Targeted intracellular protein delivery based on hyaluronic acid–green tea catechin nanogels

[Display omitted] A novel ternary nanogel based on the self-assembly of hyaluronic acid-epigallocatechin gallate conjugates (HA–EGCG), linear polyethylenimine (PEI) and Granzyme B (GzmB) in an aqueous environment was developed for the targeted intracellular delivery of GzmB into cancer cells. Lysozy...

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Veröffentlicht in:	Acta biomaterialia 2016-03, Vol.33, p.142-152
Hauptverfasser:	Liang, Kun, Ng, Shengyong, Lee, Fan, Lim, Jaehong, Chung, Joo Eun, Lee, Su Seong, Kurisawa, Motoichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Cancer therapy Catechin - analogs & derivatives Catechin - chemical synthesis Catechin - chemistry Catechins Cell Survival - drug effects Chickens Dimerization Drug Delivery Systems - methods Dynamic Light Scattering Epigallocatechin gallate Flow Cytometry Granzymes - metabolism HCT116 Cells Hep G2 Cells Humans Hyaluronan Receptors - metabolism Hyaluronic acid Hyaluronic Acid - chemical synthesis Hyaluronic Acid - chemistry Hydroxyapatite Intracellular Space - metabolism Muramidase - metabolism Nanogels Nanostructure Polyetherimides Polyethylene Glycols - chemistry Polyethyleneimine - chemistry Protein delivery Proteins Self assembly Spectrometry, Fluorescence Tea - chemistry Therapy
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