Quadruple Cancers of Non-producing Multiple Myeloma, Cholangiocellular Carcinoma, and Two Different Thyroid Cancers
We report the case of a 72-year-old man who presented with non-producing multiple myeloma (MM) with three additional concomitant solid tumors that were identified by postmortem autopsy. The disease was refractory to anti-MM therapy including bortezomib and lenalidomide, and he finally died of bacter...
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| Veröffentlicht in: | Internal Medicine 2016, Vol.55(9), pp.1183-1186 |
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| creator | Mizutani, Shinsuke Kuroda, Junya Sasaki, Nana Kiyota, Miki Tatekawa, Shotaro Tsukamoto, Taku Maegawa, Saori Chinen, Yoshiaki Shimura, Yuji Nagoshi, Hisao Kobayashi, Tsutomu Horiike, Shigeo Tando, So Fushiki, Shinji Taniwaki, Masafumi |
| description | We report the case of a 72-year-old man who presented with non-producing multiple myeloma (MM) with three additional concomitant solid tumors that were identified by postmortem autopsy. The disease was refractory to anti-MM therapy including bortezomib and lenalidomide, and he finally died of bacterial pneumonia with diffuse alveolar damage 8 months after the diagnosis. An autopsy revealed that he was also affected by three other solid cancers, cholangiocellular carcinoma, medullary thyroid cancer and papillary thyroid cancer that were clinically asymptomatic and remained undiagnosed before death. A review of the literature suggests that primary quadruple cancers including MM are extremely rare. |
| doi_str_mv | 10.2169/internalmedicine.55.5319 |
| format | Article |
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The disease was refractory to anti-MM therapy including bortezomib and lenalidomide, and he finally died of bacterial pneumonia with diffuse alveolar damage 8 months after the diagnosis. An autopsy revealed that he was also affected by three other solid cancers, cholangiocellular carcinoma, medullary thyroid cancer and papillary thyroid cancer that were clinically asymptomatic and remained undiagnosed before death. A review of the literature suggests that primary quadruple cancers including MM are extremely rare.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.55.5319</identifier><identifier>PMID: 27150876</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Aged ; autopsy ; Bile Duct Neoplasms - complications ; Bortezomib - therapeutic use ; Carcinoma - complications ; Carcinoma, Neuroendocrine - complications ; Carcinoma, Papillary ; Cholangiocarcinoma - complications ; Humans ; Male ; Multiple Myeloma - complications ; Multiple Myeloma - drug therapy ; non-producing multiple myeloma ; quadruple cancer ; Thalidomide - analogs & derivatives ; Thalidomide - therapeutic use ; Thyroid Neoplasms - complications ; Thyroid Neoplasms - pathology</subject><ispartof>Internal Medicine, 2016, Vol.55(9), pp.1183-1186</ispartof><rights>2016 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c616t-29147a2340e5f6bb258f58f1292e47d1e72f60f1311adc601673dd60f513b0de3</citedby><cites>FETCH-LOGICAL-c616t-29147a2340e5f6bb258f58f1292e47d1e72f60f1311adc601673dd60f513b0de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27150876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mizutani, Shinsuke</creatorcontrib><creatorcontrib>Kuroda, Junya</creatorcontrib><creatorcontrib>Sasaki, Nana</creatorcontrib><creatorcontrib>Kiyota, Miki</creatorcontrib><creatorcontrib>Tatekawa, Shotaro</creatorcontrib><creatorcontrib>Tsukamoto, Taku</creatorcontrib><creatorcontrib>Maegawa, Saori</creatorcontrib><creatorcontrib>Chinen, Yoshiaki</creatorcontrib><creatorcontrib>Shimura, Yuji</creatorcontrib><creatorcontrib>Nagoshi, Hisao</creatorcontrib><creatorcontrib>Kobayashi, Tsutomu</creatorcontrib><creatorcontrib>Horiike, Shigeo</creatorcontrib><creatorcontrib>Tando, So</creatorcontrib><creatorcontrib>Fushiki, Shinji</creatorcontrib><creatorcontrib>Taniwaki, Masafumi</creatorcontrib><title>Quadruple Cancers of Non-producing Multiple Myeloma, Cholangiocellular Carcinoma, and Two Different Thyroid Cancers</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>We report the case of a 72-year-old man who presented with non-producing multiple myeloma (MM) with three additional concomitant solid tumors that were identified by postmortem autopsy. The disease was refractory to anti-MM therapy including bortezomib and lenalidomide, and he finally died of bacterial pneumonia with diffuse alveolar damage 8 months after the diagnosis. An autopsy revealed that he was also affected by three other solid cancers, cholangiocellular carcinoma, medullary thyroid cancer and papillary thyroid cancer that were clinically asymptomatic and remained undiagnosed before death. A review of the literature suggests that primary quadruple cancers including MM are extremely rare.</description><subject>Aged</subject><subject>autopsy</subject><subject>Bile Duct Neoplasms - complications</subject><subject>Bortezomib - therapeutic use</subject><subject>Carcinoma - complications</subject><subject>Carcinoma, Neuroendocrine - complications</subject><subject>Carcinoma, Papillary</subject><subject>Cholangiocarcinoma - complications</subject><subject>Humans</subject><subject>Male</subject><subject>Multiple Myeloma - complications</subject><subject>Multiple Myeloma - drug therapy</subject><subject>non-producing multiple myeloma</subject><subject>quadruple cancer</subject><subject>Thalidomide - analogs & derivatives</subject><subject>Thalidomide - therapeutic use</subject><subject>Thyroid Neoplasms - complications</subject><subject>Thyroid Neoplasms - pathology</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtvGyEUhVHVqnHS_oWKZRcdl8cAw7JyH6mUpKrkrhEe7thEGFyYUeR_XyZOvKi6qIRAuve751x0EMKULBmV-qOPI-Rowx6c732EpRBLwal-gRaUt7pRjIuXaEE07RpWrwt0Wco9IbxTmr1GF0xRQTolF6j8nKzL0yEAXtnYQy44DfguxeaQk5uq-BbfTmH0M3F7hJD29gNe7VKwcetTDyFMweY6nCv72LTR4fVDwp_9MECGOOL17piTd88Ob9CrwYYCb5_eK_Tr65f16rq5-fHt--rTTdNLKsd58VZZxlsCYpCbDRPdUA9lmkGrHAXFBkkGyim1rpeESsWdqxVB-YY44Ffo_Um3fuX3BGU0e1_mjW2ENBVDlW5bLSTV_4F2qu2I5DPandA-p1IyDOaQ_d7mo6HEzOmYv9MxQpg5nTr67sll2tTmefA5jgrcnYD7MtotnAGbR98H-KeyfpQ_OZzBfmezgcj_ALPHriE</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Mizutani, Shinsuke</creator><creator>Kuroda, Junya</creator><creator>Sasaki, Nana</creator><creator>Kiyota, Miki</creator><creator>Tatekawa, Shotaro</creator><creator>Tsukamoto, Taku</creator><creator>Maegawa, Saori</creator><creator>Chinen, Yoshiaki</creator><creator>Shimura, Yuji</creator><creator>Nagoshi, Hisao</creator><creator>Kobayashi, Tsutomu</creator><creator>Horiike, Shigeo</creator><creator>Tando, So</creator><creator>Fushiki, Shinji</creator><creator>Taniwaki, Masafumi</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20160101</creationdate><title>Quadruple Cancers of Non-producing Multiple Myeloma, Cholangiocellular Carcinoma, and Two Different Thyroid Cancers</title><author>Mizutani, Shinsuke ; 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| subjects | Aged autopsy Bile Duct Neoplasms - complications Bortezomib - therapeutic use Carcinoma - complications Carcinoma, Neuroendocrine - complications Carcinoma, Papillary Cholangiocarcinoma - complications Humans Male Multiple Myeloma - complications Multiple Myeloma - drug therapy non-producing multiple myeloma quadruple cancer Thalidomide - analogs & derivatives Thalidomide - therapeutic use Thyroid Neoplasms - complications Thyroid Neoplasms - pathology |
| title | Quadruple Cancers of Non-producing Multiple Myeloma, Cholangiocellular Carcinoma, and Two Different Thyroid Cancers |
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