Prevention of vascular smooth muscle cell proliferation and injury-induced neointimal hyperplasia by CREB-mediated p21 induction: An insight from a plant polyphenol

[Display omitted] Cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/cAMP response element (CRE)-binding protein (CREB) signaling cascade negatively regulates platelet-derived growth factor BB (PDGF-BB)-induced smooth muscle cell (SMC) proliferation, which is a critical event in the initia...

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Veröffentlicht in:	Biochemical pharmacology 2016-03, Vol.103, p.40-52
Hauptverfasser:	Sun, Lan, Zhao, Rui, Zhang, Li, Zhang, Weiku, He, GuoRong, Yang, Shengqian, Song, Junke, Du, Guanhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - pharmacology Animals cAMP response element-binding protein (CREB) Carotid Artery Injuries - pathology Carotid Artery Injuries - prevention & control Cell Cycle Checkpoints - drug effects Cell proliferation Cell Proliferation - drug effects Cells, Cultured Cyclic AMP - metabolism Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis Humans Hyperplasia Male Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - pathology Polyphenols Polyphenols - pharmacology Rats, Sprague-Dawley Salvia Signal Transduction Tunica Intima - drug effects Tunica Intima - pathology Vascular remodeling
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