The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample

Introduction The objective of the study was to follow up and to test whether 12 previously identified migraine-associated single nucleotide polymorphisms were associated as risk factors and/or modifying factors for severe migraine traits in a Danish clinic-based population. Methods Semi-structured m...

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Veröffentlicht in:Cephalalgia 2016-06, Vol.36 (7), p.615-623
Hauptverfasser: Esserlind, Ann-Louise, Christensen, Anne Francke, Steinberg, Stacy, Grarup, Niels, Pedersen, Oluf, Hansen, Torben, Werge, Thomas, Hansen, Thomas Folkmann, Husemoen, Lise Lotte N, Linneberg, Allan, Budtz-Jorgensen, Esben, Westergaard, Maria Lurenda, Stefansson, Hreinn, Olesen, Jes
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container_end_page 623
container_issue 7
container_start_page 615
container_title Cephalalgia
container_volume 36
creator Esserlind, Ann-Louise
Christensen, Anne Francke
Steinberg, Stacy
Grarup, Niels
Pedersen, Oluf
Hansen, Torben
Werge, Thomas
Hansen, Thomas Folkmann
Husemoen, Lise Lotte N
Linneberg, Allan
Budtz-Jorgensen, Esben
Westergaard, Maria Lurenda
Stefansson, Hreinn
Olesen, Jes
description Introduction The objective of the study was to follow up and to test whether 12 previously identified migraine-associated single nucleotide polymorphisms were associated as risk factors and/or modifying factors for severe migraine traits in a Danish clinic-based population. Methods Semi-structured migraine interviews, blood sampling and genotyping were performed on 1806 unrelated migraineurs recruited from the Danish Headache Center. Genotyping was also performed on a control group of 6415 people with no history of migraine. Association analyses were carried out using logistic regression and odds ratios were calculated assuming an additive model for risk. The proxies for severe migraine traits (early onset of migraine; many lifetime attacks, prolonged migraine and tendency to chronification of migraine) were tested against the 12 single nucleotide polymorphisms and a combined genetic score in both a case-control and case-only logistic regression model. Results We successfully replicated five out of the 12 previously reported loci and confirmed the same direction of effects for all the 12 single nucleotide polymorphisms. In line with the recently published genome-wide association meta-analysis, the associations were significant for all migraine and migraine without aura but not for migraine with typical aura. Two single nucleotide polymorphisms (rs2274316 and rs11172113) conferred risk of many lifetime attacks inthe case-control analysis. In the case-only analysis, only three single nucleotide polymorphisms showed nominal association with many lifetime attacks and prolonged migraine attacks. Conclusion Our study supports previously reported findings on the association of several single nucleotide polymorphisms with migraine. It also suggests that the migraine susceptibility loci may be risk factors for severe migraine traits.
doi_str_mv 10.1177/0333102415570492
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Methods Semi-structured migraine interviews, blood sampling and genotyping were performed on 1806 unrelated migraineurs recruited from the Danish Headache Center. Genotyping was also performed on a control group of 6415 people with no history of migraine. Association analyses were carried out using logistic regression and odds ratios were calculated assuming an additive model for risk. The proxies for severe migraine traits (early onset of migraine; many lifetime attacks, prolonged migraine and tendency to chronification of migraine) were tested against the 12 single nucleotide polymorphisms and a combined genetic score in both a case-control and case-only logistic regression model. Results We successfully replicated five out of the 12 previously reported loci and confirmed the same direction of effects for all the 12 single nucleotide polymorphisms. In line with the recently published genome-wide association meta-analysis, the associations were significant for all migraine and migraine without aura but not for migraine with typical aura. Two single nucleotide polymorphisms (rs2274316 and rs11172113) conferred risk of many lifetime attacks inthe case-control analysis. In the case-only analysis, only three single nucleotide polymorphisms showed nominal association with many lifetime attacks and prolonged migraine attacks. Conclusion Our study supports previously reported findings on the association of several single nucleotide polymorphisms with migraine. It also suggests that the migraine susceptibility loci may be risk factors for severe migraine traits.</description><identifier>ISSN: 0333-1024</identifier><identifier>EISSN: 1468-2982</identifier><identifier>DOI: 10.1177/0333102415570492</identifier><identifier>PMID: 25667298</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Female ; Genetic Predisposition to Disease - genetics ; Genotype ; Humans ; Male ; Middle Aged ; Migraine Disorders - genetics ; Phenotype ; Polymorphism, Single Nucleotide ; Risk Factors</subject><ispartof>Cephalalgia, 2016-06, Vol.36 (7), p.615-623</ispartof><rights>International Headache Society 2015</rights><rights>International Headache Society 2015.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-c5f8938881bfc88f898ddfcd91f9d8b97b3b42a59df485f08f97aee3045278783</citedby><cites>FETCH-LOGICAL-c403t-c5f8938881bfc88f898ddfcd91f9d8b97b3b42a59df485f08f97aee3045278783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0333102415570492$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0333102415570492$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21966,27853,27924,27925,44945,45333</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/0333102415570492?utm_source=summon&amp;utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25667298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Esserlind, Ann-Louise</creatorcontrib><creatorcontrib>Christensen, Anne Francke</creatorcontrib><creatorcontrib>Steinberg, Stacy</creatorcontrib><creatorcontrib>Grarup, Niels</creatorcontrib><creatorcontrib>Pedersen, Oluf</creatorcontrib><creatorcontrib>Hansen, Torben</creatorcontrib><creatorcontrib>Werge, Thomas</creatorcontrib><creatorcontrib>Hansen, Thomas Folkmann</creatorcontrib><creatorcontrib>Husemoen, Lise Lotte N</creatorcontrib><creatorcontrib>Linneberg, Allan</creatorcontrib><creatorcontrib>Budtz-Jorgensen, Esben</creatorcontrib><creatorcontrib>Westergaard, Maria Lurenda</creatorcontrib><creatorcontrib>Stefansson, Hreinn</creatorcontrib><creatorcontrib>Olesen, Jes</creatorcontrib><title>The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample</title><title>Cephalalgia</title><addtitle>Cephalalgia</addtitle><description>Introduction The objective of the study was to follow up and to test whether 12 previously identified migraine-associated single nucleotide polymorphisms were associated as risk factors and/or modifying factors for severe migraine traits in a Danish clinic-based population. Methods Semi-structured migraine interviews, blood sampling and genotyping were performed on 1806 unrelated migraineurs recruited from the Danish Headache Center. Genotyping was also performed on a control group of 6415 people with no history of migraine. Association analyses were carried out using logistic regression and odds ratios were calculated assuming an additive model for risk. The proxies for severe migraine traits (early onset of migraine; many lifetime attacks, prolonged migraine and tendency to chronification of migraine) were tested against the 12 single nucleotide polymorphisms and a combined genetic score in both a case-control and case-only logistic regression model. Results We successfully replicated five out of the 12 previously reported loci and confirmed the same direction of effects for all the 12 single nucleotide polymorphisms. In line with the recently published genome-wide association meta-analysis, the associations were significant for all migraine and migraine without aura but not for migraine with typical aura. Two single nucleotide polymorphisms (rs2274316 and rs11172113) conferred risk of many lifetime attacks inthe case-control analysis. In the case-only analysis, only three single nucleotide polymorphisms showed nominal association with many lifetime attacks and prolonged migraine attacks. Conclusion Our study supports previously reported findings on the association of several single nucleotide polymorphisms with migraine. It also suggests that the migraine susceptibility loci may be risk factors for severe migraine traits.</description><subject>Adult</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Migraine Disorders - genetics</subject><subject>Phenotype</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk Factors</subject><issn>0333-1024</issn><issn>1468-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9LwzAUx4Mobk7vniRHL9WkaZvkKMNfMPAyzyVNX7aMNO2aVtl_b8amiODp8fh-vl_e-yJ0TckdpZzfE8YYJWlG85yTTKYnaEqzQiSpFOkpmu7lZK9P0EUIG0JIXpDiHE3SvCh4hKZou1wDViG02qrBth5XMHwCeKyVr22tBsCNXfXKesBhDBq6wVbW2WGHXfTgSOEAH9D_4ro1-HbYdYCtxwprZ73VyuGgms7BJTozygW4Os4Zen96XM5fksXb8-v8YZHojLAh0bkRkgkhaGW0EHERdW10LamRtagkr1iVpSqXtclEbogwkisARrI85YILNkO3h9yub7cjhKFsbLzfOeWhHUNJuWSSFJxlESUHVPdtCD2Ysutto_pdSUm5L7r8W3S03BzTx6qB-sfw3WwEkgMQ1ArKTTv2Pn77f-AX7WSHJQ</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Esserlind, Ann-Louise</creator><creator>Christensen, Anne Francke</creator><creator>Steinberg, Stacy</creator><creator>Grarup, Niels</creator><creator>Pedersen, Oluf</creator><creator>Hansen, Torben</creator><creator>Werge, Thomas</creator><creator>Hansen, Thomas Folkmann</creator><creator>Husemoen, Lise Lotte N</creator><creator>Linneberg, Allan</creator><creator>Budtz-Jorgensen, Esben</creator><creator>Westergaard, Maria Lurenda</creator><creator>Stefansson, Hreinn</creator><creator>Olesen, Jes</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160601</creationdate><title>The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample</title><author>Esserlind, Ann-Louise ; Christensen, Anne Francke ; Steinberg, Stacy ; Grarup, Niels ; Pedersen, Oluf ; Hansen, Torben ; Werge, Thomas ; Hansen, Thomas Folkmann ; Husemoen, Lise Lotte N ; Linneberg, Allan ; Budtz-Jorgensen, Esben ; Westergaard, Maria Lurenda ; Stefansson, Hreinn ; Olesen, Jes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-c5f8938881bfc88f898ddfcd91f9d8b97b3b42a59df485f08f97aee3045278783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Migraine Disorders - genetics</topic><topic>Phenotype</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Esserlind, Ann-Louise</creatorcontrib><creatorcontrib>Christensen, Anne Francke</creatorcontrib><creatorcontrib>Steinberg, Stacy</creatorcontrib><creatorcontrib>Grarup, Niels</creatorcontrib><creatorcontrib>Pedersen, Oluf</creatorcontrib><creatorcontrib>Hansen, Torben</creatorcontrib><creatorcontrib>Werge, Thomas</creatorcontrib><creatorcontrib>Hansen, Thomas Folkmann</creatorcontrib><creatorcontrib>Husemoen, Lise Lotte N</creatorcontrib><creatorcontrib>Linneberg, Allan</creatorcontrib><creatorcontrib>Budtz-Jorgensen, Esben</creatorcontrib><creatorcontrib>Westergaard, Maria Lurenda</creatorcontrib><creatorcontrib>Stefansson, Hreinn</creatorcontrib><creatorcontrib>Olesen, Jes</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cephalalgia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Esserlind, Ann-Louise</au><au>Christensen, Anne Francke</au><au>Steinberg, Stacy</au><au>Grarup, Niels</au><au>Pedersen, Oluf</au><au>Hansen, Torben</au><au>Werge, Thomas</au><au>Hansen, Thomas Folkmann</au><au>Husemoen, Lise Lotte N</au><au>Linneberg, Allan</au><au>Budtz-Jorgensen, Esben</au><au>Westergaard, Maria Lurenda</au><au>Stefansson, Hreinn</au><au>Olesen, Jes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample</atitle><jtitle>Cephalalgia</jtitle><addtitle>Cephalalgia</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>36</volume><issue>7</issue><spage>615</spage><epage>623</epage><pages>615-623</pages><issn>0333-1024</issn><eissn>1468-2982</eissn><abstract>Introduction The objective of the study was to follow up and to test whether 12 previously identified migraine-associated single nucleotide polymorphisms were associated as risk factors and/or modifying factors for severe migraine traits in a Danish clinic-based population. Methods Semi-structured migraine interviews, blood sampling and genotyping were performed on 1806 unrelated migraineurs recruited from the Danish Headache Center. Genotyping was also performed on a control group of 6415 people with no history of migraine. Association analyses were carried out using logistic regression and odds ratios were calculated assuming an additive model for risk. The proxies for severe migraine traits (early onset of migraine; many lifetime attacks, prolonged migraine and tendency to chronification of migraine) were tested against the 12 single nucleotide polymorphisms and a combined genetic score in both a case-control and case-only logistic regression model. Results We successfully replicated five out of the 12 previously reported loci and confirmed the same direction of effects for all the 12 single nucleotide polymorphisms. In line with the recently published genome-wide association meta-analysis, the associations were significant for all migraine and migraine without aura but not for migraine with typical aura. Two single nucleotide polymorphisms (rs2274316 and rs11172113) conferred risk of many lifetime attacks inthe case-control analysis. In the case-only analysis, only three single nucleotide polymorphisms showed nominal association with many lifetime attacks and prolonged migraine attacks. Conclusion Our study supports previously reported findings on the association of several single nucleotide polymorphisms with migraine. It also suggests that the migraine susceptibility loci may be risk factors for severe migraine traits.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>25667298</pmid><doi>10.1177/0333102415570492</doi><tpages>9</tpages></addata></record>
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source SAGE Journals
subjects Adult
Female
Genetic Predisposition to Disease - genetics
Genotype
Humans
Male
Middle Aged
Migraine Disorders - genetics
Phenotype
Polymorphism, Single Nucleotide
Risk Factors
title The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample
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