The Optic Nerve Head in Primary Open-Angle Glaucoma Eyes With High Myopia: Characteristics and Association With Visual Field Defects
PURPOSE:To evaluate the morphologic characteristics of optic neuropathy and its association with visual field (VF) defects in primary open-angle glaucoma (POAG) eyes with high myopia. METHODS:In this cross-sectional study, we reviewed data from 375 Taiwanese patients (375 eyes) of POAG, ages 20 to 6...
Gespeichert in:
| Veröffentlicht in: | Journal of glaucoma 2016-06, Vol.25 (6), p.e569-e575 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e575 |
|---|---|
| container_issue | 6 |
| container_start_page | e569 |
| container_title | Journal of glaucoma |
| container_volume | 25 |
| creator | Chen, Li-Wei Lan, Yu-Wen Hsieh, Jui-Wen |
| description | PURPOSE:To evaluate the morphologic characteristics of optic neuropathy and its association with visual field (VF) defects in primary open-angle glaucoma (POAG) eyes with high myopia.
METHODS:In this cross-sectional study, we reviewed data from 375 Taiwanese patients (375 eyes) of POAG, ages 20 to 60 years. Optic disc photographs were used for planimetric measurements of morphologic variables. The myopic refraction was divided into high myopia ( |
| doi_str_mv | 10.1097/IJG.0000000000000395 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1793908209</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1793908209</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3565-15815a754ab536e8cfa4fed1203232232eb9f829c6eb34dcd8fee0f65364847a3</originalsourceid><addsrcrecordid>eNp9kMlOwzAURS0EYij8AUJesgnYzmh2VYEWVIYF0y56dV6IwU2KnYC658MxCiDEAsuSLfnca71DyC5nB5zJ9PDsfHzAfq9Qxitkk8dhEkQZf1j1dxanAcuE3CBbzj0xJpgQfJ1siETyTHKxSd5vKqRXi1Yreon2FekEoaC6ptdWz8Eu_RvWwbB-NEjHBjrVzIGeLNHRe91WdKIfK3qxbBYajuioAguqRaud73MU6oIOnWuUhlY3dZ-4064DQ081moIeY4mqddtkrQTjcOfrHJDb05Ob0SSYXo3PRsNpoMI4iQMeZzyGNI5g5ofETJUQlVhwwUIRCr9xJks_rUpwFkaFKrISkZWJh6MsSiEckP2-d2Gblw5dm8-1U2gM1Nh0LuepDKX3xaRHox5VtnHOYpkveiE5Z_mn_9z7z__697G9rx-62RyLn9C3cA9kPfDWGG_KPZvuDW1eIZi2-r_7A1sOkW0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1793908209</pqid></control><display><type>article</type><title>The Optic Nerve Head in Primary Open-Angle Glaucoma Eyes With High Myopia: Characteristics and Association With Visual Field Defects</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Chen, Li-Wei ; Lan, Yu-Wen ; Hsieh, Jui-Wen</creator><creatorcontrib>Chen, Li-Wei ; Lan, Yu-Wen ; Hsieh, Jui-Wen</creatorcontrib><description>PURPOSE:To evaluate the morphologic characteristics of optic neuropathy and its association with visual field (VF) defects in primary open-angle glaucoma (POAG) eyes with high myopia.
METHODS:In this cross-sectional study, we reviewed data from 375 Taiwanese patients (375 eyes) of POAG, ages 20 to 60 years. Optic disc photographs were used for planimetric measurements of morphologic variables. The myopic refraction was divided into high myopia (<−6.0 D) and nonhigh myopia (moderate myopia to hyperopia). The optic disc area was classified as moderate (1.59 to 2.85 mm), large, and small. Differences in characteristics between groups, correlations with the disc area, and factors associated with VF defects were determined.
RESULTS:Of the 142 highly myopic eyes, 33 (23%) had a large disc, 26 (18%) had a small disc, and 55 (39%) had a tilted disc. Large discs had a higher cup-to-disc (C/D) area ratio and a higher tilt ratio; small discs had a smaller rim area and a lower tilt ratio (all P<0.05). Characteristics associated with high myopia included a smaller rim area, a higher C/D area ratio, and a lower tilt ratio (all P<0.001). In logistic regression, the refraction, the C/D area ratio, the rim area, and the tilt ratio (all P<0.05) were associated with VF defects.
CONCLUSIONS:In Taiwanese individuals with POAG, our study found that tilted, large, or small discs were prevalent in highly myopic eyes. Of these characteristics, only the disc tilt and high myopia by itself were associated with the severity of glaucomatous optic neuropathy.</description><identifier>ISSN: 1057-0829</identifier><identifier>EISSN: 1536-481X</identifier><identifier>DOI: 10.1097/IJG.0000000000000395</identifier><identifier>PMID: 26918912</identifier><language>eng</language><publisher>United States: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adult ; Cross-Sectional Studies ; Female ; Glaucoma, Open-Angle - complications ; Glaucoma, Open-Angle - diagnosis ; Glaucoma, Open-Angle - physiopathology ; Humans ; Intraocular Pressure ; Male ; Middle Aged ; Myopia - complications ; Myopia - diagnosis ; Myopia - physiopathology ; Optic Disk - pathology ; Optic Nerve Diseases - complications ; Optic Nerve Diseases - diagnosis ; Scotoma - diagnosis ; Scotoma - etiology ; Scotoma - physiopathology ; Severity of Illness Index ; Tomography, Optical Coherence ; Visual Fields - physiology ; Young Adult</subject><ispartof>Journal of glaucoma, 2016-06, Vol.25 (6), p.e569-e575</ispartof><rights>Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3565-15815a754ab536e8cfa4fed1203232232eb9f829c6eb34dcd8fee0f65364847a3</citedby><cites>FETCH-LOGICAL-c3565-15815a754ab536e8cfa4fed1203232232eb9f829c6eb34dcd8fee0f65364847a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26918912$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Li-Wei</creatorcontrib><creatorcontrib>Lan, Yu-Wen</creatorcontrib><creatorcontrib>Hsieh, Jui-Wen</creatorcontrib><title>The Optic Nerve Head in Primary Open-Angle Glaucoma Eyes With High Myopia: Characteristics and Association With Visual Field Defects</title><title>Journal of glaucoma</title><addtitle>J Glaucoma</addtitle><description>PURPOSE:To evaluate the morphologic characteristics of optic neuropathy and its association with visual field (VF) defects in primary open-angle glaucoma (POAG) eyes with high myopia.
METHODS:In this cross-sectional study, we reviewed data from 375 Taiwanese patients (375 eyes) of POAG, ages 20 to 60 years. Optic disc photographs were used for planimetric measurements of morphologic variables. The myopic refraction was divided into high myopia (<−6.0 D) and nonhigh myopia (moderate myopia to hyperopia). The optic disc area was classified as moderate (1.59 to 2.85 mm), large, and small. Differences in characteristics between groups, correlations with the disc area, and factors associated with VF defects were determined.
RESULTS:Of the 142 highly myopic eyes, 33 (23%) had a large disc, 26 (18%) had a small disc, and 55 (39%) had a tilted disc. Large discs had a higher cup-to-disc (C/D) area ratio and a higher tilt ratio; small discs had a smaller rim area and a lower tilt ratio (all P<0.05). Characteristics associated with high myopia included a smaller rim area, a higher C/D area ratio, and a lower tilt ratio (all P<0.001). In logistic regression, the refraction, the C/D area ratio, the rim area, and the tilt ratio (all P<0.05) were associated with VF defects.
CONCLUSIONS:In Taiwanese individuals with POAG, our study found that tilted, large, or small discs were prevalent in highly myopic eyes. Of these characteristics, only the disc tilt and high myopia by itself were associated with the severity of glaucomatous optic neuropathy.</description><subject>Adult</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Glaucoma, Open-Angle - complications</subject><subject>Glaucoma, Open-Angle - diagnosis</subject><subject>Glaucoma, Open-Angle - physiopathology</subject><subject>Humans</subject><subject>Intraocular Pressure</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myopia - complications</subject><subject>Myopia - diagnosis</subject><subject>Myopia - physiopathology</subject><subject>Optic Disk - pathology</subject><subject>Optic Nerve Diseases - complications</subject><subject>Optic Nerve Diseases - diagnosis</subject><subject>Scotoma - diagnosis</subject><subject>Scotoma - etiology</subject><subject>Scotoma - physiopathology</subject><subject>Severity of Illness Index</subject><subject>Tomography, Optical Coherence</subject><subject>Visual Fields - physiology</subject><subject>Young Adult</subject><issn>1057-0829</issn><issn>1536-481X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlOwzAURS0EYij8AUJesgnYzmh2VYEWVIYF0y56dV6IwU2KnYC658MxCiDEAsuSLfnca71DyC5nB5zJ9PDsfHzAfq9Qxitkk8dhEkQZf1j1dxanAcuE3CBbzj0xJpgQfJ1siETyTHKxSd5vKqRXi1Yreon2FekEoaC6ptdWz8Eu_RvWwbB-NEjHBjrVzIGeLNHRe91WdKIfK3qxbBYajuioAguqRaud73MU6oIOnWuUhlY3dZ-4064DQ081moIeY4mqddtkrQTjcOfrHJDb05Ob0SSYXo3PRsNpoMI4iQMeZzyGNI5g5ofETJUQlVhwwUIRCr9xJks_rUpwFkaFKrISkZWJh6MsSiEckP2-d2Gblw5dm8-1U2gM1Nh0LuepDKX3xaRHox5VtnHOYpkveiE5Z_mn_9z7z__697G9rx-62RyLn9C3cA9kPfDWGG_KPZvuDW1eIZi2-r_7A1sOkW0</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Chen, Li-Wei</creator><creator>Lan, Yu-Wen</creator><creator>Hsieh, Jui-Wen</creator><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160601</creationdate><title>The Optic Nerve Head in Primary Open-Angle Glaucoma Eyes With High Myopia: Characteristics and Association With Visual Field Defects</title><author>Chen, Li-Wei ; Lan, Yu-Wen ; Hsieh, Jui-Wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3565-15815a754ab536e8cfa4fed1203232232eb9f829c6eb34dcd8fee0f65364847a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Glaucoma, Open-Angle - complications</topic><topic>Glaucoma, Open-Angle - diagnosis</topic><topic>Glaucoma, Open-Angle - physiopathology</topic><topic>Humans</topic><topic>Intraocular Pressure</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myopia - complications</topic><topic>Myopia - diagnosis</topic><topic>Myopia - physiopathology</topic><topic>Optic Disk - pathology</topic><topic>Optic Nerve Diseases - complications</topic><topic>Optic Nerve Diseases - diagnosis</topic><topic>Scotoma - diagnosis</topic><topic>Scotoma - etiology</topic><topic>Scotoma - physiopathology</topic><topic>Severity of Illness Index</topic><topic>Tomography, Optical Coherence</topic><topic>Visual Fields - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Li-Wei</creatorcontrib><creatorcontrib>Lan, Yu-Wen</creatorcontrib><creatorcontrib>Hsieh, Jui-Wen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of glaucoma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Li-Wei</au><au>Lan, Yu-Wen</au><au>Hsieh, Jui-Wen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Optic Nerve Head in Primary Open-Angle Glaucoma Eyes With High Myopia: Characteristics and Association With Visual Field Defects</atitle><jtitle>Journal of glaucoma</jtitle><addtitle>J Glaucoma</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>25</volume><issue>6</issue><spage>e569</spage><epage>e575</epage><pages>e569-e575</pages><issn>1057-0829</issn><eissn>1536-481X</eissn><abstract>PURPOSE:To evaluate the morphologic characteristics of optic neuropathy and its association with visual field (VF) defects in primary open-angle glaucoma (POAG) eyes with high myopia.
METHODS:In this cross-sectional study, we reviewed data from 375 Taiwanese patients (375 eyes) of POAG, ages 20 to 60 years. Optic disc photographs were used for planimetric measurements of morphologic variables. The myopic refraction was divided into high myopia (<−6.0 D) and nonhigh myopia (moderate myopia to hyperopia). The optic disc area was classified as moderate (1.59 to 2.85 mm), large, and small. Differences in characteristics between groups, correlations with the disc area, and factors associated with VF defects were determined.
RESULTS:Of the 142 highly myopic eyes, 33 (23%) had a large disc, 26 (18%) had a small disc, and 55 (39%) had a tilted disc. Large discs had a higher cup-to-disc (C/D) area ratio and a higher tilt ratio; small discs had a smaller rim area and a lower tilt ratio (all P<0.05). Characteristics associated with high myopia included a smaller rim area, a higher C/D area ratio, and a lower tilt ratio (all P<0.001). In logistic regression, the refraction, the C/D area ratio, the rim area, and the tilt ratio (all P<0.05) were associated with VF defects.
CONCLUSIONS:In Taiwanese individuals with POAG, our study found that tilted, large, or small discs were prevalent in highly myopic eyes. Of these characteristics, only the disc tilt and high myopia by itself were associated with the severity of glaucomatous optic neuropathy.</abstract><cop>United States</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>26918912</pmid><doi>10.1097/IJG.0000000000000395</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1057-0829 |
| ispartof | Journal of glaucoma, 2016-06, Vol.25 (6), p.e569-e575 |
| issn | 1057-0829 1536-481X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1793908209 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Cross-Sectional Studies Female Glaucoma, Open-Angle - complications Glaucoma, Open-Angle - diagnosis Glaucoma, Open-Angle - physiopathology Humans Intraocular Pressure Male Middle Aged Myopia - complications Myopia - diagnosis Myopia - physiopathology Optic Disk - pathology Optic Nerve Diseases - complications Optic Nerve Diseases - diagnosis Scotoma - diagnosis Scotoma - etiology Scotoma - physiopathology Severity of Illness Index Tomography, Optical Coherence Visual Fields - physiology Young Adult |
| title | The Optic Nerve Head in Primary Open-Angle Glaucoma Eyes With High Myopia: Characteristics and Association With Visual Field Defects |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T06%3A01%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Optic%20Nerve%20Head%20in%20Primary%20Open-Angle%20Glaucoma%20Eyes%20With%20High%20Myopia:%20Characteristics%20and%20Association%20With%20Visual%20Field%20Defects&rft.jtitle=Journal%20of%20glaucoma&rft.au=Chen,%20Li-Wei&rft.date=2016-06-01&rft.volume=25&rft.issue=6&rft.spage=e569&rft.epage=e575&rft.pages=e569-e575&rft.issn=1057-0829&rft.eissn=1536-481X&rft_id=info:doi/10.1097/IJG.0000000000000395&rft_dat=%3Cproquest_cross%3E1793908209%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1793908209&rft_id=info:pmid/26918912&rfr_iscdi=true |