Involvement of astrocyte and oligodendrocyte gene sets in migraine
Background Migraine is a common episodic brain disorder characterized by recurrent attacks of severe unilateral headache and additional neurological symptoms. Two main migraine types can be distinguished based on the presence of aura symptoms that can accompany the headache: migraine with aura and m...
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| Veröffentlicht in: | Cephalalgia 2016-06, Vol.36 (7), p.640-647 |
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| creator | Eising, Else de Leeuw, Christiaan Min, Josine L Anttila, Verneri Verheijen, Mark HG Terwindt, Gisela M Dichgans, Martin Freilinger, Tobias Kubisch, Christian Ferrari, Michel D Smit, August B de Vries, Boukje Palotie, Aarno van den Maagdenberg, Arn MJM Posthuma, Danielle |
| description | Background
Migraine is a common episodic brain disorder characterized by recurrent attacks of severe unilateral headache and additional neurological symptoms. Two main migraine types can be distinguished based on the presence of aura symptoms that can accompany the headache: migraine with aura and migraine without aura. Multiple genetic and environmental factors confer disease susceptibility. Recent genome-wide association studies (GWAS) indicate that migraine susceptibility genes are involved in various pathways, including neurotransmission, which have already been implicated in genetic studies of monogenic familial hemiplegic migraine, a subtype of migraine with aura.
Methods
To further explore the genetic background of migraine, we performed a gene set analysis of migraine GWAS data of 4954 clinic-based patients with migraine, as well as 13,390 controls. Curated sets of synaptic genes and sets of genes predominantly expressed in three glial cell types (astrocytes, microglia and oligodendrocytes) were investigated.
Discussion
Our results show that gene sets containing astrocyte- and oligodendrocyte-related genes are associated with migraine, which is especially true for gene sets involved in protein modification and signal transduction. Observed differences between migraine with aura and migraine without aura indicate that both migraine types, at least in part, seem to have a different genetic background. |
| doi_str_mv | 10.1177/0333102415618614 |
| format | Article |
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Migraine is a common episodic brain disorder characterized by recurrent attacks of severe unilateral headache and additional neurological symptoms. Two main migraine types can be distinguished based on the presence of aura symptoms that can accompany the headache: migraine with aura and migraine without aura. Multiple genetic and environmental factors confer disease susceptibility. Recent genome-wide association studies (GWAS) indicate that migraine susceptibility genes are involved in various pathways, including neurotransmission, which have already been implicated in genetic studies of monogenic familial hemiplegic migraine, a subtype of migraine with aura.
Methods
To further explore the genetic background of migraine, we performed a gene set analysis of migraine GWAS data of 4954 clinic-based patients with migraine, as well as 13,390 controls. Curated sets of synaptic genes and sets of genes predominantly expressed in three glial cell types (astrocytes, microglia and oligodendrocytes) were investigated.
Discussion
Our results show that gene sets containing astrocyte- and oligodendrocyte-related genes are associated with migraine, which is especially true for gene sets involved in protein modification and signal transduction. Observed differences between migraine with aura and migraine without aura indicate that both migraine types, at least in part, seem to have a different genetic background.</description><identifier>ISSN: 0333-1024</identifier><identifier>EISSN: 1468-2982</identifier><identifier>DOI: 10.1177/0333102415618614</identifier><identifier>PMID: 26646788</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Astrocytes ; Female ; Genome-Wide Association Study ; Genotype ; Humans ; Male ; Migraine Disorders - genetics ; Oligodendroglia ; Oligonucleotide Array Sequence Analysis</subject><ispartof>Cephalalgia, 2016-06, Vol.36 (7), p.640-647</ispartof><rights>International Headache Society 2015</rights><rights>International Headache Society 2015.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-1f7a8d12bd82ec3729e1dfd2a6f6678f870ea3dde38adc6bd75272aaeb3a6ec93</citedby><cites>FETCH-LOGICAL-c379t-1f7a8d12bd82ec3729e1dfd2a6f6678f870ea3dde38adc6bd75272aaeb3a6ec93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0333102415618614$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0333102415618614$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21966,27853,27924,27925,44945,45333</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/0333102415618614?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26646788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eising, Else</creatorcontrib><creatorcontrib>de Leeuw, Christiaan</creatorcontrib><creatorcontrib>Min, Josine L</creatorcontrib><creatorcontrib>Anttila, Verneri</creatorcontrib><creatorcontrib>Verheijen, Mark HG</creatorcontrib><creatorcontrib>Terwindt, Gisela M</creatorcontrib><creatorcontrib>Dichgans, Martin</creatorcontrib><creatorcontrib>Freilinger, Tobias</creatorcontrib><creatorcontrib>Kubisch, Christian</creatorcontrib><creatorcontrib>Ferrari, Michel D</creatorcontrib><creatorcontrib>Smit, August B</creatorcontrib><creatorcontrib>de Vries, Boukje</creatorcontrib><creatorcontrib>Palotie, Aarno</creatorcontrib><creatorcontrib>van den Maagdenberg, Arn MJM</creatorcontrib><creatorcontrib>Posthuma, Danielle</creatorcontrib><creatorcontrib>International Headache Genetics Consortium</creatorcontrib><creatorcontrib>on behalf of the International Headache Genetics Consortium</creatorcontrib><title>Involvement of astrocyte and oligodendrocyte gene sets in migraine</title><title>Cephalalgia</title><addtitle>Cephalalgia</addtitle><description>Background
Migraine is a common episodic brain disorder characterized by recurrent attacks of severe unilateral headache and additional neurological symptoms. Two main migraine types can be distinguished based on the presence of aura symptoms that can accompany the headache: migraine with aura and migraine without aura. Multiple genetic and environmental factors confer disease susceptibility. Recent genome-wide association studies (GWAS) indicate that migraine susceptibility genes are involved in various pathways, including neurotransmission, which have already been implicated in genetic studies of monogenic familial hemiplegic migraine, a subtype of migraine with aura.
Methods
To further explore the genetic background of migraine, we performed a gene set analysis of migraine GWAS data of 4954 clinic-based patients with migraine, as well as 13,390 controls. Curated sets of synaptic genes and sets of genes predominantly expressed in three glial cell types (astrocytes, microglia and oligodendrocytes) were investigated.
Discussion
Our results show that gene sets containing astrocyte- and oligodendrocyte-related genes are associated with migraine, which is especially true for gene sets involved in protein modification and signal transduction. Observed differences between migraine with aura and migraine without aura indicate that both migraine types, at least in part, seem to have a different genetic background.</description><subject>Adult</subject><subject>Astrocytes</subject><subject>Female</subject><subject>Genome-Wide Association Study</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Migraine Disorders - genetics</subject><subject>Oligodendroglia</subject><subject>Oligonucleotide Array Sequence Analysis</subject><issn>0333-1024</issn><issn>1468-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kL1PwzAQxS0EoqWwMyGPLAF_pLYzQlWgUiUWmC0nPkepErvYSaX-96RqYUBiOund7z3dPYRuKXmgVMpHwjmnhOV0LqgSND9DU5oLlbFCsXM0Payzw36CrlLaEELmgohLNGFC5EIqNUXPK78L7Q468D0ODpvUx1Dte8DGWxzapg4WvD1pNXjACfqEG4-7po6m8XCNLpxpE9yc5gx9viw_Fm_Z-v11tXhaZxWXRZ9RJ42ylJVWMRglVgC1zjIjnBhvcUoSMNxa4MrYSpRWzplkxkDJjYCq4DN0f8zdxvA1QOp116QK2tZ4CEPSVBa8IIoVckTJEa1iSCmC09vYdCbuNSX60Jz-29xouTulD2UH9tfwU9UIZEcgmRr0JgzRj9_-H_gNppZ2ig</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Eising, Else</creator><creator>de Leeuw, Christiaan</creator><creator>Min, Josine L</creator><creator>Anttila, Verneri</creator><creator>Verheijen, Mark HG</creator><creator>Terwindt, Gisela M</creator><creator>Dichgans, Martin</creator><creator>Freilinger, Tobias</creator><creator>Kubisch, Christian</creator><creator>Ferrari, Michel D</creator><creator>Smit, August B</creator><creator>de Vries, Boukje</creator><creator>Palotie, Aarno</creator><creator>van den Maagdenberg, Arn MJM</creator><creator>Posthuma, Danielle</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201606</creationdate><title>Involvement of astrocyte and oligodendrocyte gene sets in migraine</title><author>Eising, Else ; de Leeuw, Christiaan ; Min, Josine L ; Anttila, Verneri ; Verheijen, Mark HG ; Terwindt, Gisela M ; Dichgans, Martin ; Freilinger, Tobias ; Kubisch, Christian ; Ferrari, Michel D ; Smit, August B ; de Vries, Boukje ; Palotie, Aarno ; van den Maagdenberg, Arn MJM ; Posthuma, Danielle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-1f7a8d12bd82ec3729e1dfd2a6f6678f870ea3dde38adc6bd75272aaeb3a6ec93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Astrocytes</topic><topic>Female</topic><topic>Genome-Wide Association Study</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Migraine Disorders - genetics</topic><topic>Oligodendroglia</topic><topic>Oligonucleotide Array Sequence Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eising, Else</creatorcontrib><creatorcontrib>de Leeuw, Christiaan</creatorcontrib><creatorcontrib>Min, Josine L</creatorcontrib><creatorcontrib>Anttila, Verneri</creatorcontrib><creatorcontrib>Verheijen, Mark HG</creatorcontrib><creatorcontrib>Terwindt, Gisela M</creatorcontrib><creatorcontrib>Dichgans, Martin</creatorcontrib><creatorcontrib>Freilinger, Tobias</creatorcontrib><creatorcontrib>Kubisch, Christian</creatorcontrib><creatorcontrib>Ferrari, Michel D</creatorcontrib><creatorcontrib>Smit, August B</creatorcontrib><creatorcontrib>de Vries, Boukje</creatorcontrib><creatorcontrib>Palotie, Aarno</creatorcontrib><creatorcontrib>van den Maagdenberg, Arn MJM</creatorcontrib><creatorcontrib>Posthuma, Danielle</creatorcontrib><creatorcontrib>International Headache Genetics Consortium</creatorcontrib><creatorcontrib>on behalf of the International Headache Genetics Consortium</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cephalalgia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Eising, Else</au><au>de Leeuw, Christiaan</au><au>Min, Josine L</au><au>Anttila, Verneri</au><au>Verheijen, Mark HG</au><au>Terwindt, Gisela M</au><au>Dichgans, Martin</au><au>Freilinger, Tobias</au><au>Kubisch, Christian</au><au>Ferrari, Michel D</au><au>Smit, August B</au><au>de Vries, Boukje</au><au>Palotie, Aarno</au><au>van den Maagdenberg, Arn MJM</au><au>Posthuma, Danielle</au><aucorp>International Headache Genetics Consortium</aucorp><aucorp>on behalf of the International Headache Genetics Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of astrocyte and oligodendrocyte gene sets in migraine</atitle><jtitle>Cephalalgia</jtitle><addtitle>Cephalalgia</addtitle><date>2016-06</date><risdate>2016</risdate><volume>36</volume><issue>7</issue><spage>640</spage><epage>647</epage><pages>640-647</pages><issn>0333-1024</issn><eissn>1468-2982</eissn><abstract>Background
Migraine is a common episodic brain disorder characterized by recurrent attacks of severe unilateral headache and additional neurological symptoms. Two main migraine types can be distinguished based on the presence of aura symptoms that can accompany the headache: migraine with aura and migraine without aura. Multiple genetic and environmental factors confer disease susceptibility. Recent genome-wide association studies (GWAS) indicate that migraine susceptibility genes are involved in various pathways, including neurotransmission, which have already been implicated in genetic studies of monogenic familial hemiplegic migraine, a subtype of migraine with aura.
Methods
To further explore the genetic background of migraine, we performed a gene set analysis of migraine GWAS data of 4954 clinic-based patients with migraine, as well as 13,390 controls. Curated sets of synaptic genes and sets of genes predominantly expressed in three glial cell types (astrocytes, microglia and oligodendrocytes) were investigated.
Discussion
Our results show that gene sets containing astrocyte- and oligodendrocyte-related genes are associated with migraine, which is especially true for gene sets involved in protein modification and signal transduction. Observed differences between migraine with aura and migraine without aura indicate that both migraine types, at least in part, seem to have a different genetic background.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>26646788</pmid><doi>10.1177/0333102415618614</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Adult Astrocytes Female Genome-Wide Association Study Genotype Humans Male Migraine Disorders - genetics Oligodendroglia Oligonucleotide Array Sequence Analysis |
| title | Involvement of astrocyte and oligodendrocyte gene sets in migraine |
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