Increased effects of MPDAX, a novel xanthine derivative, on antitumor activity of doxorubicin

To clarify the effect of 1-methyl-3-propyl-7- N, N-dimethylpropylamide-xanthine (MPDAX) on doxorubicin (DOX) transport, we examined the efficacy of MPDAX as an amplifier of the antitumor activity of DOX in mice bearing tumors with different properties as to DOX transport across cell membranes. MPDAX...

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Veröffentlicht in:	Toxicology letters 2004-05, Vol.150 (3), p.341-349
Hauptverfasser:	Sadzuka, Yasuyuki, Sugiyama, Tomomi, Suzuki, Hirokazu, Sawanishi, Hiroyuki, Miyamoto, Ken-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Biological and medical sciences Biological Transport - drug effects Cell Line, Tumor Doxorubicin Doxorubicin - pharmacokinetics Doxorubicin - therapeutic use Drug Synergism General aspects Male Medical sciences Mice Mice, Inbred Strains MPDAX Neoplasm Transplantation Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Permeability Pharmacology. Drug treatments Resistance Thymidine - metabolism Tissue Distribution - drug effects Uridine - metabolism Xanthine derivative Xanthines - pharmacology
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