The anti‐inflammatory effects of 1,25‐dihydroxyvitamin D3 on Th2 cells in vivo are due in part to the control of integrin‐mediated T lymphocyte homing

The fat soluble vitamin D3 metabolite 1,25‐dihydroxyvitamin D3 [1,25(OH)2D3], and its nuclear receptor play an important role in regulating immune responses. While 1,25(OH)2D3 is known to inhibit transcription of cytokine genes that are required for Th1 differentiation or are products of differentia...

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Veröffentlicht in:	European journal of immunology 2004-04, Vol.34 (4), p.1068-1076
Hauptverfasser:	Topilski, Ian, Flaishon, Liat, Naveh, Yaron, Harmelin, Alon, Levo, Yoram, Shachar, Idit
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asthma Asthma - chemically induced Asthma - immunology Asthma - physiopathology Bronchoalveolar Lavage Fluid - chemistry Calcitriol - pharmacology CD4 T cells Cell Differentiation - immunology Cell Movement - drug effects Cell Movement - immunology Cytoskeleton - drug effects Cytoskeleton - immunology Cytoskeleton rearrangement Disease Models, Animal Inflammation - immunology Integrins - immunology Interleukin-4 - analysis Lung - immunology Lung - pathology Mice Migration Ovalbumin - immunology Ovalbumin - toxicity Th2 cells Th2 Cells - immunology Vitamin D
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