HLA-G expression and regulation during Pseudomonas aeruginosa infection in cystic fibrosis patients
Deregulated immune response fails to control biofilm-forming bacteria, as Pseudomonas aeruginosa, in the lungs of cystic fibrosis (CF) patients. HLA-G is an immune-modulatory molecule involved in respiratory diseases and infections. HLA-G mRNA and protein were analyzed in plasma and exhaled breath c...
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| Veröffentlicht in: | Future microbiology 2016-01, Vol.11 (3), p.363-373 |
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| creator | Rizzo, Roberta Bergamini, Gabriella Bortolotti, Daria Leal, Teresinha D'Orazio, Ciro Pintani, Emily Melchiorri, Loredana Zavatti, Eleonora Assael, Baroukh M Sorio, Claudio Melotti, Paola |
| description | Deregulated immune response fails to control biofilm-forming bacteria, as Pseudomonas aeruginosa, in the lungs of cystic fibrosis (CF) patients. HLA-G is an immune-modulatory molecule involved in respiratory diseases and infections.
HLA-G mRNA and protein were analyzed in plasma and exhaled breath condensate from CF patients undergoing intravenous antibiotic treatment, CF cell line and murine model.
Therapy normalizes HLA-G plasmatic in CF patients suggesting a systemic anti-inflammatory role while in CF airway system, higher expression of HLA-G is associated with P. aeruginosa infection. CF cell line and murine model expressed higher HLA-G molecules in the presence of P. aeruginosa.
Plasmatic and lung HLA-G expression suggest a role in reducing systemic inflammation and supporting P. aeruginosa infection. |
| doi_str_mv | 10.2217/fmb.15.143 |
| format | Article |
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HLA-G mRNA and protein were analyzed in plasma and exhaled breath condensate from CF patients undergoing intravenous antibiotic treatment, CF cell line and murine model.
Therapy normalizes HLA-G plasmatic in CF patients suggesting a systemic anti-inflammatory role while in CF airway system, higher expression of HLA-G is associated with P. aeruginosa infection. CF cell line and murine model expressed higher HLA-G molecules in the presence of P. aeruginosa.
Plasmatic and lung HLA-G expression suggest a role in reducing systemic inflammation and supporting P. aeruginosa infection.</description><identifier>ISSN: 1746-0913</identifier><identifier>EISSN: 1746-0921</identifier><identifier>DOI: 10.2217/fmb.15.143</identifier><identifier>PMID: 26934639</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Administration, Intravenous ; Animal models ; Animals ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Asthma ; Bacterial infections ; Biofilms ; Bronchi - immunology ; Bronchoalveolar Lavage Fluid - immunology ; Cell Line ; Cystic fibrosis ; Cystic Fibrosis - complications ; Cystic Fibrosis - genetics ; Cystic Fibrosis - microbiology ; Disease Models, Animal ; Genotype & phenotype ; Histocompatibility antigen HLA ; Histocompatibility Antigens Class I - genetics ; HLA-G Antigens - analysis ; HLA-G Antigens - blood ; HLA-G Antigens - genetics ; Host-Pathogen Interactions ; Humans ; Immune response ; Immunomodulation ; Infections ; Inflammation ; Intravenous administration ; Lung - immunology ; Mice ; mRNA ; Plasma ; Polymorphism ; Prospective Studies ; Proteins ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - immunology ; Pseudomonas Infections - drug therapy ; Pseudomonas Infections - genetics ; Pseudomonas Infections - immunology ; Respiratory diseases ; Respiratory Mucosa - immunology ; Standard deviation ; Staphylococcus infections ; Viral infections</subject><ispartof>Future microbiology, 2016-01, Vol.11 (3), p.363-373</ispartof><rights>Copyright Future Medicine Ltd Mar 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-2aa352cb44d228ec6785f5637889e2585cff1ed57a331703dc3a75411d8ff96a3</citedby><cites>FETCH-LOGICAL-c348t-2aa352cb44d228ec6785f5637889e2585cff1ed57a331703dc3a75411d8ff96a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26934639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rizzo, Roberta</creatorcontrib><creatorcontrib>Bergamini, Gabriella</creatorcontrib><creatorcontrib>Bortolotti, Daria</creatorcontrib><creatorcontrib>Leal, Teresinha</creatorcontrib><creatorcontrib>D'Orazio, Ciro</creatorcontrib><creatorcontrib>Pintani, Emily</creatorcontrib><creatorcontrib>Melchiorri, Loredana</creatorcontrib><creatorcontrib>Zavatti, Eleonora</creatorcontrib><creatorcontrib>Assael, Baroukh M</creatorcontrib><creatorcontrib>Sorio, Claudio</creatorcontrib><creatorcontrib>Melotti, Paola</creatorcontrib><title>HLA-G expression and regulation during Pseudomonas aeruginosa infection in cystic fibrosis patients</title><title>Future microbiology</title><addtitle>Future Microbiol</addtitle><description>Deregulated immune response fails to control biofilm-forming bacteria, as Pseudomonas aeruginosa, in the lungs of cystic fibrosis (CF) patients. HLA-G is an immune-modulatory molecule involved in respiratory diseases and infections.
HLA-G mRNA and protein were analyzed in plasma and exhaled breath condensate from CF patients undergoing intravenous antibiotic treatment, CF cell line and murine model.
Therapy normalizes HLA-G plasmatic in CF patients suggesting a systemic anti-inflammatory role while in CF airway system, higher expression of HLA-G is associated with P. aeruginosa infection. CF cell line and murine model expressed higher HLA-G molecules in the presence of P. aeruginosa.
Plasmatic and lung HLA-G expression suggest a role in reducing systemic inflammation and supporting P. aeruginosa infection.</description><subject>Administration, Intravenous</subject><subject>Animal models</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Asthma</subject><subject>Bacterial infections</subject><subject>Biofilms</subject><subject>Bronchi - immunology</subject><subject>Bronchoalveolar Lavage Fluid - immunology</subject><subject>Cell Line</subject><subject>Cystic fibrosis</subject><subject>Cystic Fibrosis - complications</subject><subject>Cystic Fibrosis - genetics</subject><subject>Cystic Fibrosis - microbiology</subject><subject>Disease Models, Animal</subject><subject>Genotype & phenotype</subject><subject>Histocompatibility antigen HLA</subject><subject>Histocompatibility Antigens Class I - genetics</subject><subject>HLA-G Antigens - 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Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Future microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rizzo, Roberta</au><au>Bergamini, Gabriella</au><au>Bortolotti, Daria</au><au>Leal, Teresinha</au><au>D'Orazio, Ciro</au><au>Pintani, Emily</au><au>Melchiorri, Loredana</au><au>Zavatti, Eleonora</au><au>Assael, Baroukh M</au><au>Sorio, Claudio</au><au>Melotti, Paola</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA-G expression and regulation during Pseudomonas aeruginosa infection in cystic fibrosis patients</atitle><jtitle>Future microbiology</jtitle><addtitle>Future Microbiol</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>11</volume><issue>3</issue><spage>363</spage><epage>373</epage><pages>363-373</pages><issn>1746-0913</issn><eissn>1746-0921</eissn><abstract>Deregulated immune response fails to control biofilm-forming bacteria, as Pseudomonas aeruginosa, in the lungs of cystic fibrosis (CF) patients. HLA-G is an immune-modulatory molecule involved in respiratory diseases and infections.
HLA-G mRNA and protein were analyzed in plasma and exhaled breath condensate from CF patients undergoing intravenous antibiotic treatment, CF cell line and murine model.
Therapy normalizes HLA-G plasmatic in CF patients suggesting a systemic anti-inflammatory role while in CF airway system, higher expression of HLA-G is associated with P. aeruginosa infection. CF cell line and murine model expressed higher HLA-G molecules in the presence of P. aeruginosa.
Plasmatic and lung HLA-G expression suggest a role in reducing systemic inflammation and supporting P. aeruginosa infection.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>26934639</pmid><doi>10.2217/fmb.15.143</doi><tpages>11</tpages></addata></record> |
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| subjects | Administration, Intravenous Animal models Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Antibiotics Asthma Bacterial infections Biofilms Bronchi - immunology Bronchoalveolar Lavage Fluid - immunology Cell Line Cystic fibrosis Cystic Fibrosis - complications Cystic Fibrosis - genetics Cystic Fibrosis - microbiology Disease Models, Animal Genotype & phenotype Histocompatibility antigen HLA Histocompatibility Antigens Class I - genetics HLA-G Antigens - analysis HLA-G Antigens - blood HLA-G Antigens - genetics Host-Pathogen Interactions Humans Immune response Immunomodulation Infections Inflammation Intravenous administration Lung - immunology Mice mRNA Plasma Polymorphism Prospective Studies Proteins Pseudomonas aeruginosa Pseudomonas aeruginosa - immunology Pseudomonas Infections - drug therapy Pseudomonas Infections - genetics Pseudomonas Infections - immunology Respiratory diseases Respiratory Mucosa - immunology Standard deviation Staphylococcus infections Viral infections |
| title | HLA-G expression and regulation during Pseudomonas aeruginosa infection in cystic fibrosis patients |
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