N-glycosylation heterogeneity and the influence on structure, function and pharmacokinetics of monoclonal antibodies and Fc fusion proteins

[Display omitted] Monoclonal antibody and Fc fusion protein drugs are complex heterogeneous mixtures of numerous different protein variants and modifications. N-glycosylation as one of the most complex post-translational modification influences the structural characteristics of the antibodies Fc par...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2016-03, Vol.100, p.94-100
Hauptverfasser:	Higel, Fabian, Seidl, Andreas, Sörgel, Fritz, Friess, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - pharmacokinetics Fusion protein Glyco-engineering Glycosylation Humans Immunoglobulin Fc Fragments - chemistry Immunoglobulin Fc Fragments - metabolism Monoclonal antibody N-glycosylation Pharmacokinetics Polysaccharides - chemistry Polysaccharides - pharmacokinetics
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