A new hydrothermal refluxing route to strong fluorescent carbon dots and its application as fluorescent imaging agent
Due to their unique optical and biochemical properties, the water-soluble fluorescent carbon dots (CDs) have attracted a lot of attention recently. Here, strong fluorescent carbon dots with excellent quality have been synthesized by the hydrothermal refluxing method using lactose as carbon source an...
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| Veröffentlicht in: | Talanta (Oxford) 2013-12, Vol.117, p.196-202 |
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| creator | Zhang, Ye-Yun Wu, Ming Wang, Yan-Qin He, Xi-Wen Li, Wen-You Feng, Xi-Zeng |
| description | Due to their unique optical and biochemical properties, the water-soluble fluorescent carbon dots (CDs) have attracted a lot of attention recently. Here, strong fluorescent carbon dots with excellent quality have been synthesized by the hydrothermal refluxing method using lactose as carbon source and tris(hydroxymethyl) aminomethane (i.e. Tris) as surface passivation reagent. This facile approach was simple, efficient, economical, green without pollution, and allows large-scale production of CDs without any post-treatment. TEM measurements showed that the resulting particles exhibited an average diameter of 1.5nm. The obtained CDs possess small particle sizes, good stability in a wide range of pH values (pH 3.5–9.5), high tolerance of salt concentration, strong resistibility to photobleaching, and a fluorescent quantum yield up to 12.5%. The CDs were applied to optical bioimaging of HeLa cells, showing low cytotoxicity and excellent biocompatibility.
Strong fluorescent carbon dots with excellent quality were synthesized by a single-step hydrothermal refluxing method using lactose and tris(hydroxymethyl) aminomethane. [Display omitted]
•Strong fluorescent carbon dots with excellent quality have been synthesized by hydrothermally refluxing lactose and tris(hydroxymethyl) aminomethane (i.e. Tris).•This facile approach was simple, mild, green and allows large-scale production of CDs without any post-treatment.•The CDs were applied to optical bioimaging of HeLa cells, showing low cytotoxicity and excellent biocompatibility. |
| doi_str_mv | 10.1016/j.talanta.2013.09.003 |
| format | Article |
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Strong fluorescent carbon dots with excellent quality were synthesized by a single-step hydrothermal refluxing method using lactose and tris(hydroxymethyl) aminomethane. [Display omitted]
•Strong fluorescent carbon dots with excellent quality have been synthesized by hydrothermally refluxing lactose and tris(hydroxymethyl) aminomethane (i.e. Tris).•This facile approach was simple, mild, green and allows large-scale production of CDs without any post-treatment.•The CDs were applied to optical bioimaging of HeLa cells, showing low cytotoxicity and excellent biocompatibility.</description><identifier>ISSN: 0039-9140</identifier><identifier>EISSN: 1873-3573</identifier><identifier>DOI: 10.1016/j.talanta.2013.09.003</identifier><identifier>PMID: 24209330</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Biochemistry ; Carbon ; Carbon - chemistry ; Carbon dots ; Cell Survival - drug effects ; Fluorescence ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; Hydrothermal refluxing ; Imaging ; Lactose ; Lactose - chemistry ; Microscopy, Electron, Transmission ; Molecular Imaging - methods ; Molecular Probes - chemical synthesis ; Molecular Probes - pharmacology ; Molecular Probes - ultrastructure ; Nanoparticles ; Particle Size ; Quantum Dots - chemistry ; Quantum Dots - toxicity ; Quantum Dots - ultrastructure ; Reagents ; Refluxing ; Tolerances ; Tris ; Tromethamine - chemistry</subject><ispartof>Talanta (Oxford), 2013-12, Vol.117, p.196-202</ispartof><rights>2013 Elsevier B.V.</rights><rights>2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-4c8db09789dad469a7af451bc5a26c8654935f6832b4516357cceb221d0a0f843</citedby><cites>FETCH-LOGICAL-c431t-4c8db09789dad469a7af451bc5a26c8654935f6832b4516357cceb221d0a0f843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0039914013007315$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24209330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Ye-Yun</creatorcontrib><creatorcontrib>Wu, Ming</creatorcontrib><creatorcontrib>Wang, Yan-Qin</creatorcontrib><creatorcontrib>He, Xi-Wen</creatorcontrib><creatorcontrib>Li, Wen-You</creatorcontrib><creatorcontrib>Feng, Xi-Zeng</creatorcontrib><title>A new hydrothermal refluxing route to strong fluorescent carbon dots and its application as fluorescent imaging agent</title><title>Talanta (Oxford)</title><addtitle>Talanta</addtitle><description>Due to their unique optical and biochemical properties, the water-soluble fluorescent carbon dots (CDs) have attracted a lot of attention recently. Here, strong fluorescent carbon dots with excellent quality have been synthesized by the hydrothermal refluxing method using lactose as carbon source and tris(hydroxymethyl) aminomethane (i.e. Tris) as surface passivation reagent. This facile approach was simple, efficient, economical, green without pollution, and allows large-scale production of CDs without any post-treatment. TEM measurements showed that the resulting particles exhibited an average diameter of 1.5nm. The obtained CDs possess small particle sizes, good stability in a wide range of pH values (pH 3.5–9.5), high tolerance of salt concentration, strong resistibility to photobleaching, and a fluorescent quantum yield up to 12.5%. The CDs were applied to optical bioimaging of HeLa cells, showing low cytotoxicity and excellent biocompatibility.
Strong fluorescent carbon dots with excellent quality were synthesized by a single-step hydrothermal refluxing method using lactose and tris(hydroxymethyl) aminomethane. [Display omitted]
•Strong fluorescent carbon dots with excellent quality have been synthesized by hydrothermally refluxing lactose and tris(hydroxymethyl) aminomethane (i.e. Tris).•This facile approach was simple, mild, green and allows large-scale production of CDs without any post-treatment.•The CDs were applied to optical bioimaging of HeLa cells, showing low cytotoxicity and excellent biocompatibility.</description><subject>Biochemistry</subject><subject>Carbon</subject><subject>Carbon - chemistry</subject><subject>Carbon dots</subject><subject>Cell Survival - drug effects</subject><subject>Fluorescence</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hydrothermal refluxing</subject><subject>Imaging</subject><subject>Lactose</subject><subject>Lactose - chemistry</subject><subject>Microscopy, Electron, Transmission</subject><subject>Molecular Imaging - methods</subject><subject>Molecular Probes - chemical synthesis</subject><subject>Molecular Probes - pharmacology</subject><subject>Molecular Probes - ultrastructure</subject><subject>Nanoparticles</subject><subject>Particle Size</subject><subject>Quantum Dots - chemistry</subject><subject>Quantum Dots - toxicity</subject><subject>Quantum Dots - ultrastructure</subject><subject>Reagents</subject><subject>Refluxing</subject><subject>Tolerances</subject><subject>Tris</subject><subject>Tromethamine - chemistry</subject><issn>0039-9140</issn><issn>1873-3573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu3CAUhlHVqpmkfYRWLLuxc7gYw6qKoraJFKmbdo0w4Akjj5kCzuXty2gmkbKa1dE5fOfC_yP0hUBLgIjLTVvMZOZiWgqEtaBaAPYOrYjsWcO6nr1Hq1pRjSIcztB5zhsAoAzYR3RGOQXFGKzQcoVn_4jvn12K5d6nrZlw8uO0PIV5jVNciscl4lxSrHmtx-Sz9XPB1qQhztjFkrGZHQ77uNtNwZoS6oPJb_CwNev9SLOu2Sf0YTRT9p-P8QL9_fnjz_VNc_f71-311V1jOSOl4Va6AVQvlTOOC2V6M_KODLYzVFgpOq5YNwrJ6FDLov7aWj9QShwYGCVnF-jbYe4uxX-Lz0VvQz1nqsL5uGRNesWoFFyJ02hd0AvaSXUa5Z0kUlAmK9odUJtizlVYvUtVifSsCei9j3qjjz7qvY8alK6u1b6vxxXLsPXutevFuAp8PwC-yvcQfNLZBj9b70LytmgXw4kV_wFFgLIb</recordid><startdate>20131215</startdate><enddate>20131215</enddate><creator>Zhang, Ye-Yun</creator><creator>Wu, Ming</creator><creator>Wang, Yan-Qin</creator><creator>He, Xi-Wen</creator><creator>Li, Wen-You</creator><creator>Feng, Xi-Zeng</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QH</scope><scope>7TV</scope><scope>7UA</scope><scope>C1K</scope><scope>7QQ</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20131215</creationdate><title>A new hydrothermal refluxing route to strong fluorescent carbon dots and its application as fluorescent imaging agent</title><author>Zhang, Ye-Yun ; Wu, Ming ; Wang, Yan-Qin ; He, Xi-Wen ; Li, Wen-You ; Feng, Xi-Zeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-4c8db09789dad469a7af451bc5a26c8654935f6832b4516357cceb221d0a0f843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Biochemistry</topic><topic>Carbon</topic><topic>Carbon - chemistry</topic><topic>Carbon dots</topic><topic>Cell Survival - drug effects</topic><topic>Fluorescence</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hydrothermal refluxing</topic><topic>Imaging</topic><topic>Lactose</topic><topic>Lactose - chemistry</topic><topic>Microscopy, Electron, Transmission</topic><topic>Molecular Imaging - methods</topic><topic>Molecular Probes - chemical synthesis</topic><topic>Molecular Probes - pharmacology</topic><topic>Molecular Probes - ultrastructure</topic><topic>Nanoparticles</topic><topic>Particle Size</topic><topic>Quantum Dots - chemistry</topic><topic>Quantum Dots - toxicity</topic><topic>Quantum Dots - ultrastructure</topic><topic>Reagents</topic><topic>Refluxing</topic><topic>Tolerances</topic><topic>Tris</topic><topic>Tromethamine - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Ye-Yun</creatorcontrib><creatorcontrib>Wu, Ming</creatorcontrib><creatorcontrib>Wang, Yan-Qin</creatorcontrib><creatorcontrib>He, Xi-Wen</creatorcontrib><creatorcontrib>Li, Wen-You</creatorcontrib><creatorcontrib>Feng, Xi-Zeng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Aqualine</collection><collection>Pollution Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Ceramic Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Talanta (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Ye-Yun</au><au>Wu, Ming</au><au>Wang, Yan-Qin</au><au>He, Xi-Wen</au><au>Li, Wen-You</au><au>Feng, Xi-Zeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new hydrothermal refluxing route to strong fluorescent carbon dots and its application as fluorescent imaging agent</atitle><jtitle>Talanta (Oxford)</jtitle><addtitle>Talanta</addtitle><date>2013-12-15</date><risdate>2013</risdate><volume>117</volume><spage>196</spage><epage>202</epage><pages>196-202</pages><issn>0039-9140</issn><eissn>1873-3573</eissn><abstract>Due to their unique optical and biochemical properties, the water-soluble fluorescent carbon dots (CDs) have attracted a lot of attention recently. Here, strong fluorescent carbon dots with excellent quality have been synthesized by the hydrothermal refluxing method using lactose as carbon source and tris(hydroxymethyl) aminomethane (i.e. Tris) as surface passivation reagent. This facile approach was simple, efficient, economical, green without pollution, and allows large-scale production of CDs without any post-treatment. TEM measurements showed that the resulting particles exhibited an average diameter of 1.5nm. The obtained CDs possess small particle sizes, good stability in a wide range of pH values (pH 3.5–9.5), high tolerance of salt concentration, strong resistibility to photobleaching, and a fluorescent quantum yield up to 12.5%. The CDs were applied to optical bioimaging of HeLa cells, showing low cytotoxicity and excellent biocompatibility.
Strong fluorescent carbon dots with excellent quality were synthesized by a single-step hydrothermal refluxing method using lactose and tris(hydroxymethyl) aminomethane. [Display omitted]
•Strong fluorescent carbon dots with excellent quality have been synthesized by hydrothermally refluxing lactose and tris(hydroxymethyl) aminomethane (i.e. Tris).•This facile approach was simple, mild, green and allows large-scale production of CDs without any post-treatment.•The CDs were applied to optical bioimaging of HeLa cells, showing low cytotoxicity and excellent biocompatibility.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24209330</pmid><doi>10.1016/j.talanta.2013.09.003</doi><tpages>7</tpages></addata></record> |
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| subjects | Biochemistry Carbon Carbon - chemistry Carbon dots Cell Survival - drug effects Fluorescence HeLa Cells Humans Hydrogen-Ion Concentration Hydrothermal refluxing Imaging Lactose Lactose - chemistry Microscopy, Electron, Transmission Molecular Imaging - methods Molecular Probes - chemical synthesis Molecular Probes - pharmacology Molecular Probes - ultrastructure Nanoparticles Particle Size Quantum Dots - chemistry Quantum Dots - toxicity Quantum Dots - ultrastructure Reagents Refluxing Tolerances Tris Tromethamine - chemistry |
| title | A new hydrothermal refluxing route to strong fluorescent carbon dots and its application as fluorescent imaging agent |
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