Impaired Right Ventricular Function in Long-Term Lymphoma Survivors
Background Cardiotoxicity from anthracyclines or cardiac radiation therapy is detrimental to left ventricular (LV) function. However, the long-term effects on right ventricular (RV) performance are largely unknown. The aim of this study was to investigate the long-term impact of cardiotoxic treatmen...
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| Veröffentlicht in: | Journal of the American Society of Echocardiography 2016-06, Vol.29 (6), p.528-536 |
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| creator | Murbraech, Klaus, MD Holte, Espen, MD Broch, Kaspar, MD Smeland, Knut B., MD Holte, Harald, MD, PhD Rösner, Assami, MD, PhD Lund, May Brit, MD, PhD Dalen, Håvard, MD, PhD Kiserud, Cecilie, MD, PhD Aakhus, Svend, MD, PhD |
| description | Background Cardiotoxicity from anthracyclines or cardiac radiation therapy is detrimental to left ventricular (LV) function. However, the long-term effects on right ventricular (RV) performance are largely unknown. The aim of this study was to investigate the long-term impact of cardiotoxic treatment on RV function among adult cancer survivors. Methods Adult lymphoma survivors (LSs) who underwent autologous hematopoietic stem cell transplantation in Norway from 1987 to 2008 were invited to undergo cardiovascular evaluation by echocardiography and cardiopulmonary exercise testing. In total, 274 LSs participated. The mean age was 56 ± 12 years, and the mean follow-up time since lymphoma diagnosis was 13 ± 6 years. Echocardiographic parameters were compared with those of age- and gender-matched control subjects from an existing large Norwegian database. RV systolic dysfunction was indicated by two or more abnormal RV systolic parameters according to current recommendations. LV systolic dysfunction was indicated by LV global longitudinal strain > −17%. Results All parameters of RV systolic function were impaired in LSs compared with control subjects ( P |
| doi_str_mv | 10.1016/j.echo.2016.02.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1793907834</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0894731716001280</els_id><sourcerecordid>1793907834</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-3ac958cd504624f57945322bf410abdf69e51212c082a7d287488d5b0c9eb2883</originalsourceid><addsrcrecordid>eNp9kUGL1DAUx4Mo7rj6BTxIj15aX9KkSUAEGVxdGBDc1WtI09edjG0zJu3AfHtTZvXgwdN7h9__D-_3CHlNoaJAm3eHCt0-VCzvFbAKKH9CNhS0LBupxVOyAaV5KWsqr8iLlA4AIBTAc3LFJNRKULEh29vxaH3ErvjmH_Zz8QOnOXq3DDYWN8vkZh-mwk_FLkwP5T3Gsdidx-M-jLa4W-LJn0JML8mz3g4JXz3Oa_L95tP99ku5-_r5dvtxVzpO6VzW1mmhXCeAN4z3QmouasbanlOwbdc3GgVllDlQzMqOKcmV6kQLTmPLlKqvydtL7zGGXwum2Yw-ORwGO2FYkqFS1xqkqnlG2QV1MaQUsTfH6Ecbz4aCWeWZg1nlmVWeAWayvBx689i_tCN2fyN_bGXg_QXAfOXJYzTJeZwcdtmgm00X_P_7P_wTd4OfvLPDTzxjOoQlTtmfoSblgLlb37d-jzYAlCmofwMjkJOt</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1793907834</pqid></control><display><type>article</type><title>Impaired Right Ventricular Function in Long-Term Lymphoma Survivors</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Murbraech, Klaus, MD ; Holte, Espen, MD ; Broch, Kaspar, MD ; Smeland, Knut B., MD ; Holte, Harald, MD, PhD ; Rösner, Assami, MD, PhD ; Lund, May Brit, MD, PhD ; Dalen, Håvard, MD, PhD ; Kiserud, Cecilie, MD, PhD ; Aakhus, Svend, MD, PhD</creator><creatorcontrib>Murbraech, Klaus, MD ; Holte, Espen, MD ; Broch, Kaspar, MD ; Smeland, Knut B., MD ; Holte, Harald, MD, PhD ; Rösner, Assami, MD, PhD ; Lund, May Brit, MD, PhD ; Dalen, Håvard, MD, PhD ; Kiserud, Cecilie, MD, PhD ; Aakhus, Svend, MD, PhD</creatorcontrib><description>Background Cardiotoxicity from anthracyclines or cardiac radiation therapy is detrimental to left ventricular (LV) function. However, the long-term effects on right ventricular (RV) performance are largely unknown. The aim of this study was to investigate the long-term impact of cardiotoxic treatment on RV function among adult cancer survivors. Methods Adult lymphoma survivors (LSs) who underwent autologous hematopoietic stem cell transplantation in Norway from 1987 to 2008 were invited to undergo cardiovascular evaluation by echocardiography and cardiopulmonary exercise testing. In total, 274 LSs participated. The mean age was 56 ± 12 years, and the mean follow-up time since lymphoma diagnosis was 13 ± 6 years. Echocardiographic parameters were compared with those of age- and gender-matched control subjects from an existing large Norwegian database. RV systolic dysfunction was indicated by two or more abnormal RV systolic parameters according to current recommendations. LV systolic dysfunction was indicated by LV global longitudinal strain > −17%. Results All parameters of RV systolic function were impaired in LSs compared with control subjects ( P < .01 for all). The most pronounced difference was observed for tricuspid annular plane systolic excursion: 22.9 ± 4.1 versus 27.1 ± 4.2 mm. Greater cardiotoxic treatment burden was associated with larger RV functional impairment. Tricuspid annular plane systolic excursion correlated with peak oxygen consumption ( r = 0.23, P = .001). RV systolic performance was associated with LV systolic function ( r = 0.49, P < .001 for tricuspid annular plane systolic excursion vs LV global longitudinal strain), but a greater proportion of patients had LV dysfunction (30.8%) compared with RV dysfunction (6.2%) ( P < .001). Conclusions RV systolic function was impaired in LSs. The association between RV and LV function indicates a global, long-term cardiotoxic effect. However, RV dysfunction was less prevalent than LV dysfunction.</description><identifier>ISSN: 0894-7317</identifier><identifier>EISSN: 1097-6795</identifier><identifier>DOI: 10.1016/j.echo.2016.02.014</identifier><identifier>PMID: 27038515</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Anthracyclines ; Cancer Survivors - statistics & numerical data ; Cardiovascular ; Causality ; Chemoradiotherapy - utilization ; Comorbidity ; Cross-Sectional Studies ; Echocardiography ; Echocardiography - statistics & numerical data ; Humans ; Incidence ; Longitudinal Studies ; Lymphoma - diagnostic imaging ; Lymphoma - epidemiology ; Lymphoma - therapy ; Lymphoma survivors ; Middle Aged ; Norway - epidemiology ; Radiotherapy ; Reproducibility of Results ; Right ventricle ; Risk Factors ; Sensitivity and Specificity ; Stroke Volume ; Treatment Outcome ; Ventricular Dysfunction, Right - diagnostic imaging ; Ventricular Dysfunction, Right - epidemiology</subject><ispartof>Journal of the American Society of Echocardiography, 2016-06, Vol.29 (6), p.528-536</ispartof><rights>American Society of Echocardiography</rights><rights>2016 American Society of Echocardiography</rights><rights>Copyright © 2016 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-3ac958cd504624f57945322bf410abdf69e51212c082a7d287488d5b0c9eb2883</citedby><cites>FETCH-LOGICAL-c411t-3ac958cd504624f57945322bf410abdf69e51212c082a7d287488d5b0c9eb2883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0894731716001280$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27038515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murbraech, Klaus, MD</creatorcontrib><creatorcontrib>Holte, Espen, MD</creatorcontrib><creatorcontrib>Broch, Kaspar, MD</creatorcontrib><creatorcontrib>Smeland, Knut B., MD</creatorcontrib><creatorcontrib>Holte, Harald, MD, PhD</creatorcontrib><creatorcontrib>Rösner, Assami, MD, PhD</creatorcontrib><creatorcontrib>Lund, May Brit, MD, PhD</creatorcontrib><creatorcontrib>Dalen, Håvard, MD, PhD</creatorcontrib><creatorcontrib>Kiserud, Cecilie, MD, PhD</creatorcontrib><creatorcontrib>Aakhus, Svend, MD, PhD</creatorcontrib><title>Impaired Right Ventricular Function in Long-Term Lymphoma Survivors</title><title>Journal of the American Society of Echocardiography</title><addtitle>J Am Soc Echocardiogr</addtitle><description>Background Cardiotoxicity from anthracyclines or cardiac radiation therapy is detrimental to left ventricular (LV) function. However, the long-term effects on right ventricular (RV) performance are largely unknown. The aim of this study was to investigate the long-term impact of cardiotoxic treatment on RV function among adult cancer survivors. Methods Adult lymphoma survivors (LSs) who underwent autologous hematopoietic stem cell transplantation in Norway from 1987 to 2008 were invited to undergo cardiovascular evaluation by echocardiography and cardiopulmonary exercise testing. In total, 274 LSs participated. The mean age was 56 ± 12 years, and the mean follow-up time since lymphoma diagnosis was 13 ± 6 years. Echocardiographic parameters were compared with those of age- and gender-matched control subjects from an existing large Norwegian database. RV systolic dysfunction was indicated by two or more abnormal RV systolic parameters according to current recommendations. LV systolic dysfunction was indicated by LV global longitudinal strain > −17%. Results All parameters of RV systolic function were impaired in LSs compared with control subjects ( P < .01 for all). The most pronounced difference was observed for tricuspid annular plane systolic excursion: 22.9 ± 4.1 versus 27.1 ± 4.2 mm. Greater cardiotoxic treatment burden was associated with larger RV functional impairment. Tricuspid annular plane systolic excursion correlated with peak oxygen consumption ( r = 0.23, P = .001). RV systolic performance was associated with LV systolic function ( r = 0.49, P < .001 for tricuspid annular plane systolic excursion vs LV global longitudinal strain), but a greater proportion of patients had LV dysfunction (30.8%) compared with RV dysfunction (6.2%) ( P < .001). Conclusions RV systolic function was impaired in LSs. The association between RV and LV function indicates a global, long-term cardiotoxic effect. However, RV dysfunction was less prevalent than LV dysfunction.</description><subject>Anthracyclines</subject><subject>Cancer Survivors - statistics & numerical data</subject><subject>Cardiovascular</subject><subject>Causality</subject><subject>Chemoradiotherapy - utilization</subject><subject>Comorbidity</subject><subject>Cross-Sectional Studies</subject><subject>Echocardiography</subject><subject>Echocardiography - statistics & numerical data</subject><subject>Humans</subject><subject>Incidence</subject><subject>Longitudinal Studies</subject><subject>Lymphoma - diagnostic imaging</subject><subject>Lymphoma - epidemiology</subject><subject>Lymphoma - therapy</subject><subject>Lymphoma survivors</subject><subject>Middle Aged</subject><subject>Norway - epidemiology</subject><subject>Radiotherapy</subject><subject>Reproducibility of Results</subject><subject>Right ventricle</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Stroke Volume</subject><subject>Treatment Outcome</subject><subject>Ventricular Dysfunction, Right - diagnostic imaging</subject><subject>Ventricular Dysfunction, Right - epidemiology</subject><issn>0894-7317</issn><issn>1097-6795</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGL1DAUx4Mo7rj6BTxIj15aX9KkSUAEGVxdGBDc1WtI09edjG0zJu3AfHtTZvXgwdN7h9__D-_3CHlNoaJAm3eHCt0-VCzvFbAKKH9CNhS0LBupxVOyAaV5KWsqr8iLlA4AIBTAc3LFJNRKULEh29vxaH3ErvjmH_Zz8QOnOXq3DDYWN8vkZh-mwk_FLkwP5T3Gsdidx-M-jLa4W-LJn0JML8mz3g4JXz3Oa_L95tP99ku5-_r5dvtxVzpO6VzW1mmhXCeAN4z3QmouasbanlOwbdc3GgVllDlQzMqOKcmV6kQLTmPLlKqvydtL7zGGXwum2Yw-ORwGO2FYkqFS1xqkqnlG2QV1MaQUsTfH6Ecbz4aCWeWZg1nlmVWeAWayvBx689i_tCN2fyN_bGXg_QXAfOXJYzTJeZwcdtmgm00X_P_7P_wTd4OfvLPDTzxjOoQlTtmfoSblgLlb37d-jzYAlCmofwMjkJOt</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Murbraech, Klaus, MD</creator><creator>Holte, Espen, MD</creator><creator>Broch, Kaspar, MD</creator><creator>Smeland, Knut B., MD</creator><creator>Holte, Harald, MD, PhD</creator><creator>Rösner, Assami, MD, PhD</creator><creator>Lund, May Brit, MD, PhD</creator><creator>Dalen, Håvard, MD, PhD</creator><creator>Kiserud, Cecilie, MD, PhD</creator><creator>Aakhus, Svend, MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160601</creationdate><title>Impaired Right Ventricular Function in Long-Term Lymphoma Survivors</title><author>Murbraech, Klaus, MD ; Holte, Espen, MD ; Broch, Kaspar, MD ; Smeland, Knut B., MD ; Holte, Harald, MD, PhD ; Rösner, Assami, MD, PhD ; Lund, May Brit, MD, PhD ; Dalen, Håvard, MD, PhD ; Kiserud, Cecilie, MD, PhD ; Aakhus, Svend, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-3ac958cd504624f57945322bf410abdf69e51212c082a7d287488d5b0c9eb2883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Anthracyclines</topic><topic>Cancer Survivors - statistics & numerical data</topic><topic>Cardiovascular</topic><topic>Causality</topic><topic>Chemoradiotherapy - utilization</topic><topic>Comorbidity</topic><topic>Cross-Sectional Studies</topic><topic>Echocardiography</topic><topic>Echocardiography - statistics & numerical data</topic><topic>Humans</topic><topic>Incidence</topic><topic>Longitudinal Studies</topic><topic>Lymphoma - diagnostic imaging</topic><topic>Lymphoma - epidemiology</topic><topic>Lymphoma - therapy</topic><topic>Lymphoma survivors</topic><topic>Middle Aged</topic><topic>Norway - epidemiology</topic><topic>Radiotherapy</topic><topic>Reproducibility of Results</topic><topic>Right ventricle</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><topic>Stroke Volume</topic><topic>Treatment Outcome</topic><topic>Ventricular Dysfunction, Right - diagnostic imaging</topic><topic>Ventricular Dysfunction, Right - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murbraech, Klaus, MD</creatorcontrib><creatorcontrib>Holte, Espen, MD</creatorcontrib><creatorcontrib>Broch, Kaspar, MD</creatorcontrib><creatorcontrib>Smeland, Knut B., MD</creatorcontrib><creatorcontrib>Holte, Harald, MD, PhD</creatorcontrib><creatorcontrib>Rösner, Assami, MD, PhD</creatorcontrib><creatorcontrib>Lund, May Brit, MD, PhD</creatorcontrib><creatorcontrib>Dalen, Håvard, MD, PhD</creatorcontrib><creatorcontrib>Kiserud, Cecilie, MD, PhD</creatorcontrib><creatorcontrib>Aakhus, Svend, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Society of Echocardiography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murbraech, Klaus, MD</au><au>Holte, Espen, MD</au><au>Broch, Kaspar, MD</au><au>Smeland, Knut B., MD</au><au>Holte, Harald, MD, PhD</au><au>Rösner, Assami, MD, PhD</au><au>Lund, May Brit, MD, PhD</au><au>Dalen, Håvard, MD, PhD</au><au>Kiserud, Cecilie, MD, PhD</au><au>Aakhus, Svend, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired Right Ventricular Function in Long-Term Lymphoma Survivors</atitle><jtitle>Journal of the American Society of Echocardiography</jtitle><addtitle>J Am Soc Echocardiogr</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>29</volume><issue>6</issue><spage>528</spage><epage>536</epage><pages>528-536</pages><issn>0894-7317</issn><eissn>1097-6795</eissn><abstract>Background Cardiotoxicity from anthracyclines or cardiac radiation therapy is detrimental to left ventricular (LV) function. However, the long-term effects on right ventricular (RV) performance are largely unknown. The aim of this study was to investigate the long-term impact of cardiotoxic treatment on RV function among adult cancer survivors. Methods Adult lymphoma survivors (LSs) who underwent autologous hematopoietic stem cell transplantation in Norway from 1987 to 2008 were invited to undergo cardiovascular evaluation by echocardiography and cardiopulmonary exercise testing. In total, 274 LSs participated. The mean age was 56 ± 12 years, and the mean follow-up time since lymphoma diagnosis was 13 ± 6 years. Echocardiographic parameters were compared with those of age- and gender-matched control subjects from an existing large Norwegian database. RV systolic dysfunction was indicated by two or more abnormal RV systolic parameters according to current recommendations. LV systolic dysfunction was indicated by LV global longitudinal strain > −17%. Results All parameters of RV systolic function were impaired in LSs compared with control subjects ( P < .01 for all). The most pronounced difference was observed for tricuspid annular plane systolic excursion: 22.9 ± 4.1 versus 27.1 ± 4.2 mm. Greater cardiotoxic treatment burden was associated with larger RV functional impairment. Tricuspid annular plane systolic excursion correlated with peak oxygen consumption ( r = 0.23, P = .001). RV systolic performance was associated with LV systolic function ( r = 0.49, P < .001 for tricuspid annular plane systolic excursion vs LV global longitudinal strain), but a greater proportion of patients had LV dysfunction (30.8%) compared with RV dysfunction (6.2%) ( P < .001). Conclusions RV systolic function was impaired in LSs. The association between RV and LV function indicates a global, long-term cardiotoxic effect. However, RV dysfunction was less prevalent than LV dysfunction.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27038515</pmid><doi>10.1016/j.echo.2016.02.014</doi><tpages>9</tpages></addata></record> |
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| subjects | Anthracyclines Cancer Survivors - statistics & numerical data Cardiovascular Causality Chemoradiotherapy - utilization Comorbidity Cross-Sectional Studies Echocardiography Echocardiography - statistics & numerical data Humans Incidence Longitudinal Studies Lymphoma - diagnostic imaging Lymphoma - epidemiology Lymphoma - therapy Lymphoma survivors Middle Aged Norway - epidemiology Radiotherapy Reproducibility of Results Right ventricle Risk Factors Sensitivity and Specificity Stroke Volume Treatment Outcome Ventricular Dysfunction, Right - diagnostic imaging Ventricular Dysfunction, Right - epidemiology |
| title | Impaired Right Ventricular Function in Long-Term Lymphoma Survivors |
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