Impact of caffeic acid phenethyl ester treatment on vancomycin-induced pancreatic damage in rats
This study investigates the preventive effect of caffeic acid phenethyl ester (CAPE) on pancreatic damage induced by vancomycin (VCM) in rats. Rats were equally divided into three groups: group I (control), group II (only VCM-treated group) and group III (VCM + CAPE-treated groups). VCM was intraper...
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| Veröffentlicht in: | Toxicology and industrial health 2016-02, Vol.32 (2), p.306-312 |
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| creator | Koyu, Ahmet Gokalp, Osman Gumral, Nurhan Oktem, Faruk Karahan, Nermin Yilmaz, Nigar Saygin, Mustafa |
| description | This study investigates the preventive effect of caffeic acid phenethyl ester (CAPE) on pancreatic damage induced by vancomycin (VCM) in rats. Rats were equally divided into three groups: group I (control), group II (only VCM-treated group) and group III (VCM + CAPE-treated groups). VCM was intraperitoneally administered at a dose of 200 mg kg−1twice daily for 7 days. CAPE was administered orally at 10 µM mL−1 kg−1 dose once daily for 7 days. The first dose of CAPE administration was performed 24 h prior to VCM injection. Blood and pancreas tissue samples were removed and collected after the study. Serum alkaline phosphatase (ALP), amylase, γ-glutamyl transferase (GGT) and lipase activities were determined. Pancreas tissue samples were evaluated with the light microscope. Group II significantly increased serum ALP, amylase, GGT and lipase activities when compared with the control group. Group III significantly decreased serum ALP, amylase, GGT and lipase activities when compared with group II. In histopathological examination, it has been observed that there was a significant pancreatic damage in group II. CAPE exerted prominent structural protection against VCM-induced pancreatic damage and this effect was statistically significant. CAPE caused a marked reduction in the extent of pancreatic damage. We have concluded that it may play an important role in the VCM-induced pancreatic damage and reduce the pancreatic damage both at the biochemical and histopathological aspects. |
| doi_str_mv | 10.1177/0748233713501708 |
| format | Article |
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Rats were equally divided into three groups: group I (control), group II (only VCM-treated group) and group III (VCM + CAPE-treated groups). VCM was intraperitoneally administered at a dose of 200 mg kg−1twice daily for 7 days. CAPE was administered orally at 10 µM mL−1 kg−1 dose once daily for 7 days. The first dose of CAPE administration was performed 24 h prior to VCM injection. Blood and pancreas tissue samples were removed and collected after the study. Serum alkaline phosphatase (ALP), amylase, γ-glutamyl transferase (GGT) and lipase activities were determined. Pancreas tissue samples were evaluated with the light microscope. Group II significantly increased serum ALP, amylase, GGT and lipase activities when compared with the control group. Group III significantly decreased serum ALP, amylase, GGT and lipase activities when compared with group II. In histopathological examination, it has been observed that there was a significant pancreatic damage in group II. CAPE exerted prominent structural protection against VCM-induced pancreatic damage and this effect was statistically significant. CAPE caused a marked reduction in the extent of pancreatic damage. We have concluded that it may play an important role in the VCM-induced pancreatic damage and reduce the pancreatic damage both at the biochemical and histopathological aspects.</description><identifier>ISSN: 0748-2337</identifier><identifier>EISSN: 1477-0393</identifier><identifier>DOI: 10.1177/0748233713501708</identifier><identifier>PMID: 24097368</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Acute Disease ; Alkaline Phosphatase - blood ; Amylase ; Amylases - blood ; Animals ; Antioxidants - pharmacology ; Caffeic Acids - pharmacology ; Damage ; gamma-Glutamyltransferase - blood ; Lipase ; Lipase - blood ; Male ; Pancreas ; Pancreas - drug effects ; Pancreas - pathology ; Pancreatitis - chemically induced ; Pancreatitis - drug therapy ; Phenylethyl Alcohol - analogs & derivatives ; Phenylethyl Alcohol - pharmacology ; Rats ; Rats, Wistar ; Samples ; Serums ; Statistical methods ; Vancomycin - administration & dosage ; Vancomycin - adverse effects</subject><ispartof>Toxicology and industrial health, 2016-02, Vol.32 (2), p.306-312</ispartof><rights>The Author(s) 2013</rights><rights>The Author(s) 2013.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-2139e43b0eef32512a767a3ee027f8a0505507f79d55884ade09ca60da46c113</citedby><cites>FETCH-LOGICAL-c403t-2139e43b0eef32512a767a3ee027f8a0505507f79d55884ade09ca60da46c113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0748233713501708$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0748233713501708$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21824,27929,27930,43626,43627</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24097368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koyu, Ahmet</creatorcontrib><creatorcontrib>Gokalp, Osman</creatorcontrib><creatorcontrib>Gumral, Nurhan</creatorcontrib><creatorcontrib>Oktem, Faruk</creatorcontrib><creatorcontrib>Karahan, Nermin</creatorcontrib><creatorcontrib>Yilmaz, Nigar</creatorcontrib><creatorcontrib>Saygin, Mustafa</creatorcontrib><title>Impact of caffeic acid phenethyl ester treatment on vancomycin-induced pancreatic damage in rats</title><title>Toxicology and industrial health</title><addtitle>Toxicol Ind Health</addtitle><description>This study investigates the preventive effect of caffeic acid phenethyl ester (CAPE) on pancreatic damage induced by vancomycin (VCM) in rats. Rats were equally divided into three groups: group I (control), group II (only VCM-treated group) and group III (VCM + CAPE-treated groups). VCM was intraperitoneally administered at a dose of 200 mg kg−1twice daily for 7 days. CAPE was administered orally at 10 µM mL−1 kg−1 dose once daily for 7 days. The first dose of CAPE administration was performed 24 h prior to VCM injection. Blood and pancreas tissue samples were removed and collected after the study. Serum alkaline phosphatase (ALP), amylase, γ-glutamyl transferase (GGT) and lipase activities were determined. Pancreas tissue samples were evaluated with the light microscope. Group II significantly increased serum ALP, amylase, GGT and lipase activities when compared with the control group. Group III significantly decreased serum ALP, amylase, GGT and lipase activities when compared with group II. In histopathological examination, it has been observed that there was a significant pancreatic damage in group II. CAPE exerted prominent structural protection against VCM-induced pancreatic damage and this effect was statistically significant. CAPE caused a marked reduction in the extent of pancreatic damage. We have concluded that it may play an important role in the VCM-induced pancreatic damage and reduce the pancreatic damage both at the biochemical and histopathological aspects.</description><subject>Acute Disease</subject><subject>Alkaline Phosphatase - blood</subject><subject>Amylase</subject><subject>Amylases - blood</subject><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Caffeic Acids - pharmacology</subject><subject>Damage</subject><subject>gamma-Glutamyltransferase - blood</subject><subject>Lipase</subject><subject>Lipase - blood</subject><subject>Male</subject><subject>Pancreas</subject><subject>Pancreas - drug effects</subject><subject>Pancreas - pathology</subject><subject>Pancreatitis - chemically induced</subject><subject>Pancreatitis - drug therapy</subject><subject>Phenylethyl Alcohol - analogs & derivatives</subject><subject>Phenylethyl Alcohol - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Samples</subject><subject>Serums</subject><subject>Statistical methods</subject><subject>Vancomycin - administration & dosage</subject><subject>Vancomycin - adverse effects</subject><issn>0748-2337</issn><issn>1477-0393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1Lw0AQxRdRbP24e5I9eonOZrPZ7FGKH4WCl97jdDOxKc2m7iZC_3s3VD0IgqeBmd97DO8xdiXgVgit70BnRSqlFlKB0FAcsanItE5AGnnMpuM5Ge8TdhbCBgDyXKWnbJJmYLTMiyl7nbc7tD3vam6xrqmxHG1T8d2aHPXr_ZZT6Mnz3hP2LblIOv6Bznbt3jYuaVw1WIp8XI1I1FfY4hvxxnGPfbhgJzVuA11-zXO2fHxYzp6TxcvTfHa_SGwGsk9SIQ1lcgVEtUyVSFHnGiURpLouEBQoBbrWplKqKDKsCIzFHCrMciuEPGc3B9ud796H-HPZNsHSdouOuiGUQhuZmiyX6h9orowuDIwoHFDruxA81eXONy36fSmgHBsofzcQJddf7sOqpepH8B15BJIDEGJK5aYbvIu5_G34CfDZjQA</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Koyu, Ahmet</creator><creator>Gokalp, Osman</creator><creator>Gumral, Nurhan</creator><creator>Oktem, Faruk</creator><creator>Karahan, Nermin</creator><creator>Yilmaz, Nigar</creator><creator>Saygin, Mustafa</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope><scope>7TA</scope><scope>7TB</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>KR7</scope></search><sort><creationdate>20160201</creationdate><title>Impact of caffeic acid phenethyl ester treatment on vancomycin-induced pancreatic damage in rats</title><author>Koyu, Ahmet ; Gokalp, Osman ; Gumral, Nurhan ; Oktem, Faruk ; Karahan, Nermin ; Yilmaz, Nigar ; Saygin, Mustafa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-2139e43b0eef32512a767a3ee027f8a0505507f79d55884ade09ca60da46c113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acute Disease</topic><topic>Alkaline Phosphatase - blood</topic><topic>Amylase</topic><topic>Amylases - blood</topic><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Caffeic Acids - pharmacology</topic><topic>Damage</topic><topic>gamma-Glutamyltransferase - blood</topic><topic>Lipase</topic><topic>Lipase - blood</topic><topic>Male</topic><topic>Pancreas</topic><topic>Pancreas - drug effects</topic><topic>Pancreas - pathology</topic><topic>Pancreatitis - chemically induced</topic><topic>Pancreatitis - drug therapy</topic><topic>Phenylethyl Alcohol - analogs & derivatives</topic><topic>Phenylethyl Alcohol - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Samples</topic><topic>Serums</topic><topic>Statistical methods</topic><topic>Vancomycin - administration & dosage</topic><topic>Vancomycin - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koyu, Ahmet</creatorcontrib><creatorcontrib>Gokalp, Osman</creatorcontrib><creatorcontrib>Gumral, Nurhan</creatorcontrib><creatorcontrib>Oktem, Faruk</creatorcontrib><creatorcontrib>Karahan, Nermin</creatorcontrib><creatorcontrib>Yilmaz, Nigar</creatorcontrib><creatorcontrib>Saygin, Mustafa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>Toxicology and industrial health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koyu, Ahmet</au><au>Gokalp, Osman</au><au>Gumral, Nurhan</au><au>Oktem, Faruk</au><au>Karahan, Nermin</au><au>Yilmaz, Nigar</au><au>Saygin, Mustafa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of caffeic acid phenethyl ester treatment on vancomycin-induced pancreatic damage in rats</atitle><jtitle>Toxicology and industrial health</jtitle><addtitle>Toxicol Ind Health</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>32</volume><issue>2</issue><spage>306</spage><epage>312</epage><pages>306-312</pages><issn>0748-2337</issn><eissn>1477-0393</eissn><abstract>This study investigates the preventive effect of caffeic acid phenethyl ester (CAPE) on pancreatic damage induced by vancomycin (VCM) in rats. Rats were equally divided into three groups: group I (control), group II (only VCM-treated group) and group III (VCM + CAPE-treated groups). VCM was intraperitoneally administered at a dose of 200 mg kg−1twice daily for 7 days. CAPE was administered orally at 10 µM mL−1 kg−1 dose once daily for 7 days. The first dose of CAPE administration was performed 24 h prior to VCM injection. Blood and pancreas tissue samples were removed and collected after the study. Serum alkaline phosphatase (ALP), amylase, γ-glutamyl transferase (GGT) and lipase activities were determined. Pancreas tissue samples were evaluated with the light microscope. Group II significantly increased serum ALP, amylase, GGT and lipase activities when compared with the control group. Group III significantly decreased serum ALP, amylase, GGT and lipase activities when compared with group II. In histopathological examination, it has been observed that there was a significant pancreatic damage in group II. CAPE exerted prominent structural protection against VCM-induced pancreatic damage and this effect was statistically significant. CAPE caused a marked reduction in the extent of pancreatic damage. We have concluded that it may play an important role in the VCM-induced pancreatic damage and reduce the pancreatic damage both at the biochemical and histopathological aspects.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>24097368</pmid><doi>10.1177/0748233713501708</doi><tpages>7</tpages></addata></record> |
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| ispartof | Toxicology and industrial health, 2016-02, Vol.32 (2), p.306-312 |
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| subjects | Acute Disease Alkaline Phosphatase - blood Amylase Amylases - blood Animals Antioxidants - pharmacology Caffeic Acids - pharmacology Damage gamma-Glutamyltransferase - blood Lipase Lipase - blood Male Pancreas Pancreas - drug effects Pancreas - pathology Pancreatitis - chemically induced Pancreatitis - drug therapy Phenylethyl Alcohol - analogs & derivatives Phenylethyl Alcohol - pharmacology Rats Rats, Wistar Samples Serums Statistical methods Vancomycin - administration & dosage Vancomycin - adverse effects |
| title | Impact of caffeic acid phenethyl ester treatment on vancomycin-induced pancreatic damage in rats |
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