disease with T-cell Large Granular Lymphocytic Leukemia: A Case Report and Review of the Literature |
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