Paroxetine does not improve symptoms and impairs cognition in frontotemporal dementia: a double-blind randomized controlled trial

Patients with frontal variant frontotemporal dementia (fvFTD) present with disinhibition, impulsiveness, apathy, altered appetite and stereotypic behaviors. A non-randomized clinical trial found improvement in these symptoms after treatment with a selective serotonin reuptake inhibitor (SSRI). We ai...

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Veröffentlicht in:	Psychopharmacologia 2004-04, Vol.172 (4), p.400-408
Hauptverfasser:	DEAKIN, J. B, RAHMAN, S, NESTOR, P. J, HODGES, J. R, SAHAKIAN, B. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Association Learning - drug effects Attention - drug effects Biological and medical sciences Cognition - drug effects Dementia Dementia - drug therapy Double-Blind Method Female Frontal Lobe Fundamental and applied biological sciences. Psychology Humans Male Medical sciences Memory - drug effects Middle Aged Neuropharmacology Paroxetine - adverse effects Paroxetine - therapeutic use Pharmacology. Drug treatments Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Reaction Time - drug effects Risk-Taking Serotonin Uptake Inhibitors - adverse effects Serotonin Uptake Inhibitors - therapeutic use Surveys and Questionnaires Time Factors Visual Perception - drug effects
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