Characterization of IgA1 protease as a surface protective antigen of Streptococcus suis serotype 2
IgA1 protease of Streptococcus suis serotype 2 (SS2) has been proven to be relative with virulence and immunogenicity, however, its protective efficacy remained to be evaluated. The present study found evidence that immunization with purified recombinant IgA1 protease (600-1926aa) could induce high...
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| Veröffentlicht in: | Microbes and infection 2016-04, Vol.18 (4), p.285-289 |
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| container_title | Microbes and infection |
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| creator | Fu, Lei Zhao, Jianqing Lin, Lan Zhang, Qiang Xu, Zhongmin Han, Li Xie, Caiyun Zhou, Rui Jin, Meilin Zhang, Anding |
| description | IgA1 protease of Streptococcus suis serotype 2 (SS2) has been proven to be relative with virulence and immunogenicity, however, its protective efficacy remained to be evaluated. The present study found evidence that immunization with purified recombinant IgA1 protease (600-1926aa) could induce high IgG antibody titers and could confer complete protection against a challenge with a lethal dose of SS2 in a mouse model. In addition, our findings confirmed that the IgA1 protease distributes on the surface of SS2. Therefore, the present study identified the virulence-associated protein, IgA1 protease, as a novel surface protective antigen of SS2. |
| doi_str_mv | 10.1016/j.micinf.2015.12.005 |
| format | Article |
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The present study found evidence that immunization with purified recombinant IgA1 protease (600-1926aa) could induce high IgG antibody titers and could confer complete protection against a challenge with a lethal dose of SS2 in a mouse model. In addition, our findings confirmed that the IgA1 protease distributes on the surface of SS2. Therefore, the present study identified the virulence-associated protein, IgA1 protease, as a novel surface protective antigen of SS2.</description><identifier>ISSN: 1286-4579</identifier><identifier>EISSN: 1769-714X</identifier><identifier>DOI: 10.1016/j.micinf.2015.12.005</identifier><identifier>PMID: 26774332</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Animals ; Antibodies, Bacterial - blood ; Antigens, Bacterial - immunology ; Disease Models, Animal ; IgA1 protease ; Membrane Proteins - immunology ; Mice, Inbred BALB C ; Protective antigen ; Serine Endopeptidases - immunology ; Serogroup ; Streptococcal Infections - immunology ; Streptococcal Infections - prevention & control ; Streptococcal Vaccines - administration & dosage ; Streptococcal Vaccines - genetics ; Streptococcal Vaccines - immunology ; Streptococcus suis ; Streptococcus suis - classification ; Streptococcus suis - enzymology ; Streptococcus suis - immunology ; Vaccines, Synthetic - administration & dosage ; Vaccines, Synthetic - genetics ; Vaccines, Synthetic - immunology</subject><ispartof>Microbes and infection, 2016-04, Vol.18 (4), p.285-289</ispartof><rights>2016 Institut Pasteur</rights><rights>Copyright © 2016 Institut Pasteur. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-116fd3fc32b6691da438d728272a69dff8d2938f035525c9161354cd107ea32a3</citedby><cites>FETCH-LOGICAL-c441t-116fd3fc32b6691da438d728272a69dff8d2938f035525c9161354cd107ea32a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.micinf.2015.12.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26774332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Lei</creatorcontrib><creatorcontrib>Zhao, Jianqing</creatorcontrib><creatorcontrib>Lin, Lan</creatorcontrib><creatorcontrib>Zhang, Qiang</creatorcontrib><creatorcontrib>Xu, Zhongmin</creatorcontrib><creatorcontrib>Han, Li</creatorcontrib><creatorcontrib>Xie, Caiyun</creatorcontrib><creatorcontrib>Zhou, Rui</creatorcontrib><creatorcontrib>Jin, Meilin</creatorcontrib><creatorcontrib>Zhang, Anding</creatorcontrib><title>Characterization of IgA1 protease as a surface protective antigen of Streptococcus suis serotype 2</title><title>Microbes and infection</title><addtitle>Microbes Infect</addtitle><description>IgA1 protease of Streptococcus suis serotype 2 (SS2) has been proven to be relative with virulence and immunogenicity, however, its protective efficacy remained to be evaluated. The present study found evidence that immunization with purified recombinant IgA1 protease (600-1926aa) could induce high IgG antibody titers and could confer complete protection against a challenge with a lethal dose of SS2 in a mouse model. In addition, our findings confirmed that the IgA1 protease distributes on the surface of SS2. Therefore, the present study identified the virulence-associated protein, IgA1 protease, as a novel surface protective antigen of SS2.</description><subject>Animals</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antigens, Bacterial - immunology</subject><subject>Disease Models, Animal</subject><subject>IgA1 protease</subject><subject>Membrane Proteins - immunology</subject><subject>Mice, Inbred BALB C</subject><subject>Protective antigen</subject><subject>Serine Endopeptidases - immunology</subject><subject>Serogroup</subject><subject>Streptococcal Infections - immunology</subject><subject>Streptococcal Infections - prevention & control</subject><subject>Streptococcal Vaccines - administration & dosage</subject><subject>Streptococcal Vaccines - genetics</subject><subject>Streptococcal Vaccines - immunology</subject><subject>Streptococcus suis</subject><subject>Streptococcus suis - classification</subject><subject>Streptococcus suis - enzymology</subject><subject>Streptococcus suis - immunology</subject><subject>Vaccines, Synthetic - administration & dosage</subject><subject>Vaccines, Synthetic - genetics</subject><subject>Vaccines, Synthetic - immunology</subject><issn>1286-4579</issn><issn>1769-714X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v3CAQxVHVqPnTfoOq8rEXuwxgMJdK0SptIkXKIanUG2JhSFnt2lvAK6WfPiROemwvgEa_x8y8R8hHoB1QkF823S66OIaOUeg7YB2l_RtyAkrqVoH4-ba-2SBb0St9TE5z3tAKKinekWMmlRKcsxOyXv2yybqCKf6xJU5jM4Xm6v4cmn2aCtqMjc2NbfKcgnW4VF2Jh1ofS7zHZ8FtSbgvk5ucm3NlYz2wkg97bNh7chTsNuOHl_uM_Ph2cbe6bK9vvl-tzq9bJwSUFkAGz4PjbC2lBm8FH7xiA1PMSu1DGDzTfAiU9z3rnQYJvBfOA1VoObP8jHxe_q0z_p4xF7OL2eF2a0ec5mxAaSG0hrr5_1GlBzUMPa-oWFCXppwTBrNPcWfTgwFqnoIwG7MEYZ6CMMBMDaLKPr10mNc79H9Fr85X4OsCYLXkEDGZ7CKODn1M1WDjp_jvDo8c05sA</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Fu, Lei</creator><creator>Zhao, Jianqing</creator><creator>Lin, Lan</creator><creator>Zhang, Qiang</creator><creator>Xu, Zhongmin</creator><creator>Han, Li</creator><creator>Xie, Caiyun</creator><creator>Zhou, Rui</creator><creator>Jin, Meilin</creator><creator>Zhang, Anding</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>201604</creationdate><title>Characterization of IgA1 protease as a surface protective antigen of Streptococcus suis serotype 2</title><author>Fu, Lei ; Zhao, Jianqing ; Lin, Lan ; Zhang, Qiang ; Xu, Zhongmin ; Han, Li ; Xie, Caiyun ; Zhou, Rui ; Jin, Meilin ; Zhang, Anding</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-116fd3fc32b6691da438d728272a69dff8d2938f035525c9161354cd107ea32a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antigens, Bacterial - immunology</topic><topic>Disease Models, Animal</topic><topic>IgA1 protease</topic><topic>Membrane Proteins - immunology</topic><topic>Mice, Inbred BALB C</topic><topic>Protective antigen</topic><topic>Serine Endopeptidases - immunology</topic><topic>Serogroup</topic><topic>Streptococcal Infections - immunology</topic><topic>Streptococcal Infections - prevention & control</topic><topic>Streptococcal Vaccines - administration & dosage</topic><topic>Streptococcal Vaccines - genetics</topic><topic>Streptococcal Vaccines - immunology</topic><topic>Streptococcus suis</topic><topic>Streptococcus suis - classification</topic><topic>Streptococcus suis - enzymology</topic><topic>Streptococcus suis - immunology</topic><topic>Vaccines, Synthetic - administration & dosage</topic><topic>Vaccines, Synthetic - genetics</topic><topic>Vaccines, Synthetic - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fu, Lei</creatorcontrib><creatorcontrib>Zhao, Jianqing</creatorcontrib><creatorcontrib>Lin, Lan</creatorcontrib><creatorcontrib>Zhang, Qiang</creatorcontrib><creatorcontrib>Xu, Zhongmin</creatorcontrib><creatorcontrib>Han, Li</creatorcontrib><creatorcontrib>Xie, Caiyun</creatorcontrib><creatorcontrib>Zhou, Rui</creatorcontrib><creatorcontrib>Jin, Meilin</creatorcontrib><creatorcontrib>Zhang, Anding</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Microbes and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Lei</au><au>Zhao, Jianqing</au><au>Lin, Lan</au><au>Zhang, Qiang</au><au>Xu, Zhongmin</au><au>Han, Li</au><au>Xie, Caiyun</au><au>Zhou, Rui</au><au>Jin, Meilin</au><au>Zhang, Anding</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of IgA1 protease as a surface protective antigen of Streptococcus suis serotype 2</atitle><jtitle>Microbes and infection</jtitle><addtitle>Microbes Infect</addtitle><date>2016-04</date><risdate>2016</risdate><volume>18</volume><issue>4</issue><spage>285</spage><epage>289</epage><pages>285-289</pages><issn>1286-4579</issn><eissn>1769-714X</eissn><abstract>IgA1 protease of Streptococcus suis serotype 2 (SS2) has been proven to be relative with virulence and immunogenicity, however, its protective efficacy remained to be evaluated. The present study found evidence that immunization with purified recombinant IgA1 protease (600-1926aa) could induce high IgG antibody titers and could confer complete protection against a challenge with a lethal dose of SS2 in a mouse model. In addition, our findings confirmed that the IgA1 protease distributes on the surface of SS2. Therefore, the present study identified the virulence-associated protein, IgA1 protease, as a novel surface protective antigen of SS2.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>26774332</pmid><doi>10.1016/j.micinf.2015.12.005</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antibodies, Bacterial - blood Antigens, Bacterial - immunology Disease Models, Animal IgA1 protease Membrane Proteins - immunology Mice, Inbred BALB C Protective antigen Serine Endopeptidases - immunology Serogroup Streptococcal Infections - immunology Streptococcal Infections - prevention & control Streptococcal Vaccines - administration & dosage Streptococcal Vaccines - genetics Streptococcal Vaccines - immunology Streptococcus suis Streptococcus suis - classification Streptococcus suis - enzymology Streptococcus suis - immunology Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology |
| title | Characterization of IgA1 protease as a surface protective antigen of Streptococcus suis serotype 2 |
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