Structural Insights into the HWE Histidine Kinase Family: The Brucella Blue Light-Activated Histidine Kinase Domain

In response to light, as part of a two-component system, the Brucella blue light-activated histidine kinase (LOV-HK) increases its autophosphorylation, modulating the virulence of this microorganism. The Brucella histidine kinase (HK) domain belongs to the HWE family, for which there is no structura...

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Veröffentlicht in:	Journal of molecular biology 2016-03, Vol.428 (6), p.1165-1179
Hauptverfasser:	Rinaldi, Jimena, Arrar, Mehrnoosh, Sycz, Gabriela, Cerutti, María Laura, Berguer, Paula M., Paris, Gastón, Estrín, Darío Ariel, Martí, Marcelo Adrián, Klinke, Sebastián, Goldbaum, Fernando Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	autophosphorylation mechanism Brucella Brucella - enzymology Crystallography, X-Ray DNA Mutational Analysis Histidine Kinase Molecular Dynamics Simulation molecular dynamics simulations Phosphorylation Protein Conformation Protein Kinases - chemistry Protein Kinases - genetics Protein Kinases - metabolism Protein Multimerization Protein Processing, Post-Translational Proteobacteria signal transduction two-component system X-ray crystallography
Online-Zugang:	Volltext
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