Occurrence and significance of tumor‐associated neutrophils in patients with colorectal cancer

Inflammatory cells are an essential component of the tumor microenvironment. Neutrophils have emerged as important players in the orchestration and effector phase of innate and adaptive immunity. The significance of tumor‐associated neutrophils (TAN) in colorectal cancer (CRC) has been the subject o...

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Veröffentlicht in:	International journal of cancer 2016-07, Vol.139 (2), p.446-456
Hauptverfasser:	Galdiero, Maria Rosaria, Bianchi, Paolo, Grizzi, Fabio, Di Caro, Giuseppe, Basso, Gianluca, Ponzetta, Andrea, Bonavita, Eduardo, Barbagallo, Marialuisa, Tartari, Silvia, Polentarutti, Nadia, Malesci, Alberto, Marone, Gianni, Roncalli, Massimo, Laghi, Luigi, Garlanda, Cecilia, Mantovani, Alberto, Jaillon, Sébastien
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Adaptive immunity Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers Cancer Chemotherapy Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Density Disease Progression Female Humans Immunohistochemistry Inflammation innate immunity Leukocytes (neutrophilic) Macrophages Male Medical research Metastases Microsatellite Repeats Middle Aged Multivariate analysis Neoplasm Staging Neutrophil Infiltration Neutrophils Neutrophils - metabolism Neutrophils - pathology Peroxidase predictive markers Prognosis Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism Survival Analysis Tissues Tumors
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