High-dose intravenous paraoxon exposure does not cause organophosphate-induced delayed neuropathy (OPIDN) in mini pigs

Organophosphorus compounds are inhibitors of serine hydrolases. Some of these compounds produce, in addition to their high acute toxicity, a more persistent effect: organophosphate‐induced delayed neuropathy (OPIDN). The putative molecular entity whose inhibition is thought to be responsible for OPI...

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Veröffentlicht in:	Journal of applied toxicology 2001-07, Vol.21 (4), p.263-268
Hauptverfasser:	Petroianu, G., Hardt, F., Toomes, M., Bergler, W., Rüfer, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia - chemically induced Ataxia - therapy Biological and medical sciences Biomarkers Carboxylesterase Carboxylic Ester Hydrolases - antagonists & inhibitors Carboxylic Ester Hydrolases - metabolism Female Follow-Up Studies Hypoxia - prevention & control Infusions, Intravenous Insecticides - toxicity Male Medical sciences neuropathy target esterase organophosphate-induced delayed neuropathy organophosphate-induced delayed neuropathy (OPIDN) Paralysis - chemically induced Paralysis - therapy paraoxon Paraoxon - administration & dosage Paraoxon - toxicity Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - enzymology Peripheral Nervous System Diseases - therapy Pesticides, fertilizers and other agrochemicals toxicology Reaction Time - drug effects Swine Swine, Miniature Time Factors Toxicology
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