Malaria sporozoite protein expression enhances baculovirus-mediated gene transfer to hepatocytes

Background Baculovirus vector (BV) is able to transduce foreign genes into mammalian cells efficiently and safely by incorporating a mammalian promoter. In the present study, we tailored the surface proteins expressed by malaria sporozoites to enhance hepatocyte transduction. Sporozoites infect hepa...

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Veröffentlicht in:	The journal of gene medicine 2016-04, Vol.18 (4-6), p.75-85
Hauptverfasser:	Tamura, Takahiko, Kawabata, Chiaki, Matsushita, Shunsuke, Sakaguchi, Miako, Yoshida, Shigeto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Baculoviridae - genetics baculovirus vectors Cell Line, Tumor Cells, Cultured circumsporozoite protein Gene therapy gene transduction Gene Transfer Techniques HeLa Cells Hep G2 Cells Heparan Sulfate Proteoglycans - metabolism hepatocytes Hepatocytes - metabolism Hepatocytes - parasitology Humans Malaria, Falciparum - parasitology Plasmodium falciparum - metabolism Plasmodium falciparum - physiology Protein Binding Protozoan Proteins - genetics Protozoan Proteins - metabolism Sf9 Cells Spodoptera thrombospondin-related anonymous protein
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