Mechanism of metformin action in MCF-7 and MDA-MB-231 human breast cancer cells involves oxidative stress generation, DNA damage, and transforming growth factor beta 1 induction

The participation of oxidative stress in the mechanism of metformin action in breast cancer remains unclear. We investigated the effects of clinical (6 and 30 mu M) and experimental concentrations of metformin (1000 and 5000 mu M) in MCF-7 and in MDA-MB-231 cells, verifying cytotoxicity, oxidative s...

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Veröffentlicht in:	Tumor biology 2016-04, Vol.37 (4), p.5337-5346
Hauptverfasser:	Marinello, Poliana Camila, Silva, Thamara Nishida Xavier, Panis, Carolina, Neves, Amanda Fouto, Machado, Kaliana Larissa, Borges, Fernando Henrique, Guarnier, Flavia Alessandra, Bernardes, Sara Santos, de-Freitas-Junior, Julio Cesar Madureira, Morgado-Diaz, Jose Andres, Luiz, Rodrigo Cabral, Cecchini, Rubens, Cecchini, Alessandra Lourenco
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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