Nitric oxide synthetic pathway and cGMP levels are altered in red blood cells from end-stage renal disease patients

Red blood cells (RBCs) enzymatically produce nitric oxide (NO) by a functional RBC-nitric oxide synthase (RBC-NOS). NO is a vascular key regulatory molecule. In RBCs its generation is complex and influenced by several factors, including insulin, acetylcholine, and calcium. NO availability is reduced...

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Veröffentlicht in:	Molecular and cellular biochemistry 2016-06, Vol.417 (1-2), p.155-167
Hauptverfasser:	Di Pietro, Natalia, Giardinelli, Annalisa, Sirolli, Vittorio, Riganti, Chiara, Di Tomo, Pamela, Gazzano, Elena, Di Silvestre, Sara, Panknin, Christina, Cortese-Krott, Miriam M., Csonka, Csaba, Kelm, Malte, Ferdinandy, Péter, Bonomini, Mario, Pandolfi, Assunta
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Bioavailability Biochemistry Biomedical and Life Sciences Calcium Calmodulin - metabolism Cardiology Chronic kidney failure Cyclic GMP - metabolism Cyclic guanosine monophosphate Drug resistance Endothelium Enzymes Erythrocytes Erythrocytes - metabolism Erythrocytes - pathology Female Heat shock proteins HSP90 Heat-Shock Proteins - metabolism Humans Insulin Kidney diseases Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - pathology Kidney Failure, Chronic - therapy Life Sciences Male Medical Biochemistry Middle Aged Multidrug Resistance-Associated Proteins - biosynthesis Nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase Type III - metabolism Oncology Type 2 diabetes
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