Silver–polysaccharide antimicrobial nanocomposite coating for methacrylic surfaces reduces Streptococcus mutans biofilm formation in vitro
[Display omitted] The aim of this study was to determine the in vitro microbiological performances of a lactose-modified chitosan (Chitlac) coating inside which silver nanoparticles were embedded (Chitlac-nAg) for BisGMA/TEGDMA methacrylic specimens. Different concentrations of nAg inside Chitlac co...
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| Veröffentlicht in: | Journal of dentistry 2015-12, Vol.43 (12), p.1483-1490 |
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| container_title | Journal of dentistry |
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| creator | Ionescu, A.C Brambilla, E Travan, A Marsich, E Donati, I Gobbi, P Turco, G Di Lenarda, R Cadenaro, M Paoletti, S Breschi, L |
| description | [Display omitted]
The aim of this study was to determine the in vitro microbiological performances of a lactose-modified chitosan (Chitlac) coating inside which silver nanoparticles were embedded (Chitlac-nAg) for BisGMA/TEGDMA methacrylic specimens.
Different concentrations of nAg inside Chitlac coating were tested (1mM, 2mM, 5mM). Specimen surface was analyzed by means of field-emission scanning electron microscopy (FEISEM) and energy-dispersive X-ray spectroscopy (EDS). A 48h monospecific Streptococcus mutans biofilm was developed over the specimen surfaces using a modified drip-flow bioreactor; adherent viable biomass was assessed by MTT test and biofilm was imaged by confocal laser-scanning microscopy (CLSM).
The presence of finely dispersed nanoparticles inside the Chitlac coating was confirmed by FEISEM and EDS analysis. All nanoparticles were embedded in the Chitlac coating layer. Chitlac-nAg coatings were able to significantly decrease biofilm formation depending on the nAg concentration, reaching a −80% viable biomass decrease when the 5mM nAg-Chitlac group was confronted to non-coated control specimens. CLSM analysis did not provide evidence of a contact-killing activity, however the antibacterial Chitlac-nAg coating was able to alter biofilm morphology preventing the development of mature biofilm structures.
The microbiological model applied in this study helped in assessing the antibacterial properties of a coating designed for methacrylate surfaces.
A microbiological model based on a bioreactor-grown biofilm is useful for preliminary in vitro tests of dental materials. In translational terms, an antibacterial nanocomposite coating based on Chitlac-nAg and designed to be applied to methacrylic surfaces may be a promising way to obtain dental materials able to actively prevent secondary caries. |
| doi_str_mv | 10.1016/j.jdent.2015.10.006 |
| format | Article |
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The aim of this study was to determine the in vitro microbiological performances of a lactose-modified chitosan (Chitlac) coating inside which silver nanoparticles were embedded (Chitlac-nAg) for BisGMA/TEGDMA methacrylic specimens.
Different concentrations of nAg inside Chitlac coating were tested (1mM, 2mM, 5mM). Specimen surface was analyzed by means of field-emission scanning electron microscopy (FEISEM) and energy-dispersive X-ray spectroscopy (EDS). A 48h monospecific Streptococcus mutans biofilm was developed over the specimen surfaces using a modified drip-flow bioreactor; adherent viable biomass was assessed by MTT test and biofilm was imaged by confocal laser-scanning microscopy (CLSM).
The presence of finely dispersed nanoparticles inside the Chitlac coating was confirmed by FEISEM and EDS analysis. All nanoparticles were embedded in the Chitlac coating layer. Chitlac-nAg coatings were able to significantly decrease biofilm formation depending on the nAg concentration, reaching a −80% viable biomass decrease when the 5mM nAg-Chitlac group was confronted to non-coated control specimens. CLSM analysis did not provide evidence of a contact-killing activity, however the antibacterial Chitlac-nAg coating was able to alter biofilm morphology preventing the development of mature biofilm structures.
The microbiological model applied in this study helped in assessing the antibacterial properties of a coating designed for methacrylate surfaces.
A microbiological model based on a bioreactor-grown biofilm is useful for preliminary in vitro tests of dental materials. In translational terms, an antibacterial nanocomposite coating based on Chitlac-nAg and designed to be applied to methacrylic surfaces may be a promising way to obtain dental materials able to actively prevent secondary caries.</description><identifier>ISSN: 0300-5712</identifier><identifier>EISSN: 1879-176X</identifier><identifier>DOI: 10.1016/j.jdent.2015.10.006</identifier><identifier>PMID: 26477347</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject><![CDATA[Acids ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - chemistry ; Antiinfectives and antibacterials ; Antimicrobial agents ; Bacteriology ; Biofilm ; Biofilms ; Biofilms - drug effects ; Biomass ; Biomedical materials ; Bioreactors ; Cells, Cultured ; Coated Materials, Biocompatible - chemistry ; Coating ; Dental Caries - prevention & control ; Dental Materials ; Dentistry ; Humans ; In vitro testing ; Lactose ; Metal Nanoparticles - chemistry ; Methacrylates - administration & dosage ; Methacrylates - chemistry ; Microbial Sensitivity Tests ; Microbial Viability ; Microorganisms ; Nanocomposite ; Nanocomposites - administration & dosage ; Nanocomposites - chemistry ; Nanoparticles ; Polysaccharides - administration & dosage ; Polysaccharides - chemistry ; Silver - administration & dosage ; Silver - chemistry ; Silver nanoparticles ; Streptococcus mutans ; Streptococcus mutans - drug effects ; Streptococcus mutans - physiology ; Studies ; Surface chemistry ; Surface Properties]]></subject><ispartof>Journal of dentistry, 2015-12, Vol.43 (12), p.1483-1490</ispartof><rights>Elsevier Ltd</rights><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Dec 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c574t-f3da0aaa5192edfa712d23589b21cc3ba3b7daba495bd2913bd50d31572a90f3</citedby><cites>FETCH-LOGICAL-c574t-f3da0aaa5192edfa712d23589b21cc3ba3b7daba495bd2913bd50d31572a90f3</cites><orcidid>0000-0001-7621-226X ; 0000-0003-4705-0833</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030057121530052X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26477347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ionescu, A.C</creatorcontrib><creatorcontrib>Brambilla, E</creatorcontrib><creatorcontrib>Travan, A</creatorcontrib><creatorcontrib>Marsich, E</creatorcontrib><creatorcontrib>Donati, I</creatorcontrib><creatorcontrib>Gobbi, P</creatorcontrib><creatorcontrib>Turco, G</creatorcontrib><creatorcontrib>Di Lenarda, R</creatorcontrib><creatorcontrib>Cadenaro, M</creatorcontrib><creatorcontrib>Paoletti, S</creatorcontrib><creatorcontrib>Breschi, L</creatorcontrib><title>Silver–polysaccharide antimicrobial nanocomposite coating for methacrylic surfaces reduces Streptococcus mutans biofilm formation in vitro</title><title>Journal of dentistry</title><addtitle>J Dent</addtitle><description>[Display omitted]
The aim of this study was to determine the in vitro microbiological performances of a lactose-modified chitosan (Chitlac) coating inside which silver nanoparticles were embedded (Chitlac-nAg) for BisGMA/TEGDMA methacrylic specimens.
Different concentrations of nAg inside Chitlac coating were tested (1mM, 2mM, 5mM). Specimen surface was analyzed by means of field-emission scanning electron microscopy (FEISEM) and energy-dispersive X-ray spectroscopy (EDS). A 48h monospecific Streptococcus mutans biofilm was developed over the specimen surfaces using a modified drip-flow bioreactor; adherent viable biomass was assessed by MTT test and biofilm was imaged by confocal laser-scanning microscopy (CLSM).
The presence of finely dispersed nanoparticles inside the Chitlac coating was confirmed by FEISEM and EDS analysis. All nanoparticles were embedded in the Chitlac coating layer. Chitlac-nAg coatings were able to significantly decrease biofilm formation depending on the nAg concentration, reaching a −80% viable biomass decrease when the 5mM nAg-Chitlac group was confronted to non-coated control specimens. CLSM analysis did not provide evidence of a contact-killing activity, however the antibacterial Chitlac-nAg coating was able to alter biofilm morphology preventing the development of mature biofilm structures.
The microbiological model applied in this study helped in assessing the antibacterial properties of a coating designed for methacrylate surfaces.
A microbiological model based on a bioreactor-grown biofilm is useful for preliminary in vitro tests of dental materials. In translational terms, an antibacterial nanocomposite coating based on Chitlac-nAg and designed to be applied to methacrylic surfaces may be a promising way to obtain dental materials able to actively prevent secondary caries.</description><subject>Acids</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial agents</subject><subject>Bacteriology</subject><subject>Biofilm</subject><subject>Biofilms</subject><subject>Biofilms - drug effects</subject><subject>Biomass</subject><subject>Biomedical materials</subject><subject>Bioreactors</subject><subject>Cells, Cultured</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Coating</subject><subject>Dental Caries - prevention & control</subject><subject>Dental Materials</subject><subject>Dentistry</subject><subject>Humans</subject><subject>In vitro testing</subject><subject>Lactose</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Methacrylates - administration & dosage</subject><subject>Methacrylates - chemistry</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbial Viability</subject><subject>Microorganisms</subject><subject>Nanocomposite</subject><subject>Nanocomposites - administration & dosage</subject><subject>Nanocomposites - chemistry</subject><subject>Nanoparticles</subject><subject>Polysaccharides - administration & dosage</subject><subject>Polysaccharides - chemistry</subject><subject>Silver - administration & dosage</subject><subject>Silver - chemistry</subject><subject>Silver nanoparticles</subject><subject>Streptococcus mutans</subject><subject>Streptococcus mutans - drug effects</subject><subject>Streptococcus mutans - physiology</subject><subject>Studies</subject><subject>Surface chemistry</subject><subject>Surface Properties</subject><issn>0300-5712</issn><issn>1879-176X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks-KFDEQxhtR3HH1CQRp8OJlxvzpdCYHBVnWP7DgYfawt1CdVLsZu5MxSQ_MzQfwtm_ok5h2VoW9uKcKxe_7QlV9VfWckhUltH29XW0t-rxihIrSWRHSPqgWdC3Vksr26mG1IJyQpZCUnVRPUtoSQhrC1OPqhLWNlLyRi-rHxg17jD-_3-zCcEhgzDVEZ7EGn93oTAydg6H24IMJ4y4kl7E2AbLzX-o-xHrEfA0mHgZn6jTFHgymOqKd5rrJEXe5KI2ZUj1OGXyqOxd6N4yzeiw-wdfO13uXY3haPephSPjstp5Wl-_PL88-Li8-f_h09u5iaYRs8rLnFggACKoY2h7KgJZxsVYdo8bwDngnLXTQKNFZpijvrCCWUyEZKNLz0-rV0XYXw7cJU9ajSwaHATyGKWkqFWfrtSTsHuhaME4ob--BNkqpYksL-vIOug1T9GXkmWqFamWrCsWPVDlCShF7vYtuhHjQlOg5AXqrfydAzwmYmyUBRfXi1nvqRrR_NX9OXoA3RwDLhvcOo07GoTdoXUSTtQ3uPx-8vaM3g_POwPAVD5j-TaIT00Rv5hDOGaRifrAr_gs03dxC</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Ionescu, A.C</creator><creator>Brambilla, E</creator><creator>Travan, A</creator><creator>Marsich, E</creator><creator>Donati, I</creator><creator>Gobbi, P</creator><creator>Turco, G</creator><creator>Di Lenarda, R</creator><creator>Cadenaro, M</creator><creator>Paoletti, S</creator><creator>Breschi, L</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SE</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8G</scope><scope>JG9</scope><scope>K9.</scope><scope>7X8</scope><scope>7QL</scope><scope>7T7</scope><scope>C1K</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0001-7621-226X</orcidid><orcidid>https://orcid.org/0000-0003-4705-0833</orcidid></search><sort><creationdate>20151201</creationdate><title>Silver–polysaccharide antimicrobial nanocomposite coating for methacrylic surfaces reduces Streptococcus mutans biofilm formation in vitro</title><author>Ionescu, A.C ; 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The aim of this study was to determine the in vitro microbiological performances of a lactose-modified chitosan (Chitlac) coating inside which silver nanoparticles were embedded (Chitlac-nAg) for BisGMA/TEGDMA methacrylic specimens.
Different concentrations of nAg inside Chitlac coating were tested (1mM, 2mM, 5mM). Specimen surface was analyzed by means of field-emission scanning electron microscopy (FEISEM) and energy-dispersive X-ray spectroscopy (EDS). A 48h monospecific Streptococcus mutans biofilm was developed over the specimen surfaces using a modified drip-flow bioreactor; adherent viable biomass was assessed by MTT test and biofilm was imaged by confocal laser-scanning microscopy (CLSM).
The presence of finely dispersed nanoparticles inside the Chitlac coating was confirmed by FEISEM and EDS analysis. All nanoparticles were embedded in the Chitlac coating layer. Chitlac-nAg coatings were able to significantly decrease biofilm formation depending on the nAg concentration, reaching a −80% viable biomass decrease when the 5mM nAg-Chitlac group was confronted to non-coated control specimens. CLSM analysis did not provide evidence of a contact-killing activity, however the antibacterial Chitlac-nAg coating was able to alter biofilm morphology preventing the development of mature biofilm structures.
The microbiological model applied in this study helped in assessing the antibacterial properties of a coating designed for methacrylate surfaces.
A microbiological model based on a bioreactor-grown biofilm is useful for preliminary in vitro tests of dental materials. In translational terms, an antibacterial nanocomposite coating based on Chitlac-nAg and designed to be applied to methacrylic surfaces may be a promising way to obtain dental materials able to actively prevent secondary caries.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26477347</pmid><doi>10.1016/j.jdent.2015.10.006</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7621-226X</orcidid><orcidid>https://orcid.org/0000-0003-4705-0833</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of dentistry, 2015-12, Vol.43 (12), p.1483-1490 |
| issn | 0300-5712 1879-176X |
| language | eng |
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| subjects | Acids Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - chemistry Antiinfectives and antibacterials Antimicrobial agents Bacteriology Biofilm Biofilms Biofilms - drug effects Biomass Biomedical materials Bioreactors Cells, Cultured Coated Materials, Biocompatible - chemistry Coating Dental Caries - prevention & control Dental Materials Dentistry Humans In vitro testing Lactose Metal Nanoparticles - chemistry Methacrylates - administration & dosage Methacrylates - chemistry Microbial Sensitivity Tests Microbial Viability Microorganisms Nanocomposite Nanocomposites - administration & dosage Nanocomposites - chemistry Nanoparticles Polysaccharides - administration & dosage Polysaccharides - chemistry Silver - administration & dosage Silver - chemistry Silver nanoparticles Streptococcus mutans Streptococcus mutans - drug effects Streptococcus mutans - physiology Studies Surface chemistry Surface Properties |
| title | Silver–polysaccharide antimicrobial nanocomposite coating for methacrylic surfaces reduces Streptococcus mutans biofilm formation in vitro |
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