Alpha-linolenic acid regulates Cox2/VEGF/MAP kinase pathway and decreases the expression of HPV oncoproteins E6/E7 through restoration of p53 and Rb expression in human cervical cancer cell lines

Cervical cancer represents the largest cause of mortality in women worldwide. In our previous report, we have shown how alpha-linolenic acid (ALA), an omega-3 fatty acid, regulated the growth of cervical cancer cells. The present study aimed to explore mechanistic details for the anticancer activity...

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Veröffentlicht in:	Tumor biology 2016-03, Vol.37 (3), p.3295-3305
Hauptverfasser:	Deshpande, Rashmi, Mansara, Prakash, Kaul-Ghanekar, Ruchika
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids alpha-Linolenic Acid - pharmacology Biomedical and Life Sciences Biomedicine Cancer Research Cell Line, Tumor Cell Proliferation - drug effects Cervical cancer Cyclooxygenase 2 - metabolism DNA-Binding Proteins - metabolism Dose-Response Relationship, Drug Female HeLa Cells Host-Pathogen Interactions Human papillomavirus Human papillomavirus 16 - metabolism Human papillomavirus 16 - physiology Human papillomavirus 18 - metabolism Human papillomavirus 18 - physiology Humans Immunoblotting Kinases MAP Kinase Signaling System - drug effects Mitogen-Activated Protein Kinases - metabolism NF-kappa B - metabolism Oncogene Proteins, Viral - metabolism Original Article Papillomavirus E7 Proteins - metabolism Phosphorylation - drug effects Proteins Repressor Proteins - metabolism Retinoblastoma Protein - metabolism Tumor Suppressor Protein p53 - metabolism Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - virology Vascular Endothelial Growth Factor A - metabolism
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