Cissus quadrangularis prevented the ovariectomy induced oxidative stress in the femur of adult albino rats
Abstract The increasing evidence suggesting the role of free radicals in bone resorption and bone loss prompted us to explore whether the consumption of antioxidant rich medicinal plant C. quadrangularis modifies antioxidant status in ovariectomized rats. Methods Twenty four female adult rats, 90 da...
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| Veröffentlicht in: | Biomedicine & pharmacotherapy 2016-07, Vol.81, p.416-423 |
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| creator | Muthusami, Sridhar Gopalakrishnan, Vasudevan Stanley, Jone A Krishnamoorthy, Senthilkumar Ilangovan, Ramachandran Gopalakrishnan, Velliyur K Srinivasan, Narasimhan |
| description | Abstract The increasing evidence suggesting the role of free radicals in bone resorption and bone loss prompted us to explore whether the consumption of antioxidant rich medicinal plant C. quadrangularis modifies antioxidant status in ovariectomized rats. Methods Twenty four female adult rats, 90 days old showing regular estrous cycles were used for the present study. The animals were divided into two groups. The Group-1 rats (n = 6) were sham operated and Group-II rats were bilaterally ovariectomized (n = 18) and treated with C. quadrangularis for sixty days (100 mg/ kg body weight and 250 mg/kg body weight). After sixty days, the rats were killed, femora were dissected out, minced and homogenized in Tris-HCl buffer (pH 7.4) and the supernatant was collected and used for biochemical assays. Results Ovariectomy registered a decrease (p |
| doi_str_mv | 10.1016/j.biopha.2016.04.021 |
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Methods Twenty four female adult rats, 90 days old showing regular estrous cycles were used for the present study. The animals were divided into two groups. The Group-1 rats (n = 6) were sham operated and Group-II rats were bilaterally ovariectomized (n = 18) and treated with C. quadrangularis for sixty days (100 mg/ kg body weight and 250 mg/kg body weight). After sixty days, the rats were killed, femora were dissected out, minced and homogenized in Tris-HCl buffer (pH 7.4) and the supernatant was collected and used for biochemical assays. Results Ovariectomy registered a decrease (p<0.05) in the activities of SOD, GPx, GST, ALP, collagen content and increased (p<0.05) the activities of TRAP and lipid peroxidation. Simultaneous administration of C. quadrangularis maintained the enzyme activities in ovariectomized rats. Conclusion C. quadrangularis , a natural herb may be used to treat the estrogen deficiency/menopause onset and ovariectomy induced oxidative stress.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2016.04.021</identifier><identifier>PMID: 27261621</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Aging ; Alkaline Phosphatase - metabolism ; Animals ; Bone loss ; C. quadrangularis ; Cissus - chemistry ; Collagen - metabolism ; Female ; Femur - drug effects ; Femur - enzymology ; Femur - pathology ; Glutathione Peroxidase - metabolism ; Glutathione Transferase - metabolism ; Hydrogen Peroxide - metabolism ; Internal Medicine ; Lipid Peroxidation - drug effects ; Medical Education ; Ovariectomy ; Ovariectomy - adverse effects ; Oxidative stress ; Oxidative Stress - drug effects ; Plant Extracts - pharmacology ; Rats, Wistar ; Superoxide Dismutase - metabolism ; Tartrate-Resistant Acid Phosphatase - metabolism</subject><ispartof>Biomedicine & pharmacotherapy, 2016-07, Vol.81, p.416-423</ispartof><rights>Elsevier Masson SAS</rights><rights>2016 Elsevier Masson SAS</rights><rights>Copyright © 2016 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-204bb873cb5c157510b2d39e4f67d94a8812e3b2472fd993f98015f4c79d503</citedby><cites>FETCH-LOGICAL-c417t-204bb873cb5c157510b2d39e4f67d94a8812e3b2472fd993f98015f4c79d503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biopha.2016.04.021$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27261621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muthusami, Sridhar</creatorcontrib><creatorcontrib>Gopalakrishnan, Vasudevan</creatorcontrib><creatorcontrib>Stanley, Jone A</creatorcontrib><creatorcontrib>Krishnamoorthy, Senthilkumar</creatorcontrib><creatorcontrib>Ilangovan, Ramachandran</creatorcontrib><creatorcontrib>Gopalakrishnan, Velliyur K</creatorcontrib><creatorcontrib>Srinivasan, Narasimhan</creatorcontrib><title>Cissus quadrangularis prevented the ovariectomy induced oxidative stress in the femur of adult albino rats</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>Abstract The increasing evidence suggesting the role of free radicals in bone resorption and bone loss prompted us to explore whether the consumption of antioxidant rich medicinal plant C. quadrangularis modifies antioxidant status in ovariectomized rats. Methods Twenty four female adult rats, 90 days old showing regular estrous cycles were used for the present study. The animals were divided into two groups. The Group-1 rats (n = 6) were sham operated and Group-II rats were bilaterally ovariectomized (n = 18) and treated with C. quadrangularis for sixty days (100 mg/ kg body weight and 250 mg/kg body weight). After sixty days, the rats were killed, femora were dissected out, minced and homogenized in Tris-HCl buffer (pH 7.4) and the supernatant was collected and used for biochemical assays. Results Ovariectomy registered a decrease (p<0.05) in the activities of SOD, GPx, GST, ALP, collagen content and increased (p<0.05) the activities of TRAP and lipid peroxidation. Simultaneous administration of C. quadrangularis maintained the enzyme activities in ovariectomized rats. Conclusion C. quadrangularis , a natural herb may be used to treat the estrogen deficiency/menopause onset and ovariectomy induced oxidative stress.</description><subject>Aging</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>Animals</subject><subject>Bone loss</subject><subject>C. quadrangularis</subject><subject>Cissus - chemistry</subject><subject>Collagen - metabolism</subject><subject>Female</subject><subject>Femur - drug effects</subject><subject>Femur - enzymology</subject><subject>Femur - pathology</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Glutathione Transferase - metabolism</subject><subject>Hydrogen Peroxide - metabolism</subject><subject>Internal Medicine</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Medical Education</subject><subject>Ovariectomy</subject><subject>Ovariectomy - adverse effects</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats, Wistar</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Tartrate-Resistant Acid Phosphatase - metabolism</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTuP1DAQgC0E4paDf4CQS5qE8SNx0iChFS_pJIqjoLMce8I5JPGeHa_Yf4-XPShoqEYz_mZG_oaQlwxqBqx9M9WDD4c7U_OS1SBr4OwR2bG-gaoFUI_JDlQjKiE4vyLPUpoAoGlF95RcccVb1nK2I9Pep5QTvc_GRbN-z7OJPtFDxCOuGzq63SENx1JEu4XlRP3qsi318NM7s_kj0rRFTKk8_GZHXHKkYaTG5XmjZh78Gmg0W3pOnoxmTvjiIV6T2w_vv-4_VTdfPn7ev7uprGRqqzjIYeiUsENjWaMaBgN3okc5tsr10nQd4ygGLhUfXd-Lse-ANaO0qncNiGvy-jL1EMN9xrTpxSeL82xWDDlppnrJOG-gL6i8oDaGlCKO-hD9YuJJM9Bnx3rSF8f67FiD1MVxaXv1sCEPC7q_TX-kFuDtBcDyy6PHqJP1uBZrPhaL2gX_vw3_DrCzX7018w88YZpCjmsxqJlOXIO-Pd_5fGbWCBCt-iZ-AaOPpQ8</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Muthusami, Sridhar</creator><creator>Gopalakrishnan, Vasudevan</creator><creator>Stanley, Jone A</creator><creator>Krishnamoorthy, Senthilkumar</creator><creator>Ilangovan, Ramachandran</creator><creator>Gopalakrishnan, Velliyur K</creator><creator>Srinivasan, Narasimhan</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160701</creationdate><title>Cissus quadrangularis prevented the ovariectomy induced oxidative stress in the femur of adult albino rats</title><author>Muthusami, Sridhar ; Gopalakrishnan, Vasudevan ; Stanley, Jone A ; Krishnamoorthy, Senthilkumar ; Ilangovan, Ramachandran ; Gopalakrishnan, Velliyur K ; Srinivasan, Narasimhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-204bb873cb5c157510b2d39e4f67d94a8812e3b2472fd993f98015f4c79d503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aging</topic><topic>Alkaline Phosphatase - metabolism</topic><topic>Animals</topic><topic>Bone loss</topic><topic>C. quadrangularis</topic><topic>Cissus - chemistry</topic><topic>Collagen - metabolism</topic><topic>Female</topic><topic>Femur - drug effects</topic><topic>Femur - enzymology</topic><topic>Femur - pathology</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Glutathione Transferase - metabolism</topic><topic>Hydrogen Peroxide - metabolism</topic><topic>Internal Medicine</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Medical Education</topic><topic>Ovariectomy</topic><topic>Ovariectomy - adverse effects</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats, Wistar</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Tartrate-Resistant Acid Phosphatase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muthusami, Sridhar</creatorcontrib><creatorcontrib>Gopalakrishnan, Vasudevan</creatorcontrib><creatorcontrib>Stanley, Jone A</creatorcontrib><creatorcontrib>Krishnamoorthy, Senthilkumar</creatorcontrib><creatorcontrib>Ilangovan, Ramachandran</creatorcontrib><creatorcontrib>Gopalakrishnan, Velliyur K</creatorcontrib><creatorcontrib>Srinivasan, Narasimhan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muthusami, Sridhar</au><au>Gopalakrishnan, Vasudevan</au><au>Stanley, Jone A</au><au>Krishnamoorthy, Senthilkumar</au><au>Ilangovan, Ramachandran</au><au>Gopalakrishnan, Velliyur K</au><au>Srinivasan, Narasimhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cissus quadrangularis prevented the ovariectomy induced oxidative stress in the femur of adult albino rats</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>81</volume><spage>416</spage><epage>423</epage><pages>416-423</pages><issn>0753-3322</issn><eissn>1950-6007</eissn><abstract>Abstract The increasing evidence suggesting the role of free radicals in bone resorption and bone loss prompted us to explore whether the consumption of antioxidant rich medicinal plant C. quadrangularis modifies antioxidant status in ovariectomized rats. Methods Twenty four female adult rats, 90 days old showing regular estrous cycles were used for the present study. The animals were divided into two groups. The Group-1 rats (n = 6) were sham operated and Group-II rats were bilaterally ovariectomized (n = 18) and treated with C. quadrangularis for sixty days (100 mg/ kg body weight and 250 mg/kg body weight). After sixty days, the rats were killed, femora were dissected out, minced and homogenized in Tris-HCl buffer (pH 7.4) and the supernatant was collected and used for biochemical assays. Results Ovariectomy registered a decrease (p<0.05) in the activities of SOD, GPx, GST, ALP, collagen content and increased (p<0.05) the activities of TRAP and lipid peroxidation. Simultaneous administration of C. quadrangularis maintained the enzyme activities in ovariectomized rats. Conclusion C. quadrangularis , a natural herb may be used to treat the estrogen deficiency/menopause onset and ovariectomy induced oxidative stress.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>27261621</pmid><doi>10.1016/j.biopha.2016.04.021</doi><tpages>8</tpages></addata></record> |
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| subjects | Aging Alkaline Phosphatase - metabolism Animals Bone loss C. quadrangularis Cissus - chemistry Collagen - metabolism Female Femur - drug effects Femur - enzymology Femur - pathology Glutathione Peroxidase - metabolism Glutathione Transferase - metabolism Hydrogen Peroxide - metabolism Internal Medicine Lipid Peroxidation - drug effects Medical Education Ovariectomy Ovariectomy - adverse effects Oxidative stress Oxidative Stress - drug effects Plant Extracts - pharmacology Rats, Wistar Superoxide Dismutase - metabolism Tartrate-Resistant Acid Phosphatase - metabolism |
| title | Cissus quadrangularis prevented the ovariectomy induced oxidative stress in the femur of adult albino rats |
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