Alteration of the ATM gene occurs in gastric cancer cell lines and primary tumors associated with cellular response to DNA damage

Ataxia telangiectasia mutated (ATM) is the gene mutated in the genetic disorder ataxia telangiectasia (AT), the symptoms of which include sensitivity to radiation and an increased risk of cancer. ATM is a kinase involved in activating the appropriate damage-response pathway, leading to either cell-c...

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Veröffentlicht in:	Mutation research 2004-01, Vol.557 (1), p.41-51
Hauptverfasser:	Zhang, Lian, Jia, Guang, Li, Wen-Mei, Guo, Rui-Fang, Cui, Jian-Tao, Yang, Lin, Lu, You-Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Apoptosis Ataxia Telangiectasia Mutated Proteins ATM gene Biological and medical sciences Cell cycle Cell Cycle Proteins Cell Line, Tumor Cell physiology DNA Damage DNA-Binding Proteins Fundamental and applied biological sciences. Psychology Gastric cancer Genetics of eukaryotes. Biological and molecular evolution Humans Ionizing radiation Medical sciences Molecular and cellular biology Mutation p53 Point Mutation Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - physiology Radiation Tolerance Stomach Neoplasms - etiology Stomach Neoplasms - genetics Toxicology Tumor Suppressor Protein p53 - physiology Tumor Suppressor Proteins
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