Delayed False Elevation of Circulating Tacrolimus Concentrations after Cord Blood Transplantation in a Patient with Myelodysplastic Syndrome
We herein describe the case of a 60-year-old man with a history of Behçet's disease and myelodysplastic syndrome who received cord blood transplantation (CBT). The patient was given anti-thymocyte globulin conditioning and tacrolimus to prevent graft-versus-host disease. Two months after CBT, h...
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| Veröffentlicht in: | Internal Medicine 2014, Vol.53(22), pp.2635-2638 |
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| container_title | Internal Medicine |
| container_volume | 53 |
| creator | Hayashi, Kiyohito Tasaka, Taizo Hirose, Tadashi Furukawa, Satoko Kohguchi, Katsunori Matsuhashi, Yoshiko Wada, Hideho Tohyama, Kaoru Sugihara, Takashi |
| description | We herein describe the case of a 60-year-old man with a history of Behçet's disease and myelodysplastic syndrome who received cord blood transplantation (CBT). The patient was given anti-thymocyte globulin conditioning and tacrolimus to prevent graft-versus-host disease. Two months after CBT, his blood Tac concentration measured by an antibody-conjugated magnetic immunoassay (ACMIA) was found to have increased >4-fold, even after the Tac treatment was stopped. This false response was caused by the interference of endogenous heterophilic antibodies with ACMIA. Therefore, physicians must be aware of possible false ACMIA results for patients with a history of autoimmune disease and/or treated by xenogeneic antibody therapy. |
| doi_str_mv | 10.2169/internalmedicine.53.2170 |
| format | Article |
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The patient was given anti-thymocyte globulin conditioning and tacrolimus to prevent graft-versus-host disease. Two months after CBT, his blood Tac concentration measured by an antibody-conjugated magnetic immunoassay (ACMIA) was found to have increased >4-fold, even after the Tac treatment was stopped. This false response was caused by the interference of endogenous heterophilic antibodies with ACMIA. Therefore, physicians must be aware of possible false ACMIA results for patients with a history of autoimmune disease and/or treated by xenogeneic antibody therapy.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.53.2170</identifier><identifier>PMID: 25400189</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>antibody-conjugated magnetic immunoassay ; autoimmune diseases ; Behcet Syndrome - epidemiology ; Cord Blood Stem Cell Transplantation ; cord blood transplantation ; Cyclosporine - administration & dosage ; False Positive Reactions ; Graft vs Host Disease - prevention & control ; Humans ; Immunoassay ; Immunosuppressive Agents - administration & dosage ; Male ; Middle Aged ; Myelodysplastic Syndromes - epidemiology ; Myelodysplastic Syndromes - therapy ; tacrolimus ; Tacrolimus - administration & dosage</subject><ispartof>Internal Medicine, 2014, Vol.53(22), pp.2635-2638</ispartof><rights>2014 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c560t-68e6d40c96f7746bb4606adf2b5dfb66b16ad07efc9d4c29ea940ce0116f1f093</citedby><cites>FETCH-LOGICAL-c560t-68e6d40c96f7746bb4606adf2b5dfb66b16ad07efc9d4c29ea940ce0116f1f093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25400189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hayashi, Kiyohito</creatorcontrib><creatorcontrib>Tasaka, Taizo</creatorcontrib><creatorcontrib>Hirose, Tadashi</creatorcontrib><creatorcontrib>Furukawa, Satoko</creatorcontrib><creatorcontrib>Kohguchi, Katsunori</creatorcontrib><creatorcontrib>Matsuhashi, Yoshiko</creatorcontrib><creatorcontrib>Wada, Hideho</creatorcontrib><creatorcontrib>Tohyama, Kaoru</creatorcontrib><creatorcontrib>Sugihara, Takashi</creatorcontrib><title>Delayed False Elevation of Circulating Tacrolimus Concentrations after Cord Blood Transplantation in a Patient with Myelodysplastic Syndrome</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>We herein describe the case of a 60-year-old man with a history of Behçet's disease and myelodysplastic syndrome who received cord blood transplantation (CBT). The patient was given anti-thymocyte globulin conditioning and tacrolimus to prevent graft-versus-host disease. Two months after CBT, his blood Tac concentration measured by an antibody-conjugated magnetic immunoassay (ACMIA) was found to have increased >4-fold, even after the Tac treatment was stopped. This false response was caused by the interference of endogenous heterophilic antibodies with ACMIA. Therefore, physicians must be aware of possible false ACMIA results for patients with a history of autoimmune disease and/or treated by xenogeneic antibody therapy.</description><subject>antibody-conjugated magnetic immunoassay</subject><subject>autoimmune diseases</subject><subject>Behcet Syndrome - epidemiology</subject><subject>Cord Blood Stem Cell Transplantation</subject><subject>cord blood transplantation</subject><subject>Cyclosporine - administration & dosage</subject><subject>False Positive Reactions</subject><subject>Graft vs Host Disease - prevention & control</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myelodysplastic Syndromes - epidemiology</subject><subject>Myelodysplastic Syndromes - therapy</subject><subject>tacrolimus</subject><subject>Tacrolimus - administration & dosage</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAQxy0EokvhFZCPXNLaiePER1hailRUJJZz5Njj1pVjL7YDyjvw0DjssgeExGXsmfnNh-aPEKbkoqZcXFqfIXrpJtBWWQ8XbVMSHXmCNrRhourqpn2KNkTQvqqLOUMvUnokpOk7UT9HZ3XLCKG92KCf78HJBTS-li4BvnLwXWYbPA4Gb21Usyuuv8c7qWJwdpoT3gavwOf4m0tYmrJLCUaN37kQNN5F6dPeSZ8PnazHEn8u_1KEf9j8gD8t4IJeVihlq_CXxesYJniJnpl1jVfH9xx9vb7abW-q27sPH7dvbyvVcpIr3gPXjCjBTdcxPo6MEy61qcdWm5HzkRaPdGCU0EzVAqQoNBBKuaGGiOYcvTn03cfwbYaUh8kmBa7sDGFOA-0Ea0m5ZPd_lDeMiZ40vKD9AS2XSimCGfbRTjIuAyXDKtvwt2xD2wyrbKX09XHKPJbkqfCPTgW4OwCPKct7OAEylvs5-HfnerXHESdSPcg4gG9-AcBuuYY</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Hayashi, Kiyohito</creator><creator>Tasaka, Taizo</creator><creator>Hirose, Tadashi</creator><creator>Furukawa, Satoko</creator><creator>Kohguchi, Katsunori</creator><creator>Matsuhashi, Yoshiko</creator><creator>Wada, Hideho</creator><creator>Tohyama, Kaoru</creator><creator>Sugihara, Takashi</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20140101</creationdate><title>Delayed False Elevation of Circulating Tacrolimus Concentrations after Cord Blood Transplantation in a Patient with Myelodysplastic Syndrome</title><author>Hayashi, Kiyohito ; Tasaka, Taizo ; Hirose, Tadashi ; Furukawa, Satoko ; Kohguchi, Katsunori ; Matsuhashi, Yoshiko ; Wada, Hideho ; Tohyama, Kaoru ; Sugihara, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c560t-68e6d40c96f7746bb4606adf2b5dfb66b16ad07efc9d4c29ea940ce0116f1f093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>antibody-conjugated magnetic immunoassay</topic><topic>autoimmune diseases</topic><topic>Behcet Syndrome - epidemiology</topic><topic>Cord Blood Stem Cell Transplantation</topic><topic>cord blood transplantation</topic><topic>Cyclosporine - administration & dosage</topic><topic>False Positive Reactions</topic><topic>Graft vs Host Disease - prevention & control</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Immunosuppressive Agents - administration & dosage</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myelodysplastic Syndromes - epidemiology</topic><topic>Myelodysplastic Syndromes - therapy</topic><topic>tacrolimus</topic><topic>Tacrolimus - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hayashi, Kiyohito</creatorcontrib><creatorcontrib>Tasaka, Taizo</creatorcontrib><creatorcontrib>Hirose, Tadashi</creatorcontrib><creatorcontrib>Furukawa, Satoko</creatorcontrib><creatorcontrib>Kohguchi, Katsunori</creatorcontrib><creatorcontrib>Matsuhashi, Yoshiko</creatorcontrib><creatorcontrib>Wada, Hideho</creatorcontrib><creatorcontrib>Tohyama, Kaoru</creatorcontrib><creatorcontrib>Sugihara, Takashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hayashi, Kiyohito</au><au>Tasaka, Taizo</au><au>Hirose, Tadashi</au><au>Furukawa, Satoko</au><au>Kohguchi, Katsunori</au><au>Matsuhashi, Yoshiko</au><au>Wada, Hideho</au><au>Tohyama, Kaoru</au><au>Sugihara, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delayed False Elevation of Circulating Tacrolimus Concentrations after Cord Blood Transplantation in a Patient with Myelodysplastic Syndrome</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>53</volume><issue>22</issue><spage>2635</spage><epage>2638</epage><pages>2635-2638</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>We herein describe the case of a 60-year-old man with a history of Behçet's disease and myelodysplastic syndrome who received cord blood transplantation (CBT). The patient was given anti-thymocyte globulin conditioning and tacrolimus to prevent graft-versus-host disease. Two months after CBT, his blood Tac concentration measured by an antibody-conjugated magnetic immunoassay (ACMIA) was found to have increased >4-fold, even after the Tac treatment was stopped. This false response was caused by the interference of endogenous heterophilic antibodies with ACMIA. Therefore, physicians must be aware of possible false ACMIA results for patients with a history of autoimmune disease and/or treated by xenogeneic antibody therapy.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>25400189</pmid><doi>10.2169/internalmedicine.53.2170</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Internal Medicine, 2014, Vol.53(22), pp.2635-2638 |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | antibody-conjugated magnetic immunoassay autoimmune diseases Behcet Syndrome - epidemiology Cord Blood Stem Cell Transplantation cord blood transplantation Cyclosporine - administration & dosage False Positive Reactions Graft vs Host Disease - prevention & control Humans Immunoassay Immunosuppressive Agents - administration & dosage Male Middle Aged Myelodysplastic Syndromes - epidemiology Myelodysplastic Syndromes - therapy tacrolimus Tacrolimus - administration & dosage |
| title | Delayed False Elevation of Circulating Tacrolimus Concentrations after Cord Blood Transplantation in a Patient with Myelodysplastic Syndrome |
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