Syntheses, Structures, and Antimicrobial Activity of New Remarkably Light-Stable and Water-Soluble Tris(pyrazolyl)methanesulfonate Silver(I) Derivatives of N-Methyl-1,3,5-triaza-7-phosphaadamantane Salt - [mPTA]BF sub(4)
Two newsilver(I) complexes of formula [Ag(mPTA) sub(4)](Tpms) sub(4)(BF sub(4)) (1) and [Ag(Tpms)(mPTA)] (BF sub(4)) (2) (mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane cation, Tpms = tris(pyrazol-1 yl)methanesulfonate anion) have been synthesized and fully characterized by elemental analyses, sup...
Gespeichert in:
| Veröffentlicht in: | Inorganic chemistry 2015-01, Vol.54 (2), p.434-440 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 440 |
|---|---|
| container_issue | 2 |
| container_start_page | 434 |
| container_title | Inorganic chemistry |
| container_volume | 54 |
| creator | Smolenski, Piotr Pettinari, Claudio Marchetti, Fabio Silva, M Fatima C Guedesda Lupidi, Giulio Patzmay, Gretta Veronica Badillo Petrelli, Dezemona Vitali, Luca A Pombeiro, Armando J L |
| description | Two newsilver(I) complexes of formula [Ag(mPTA) sub(4)](Tpms) sub(4)(BF sub(4)) (1) and [Ag(Tpms)(mPTA)] (BF sub(4)) (2) (mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane cation, Tpms = tris(pyrazol-1 yl)methanesulfonate anion) have been synthesized and fully characterized by elemental analyses, super(1)H and super(31)P{ super(1)H} NMR, ESI-MS, and IR spectroscopic techniques. The single-crystal X-ray diffraction study of 1 discloses a noncoordinated nature of the Tpms species, existing as counterions around the highly charged metal center [Ag(mPTA)] super(5+), 1 being the first reported coordination compound bearing a Kappa super(0)-Tpms. 1 features high solubility and stability in water (S sub(25[degrees]C) = 30 mg times mL super(-1)). The two complexes interact with calf thymus DNA via intercalation mode, binding to the BSA with decrease of its tryptophan fluorescence with a static quenching mechanism. The two new silver complexes exhibit significant antibacterial and antifungal activities screened in vitro against the standard strains of Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans. |
| doi_str_mv | 10.1021/ic501855k |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_1793267777</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1773834704</sourcerecordid><originalsourceid>FETCH-LOGICAL-p667-1d38dad814911bfad87dba014101c530661911d5b9131feeafb379426595f00c3</originalsourceid><addsrcrecordid>eNqNTslOwzAQzQEk1gN_4GMr1eCpE6c5lqWAVBaRShwQQpPEIQZnwXaKwrfyMZjlA5jLvJl5ywTBAbBDYFM4UnnEYBZFrxvBNmNTRkGIZCvYsfaFMZbwUGwHn-nQuEpaaSckdabPXW--MTYFmTdO1So3baZQk3nu1Fq5gbQluZbv5E7WaF4x0wNZqufK0dT5Qf4o79FJQ9NW99-blVF21A0GP1o96HEtXYWNtL0u28YTSar0WprR5ZicSqPW6HOk_YmhV547aAoTPomoMwo_kMa0q1rbVYgF1tg470VS1I5Q8lDfruaPxwti-2wUjveCzRK1lft_fTdYLc5WJxd0eXN-eTJf0k6ImELBZwUWMwgTgKz0KC4yZBACgzziTAjwhyLKEuBQSollxuMknIooiUrGcr4bjH5tO9O-9dK6p1rZXGrtP2t7-wRxwqci9vUPasxnPIxZyL8AOW-Omw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1773834704</pqid></control><display><type>article</type><title>Syntheses, Structures, and Antimicrobial Activity of New Remarkably Light-Stable and Water-Soluble Tris(pyrazolyl)methanesulfonate Silver(I) Derivatives of N-Methyl-1,3,5-triaza-7-phosphaadamantane Salt - [mPTA]BF sub(4)</title><source>ACS Publications</source><creator>Smolenski, Piotr ; Pettinari, Claudio ; Marchetti, Fabio ; Silva, M Fatima C Guedesda ; Lupidi, Giulio ; Patzmay, Gretta Veronica Badillo ; Petrelli, Dezemona ; Vitali, Luca A ; Pombeiro, Armando J L</creator><creatorcontrib>Smolenski, Piotr ; Pettinari, Claudio ; Marchetti, Fabio ; Silva, M Fatima C Guedesda ; Lupidi, Giulio ; Patzmay, Gretta Veronica Badillo ; Petrelli, Dezemona ; Vitali, Luca A ; Pombeiro, Armando J L</creatorcontrib><description>Two newsilver(I) complexes of formula [Ag(mPTA) sub(4)](Tpms) sub(4)(BF sub(4)) (1) and [Ag(Tpms)(mPTA)] (BF sub(4)) (2) (mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane cation, Tpms = tris(pyrazol-1 yl)methanesulfonate anion) have been synthesized and fully characterized by elemental analyses, super(1)H and super(31)P{ super(1)H} NMR, ESI-MS, and IR spectroscopic techniques. The single-crystal X-ray diffraction study of 1 discloses a noncoordinated nature of the Tpms species, existing as counterions around the highly charged metal center [Ag(mPTA)] super(5+), 1 being the first reported coordination compound bearing a Kappa super(0)-Tpms. 1 features high solubility and stability in water (S sub(25[degrees]C) = 30 mg times mL super(-1)). The two complexes interact with calf thymus DNA via intercalation mode, binding to the BSA with decrease of its tryptophan fluorescence with a static quenching mechanism. The two new silver complexes exhibit significant antibacterial and antifungal activities screened in vitro against the standard strains of Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans.</description><identifier>ISSN: 0020-1669</identifier><identifier>DOI: 10.1021/ic501855k</identifier><language>eng</language><subject>Antiinfectives and antibacterials ; Candida albicans ; Cations ; Coordination compounds ; Derivatives ; Enterococcus faecalis ; Escherichia coli ; Pseudomonas aeruginosa ; Silver ; Staphylococcus aureus ; Tryptophan</subject><ispartof>Inorganic chemistry, 2015-01, Vol.54 (2), p.434-440</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Smolenski, Piotr</creatorcontrib><creatorcontrib>Pettinari, Claudio</creatorcontrib><creatorcontrib>Marchetti, Fabio</creatorcontrib><creatorcontrib>Silva, M Fatima C Guedesda</creatorcontrib><creatorcontrib>Lupidi, Giulio</creatorcontrib><creatorcontrib>Patzmay, Gretta Veronica Badillo</creatorcontrib><creatorcontrib>Petrelli, Dezemona</creatorcontrib><creatorcontrib>Vitali, Luca A</creatorcontrib><creatorcontrib>Pombeiro, Armando J L</creatorcontrib><title>Syntheses, Structures, and Antimicrobial Activity of New Remarkably Light-Stable and Water-Soluble Tris(pyrazolyl)methanesulfonate Silver(I) Derivatives of N-Methyl-1,3,5-triaza-7-phosphaadamantane Salt - [mPTA]BF sub(4)</title><title>Inorganic chemistry</title><description>Two newsilver(I) complexes of formula [Ag(mPTA) sub(4)](Tpms) sub(4)(BF sub(4)) (1) and [Ag(Tpms)(mPTA)] (BF sub(4)) (2) (mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane cation, Tpms = tris(pyrazol-1 yl)methanesulfonate anion) have been synthesized and fully characterized by elemental analyses, super(1)H and super(31)P{ super(1)H} NMR, ESI-MS, and IR spectroscopic techniques. The single-crystal X-ray diffraction study of 1 discloses a noncoordinated nature of the Tpms species, existing as counterions around the highly charged metal center [Ag(mPTA)] super(5+), 1 being the first reported coordination compound bearing a Kappa super(0)-Tpms. 1 features high solubility and stability in water (S sub(25[degrees]C) = 30 mg times mL super(-1)). The two complexes interact with calf thymus DNA via intercalation mode, binding to the BSA with decrease of its tryptophan fluorescence with a static quenching mechanism. The two new silver complexes exhibit significant antibacterial and antifungal activities screened in vitro against the standard strains of Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans.</description><subject>Antiinfectives and antibacterials</subject><subject>Candida albicans</subject><subject>Cations</subject><subject>Coordination compounds</subject><subject>Derivatives</subject><subject>Enterococcus faecalis</subject><subject>Escherichia coli</subject><subject>Pseudomonas aeruginosa</subject><subject>Silver</subject><subject>Staphylococcus aureus</subject><subject>Tryptophan</subject><issn>0020-1669</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNTslOwzAQzQEk1gN_4GMr1eCpE6c5lqWAVBaRShwQQpPEIQZnwXaKwrfyMZjlA5jLvJl5ywTBAbBDYFM4UnnEYBZFrxvBNmNTRkGIZCvYsfaFMZbwUGwHn-nQuEpaaSckdabPXW--MTYFmTdO1So3baZQk3nu1Fq5gbQluZbv5E7WaF4x0wNZqufK0dT5Qf4o79FJQ9NW99-blVF21A0GP1o96HEtXYWNtL0u28YTSar0WprR5ZicSqPW6HOk_YmhV547aAoTPomoMwo_kMa0q1rbVYgF1tg470VS1I5Q8lDfruaPxwti-2wUjveCzRK1lft_fTdYLc5WJxd0eXN-eTJf0k6ImELBZwUWMwgTgKz0KC4yZBACgzziTAjwhyLKEuBQSollxuMknIooiUrGcr4bjH5tO9O-9dK6p1rZXGrtP2t7-wRxwqci9vUPasxnPIxZyL8AOW-Omw</recordid><startdate>20150119</startdate><enddate>20150119</enddate><creator>Smolenski, Piotr</creator><creator>Pettinari, Claudio</creator><creator>Marchetti, Fabio</creator><creator>Silva, M Fatima C Guedesda</creator><creator>Lupidi, Giulio</creator><creator>Patzmay, Gretta Veronica Badillo</creator><creator>Petrelli, Dezemona</creator><creator>Vitali, Luca A</creator><creator>Pombeiro, Armando J L</creator><scope>7QL</scope><scope>C1K</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20150119</creationdate><title>Syntheses, Structures, and Antimicrobial Activity of New Remarkably Light-Stable and Water-Soluble Tris(pyrazolyl)methanesulfonate Silver(I) Derivatives of N-Methyl-1,3,5-triaza-7-phosphaadamantane Salt - [mPTA]BF sub(4)</title><author>Smolenski, Piotr ; Pettinari, Claudio ; Marchetti, Fabio ; Silva, M Fatima C Guedesda ; Lupidi, Giulio ; Patzmay, Gretta Veronica Badillo ; Petrelli, Dezemona ; Vitali, Luca A ; Pombeiro, Armando J L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p667-1d38dad814911bfad87dba014101c530661911d5b9131feeafb379426595f00c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Antiinfectives and antibacterials</topic><topic>Candida albicans</topic><topic>Cations</topic><topic>Coordination compounds</topic><topic>Derivatives</topic><topic>Enterococcus faecalis</topic><topic>Escherichia coli</topic><topic>Pseudomonas aeruginosa</topic><topic>Silver</topic><topic>Staphylococcus aureus</topic><topic>Tryptophan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smolenski, Piotr</creatorcontrib><creatorcontrib>Pettinari, Claudio</creatorcontrib><creatorcontrib>Marchetti, Fabio</creatorcontrib><creatorcontrib>Silva, M Fatima C Guedesda</creatorcontrib><creatorcontrib>Lupidi, Giulio</creatorcontrib><creatorcontrib>Patzmay, Gretta Veronica Badillo</creatorcontrib><creatorcontrib>Petrelli, Dezemona</creatorcontrib><creatorcontrib>Vitali, Luca A</creatorcontrib><creatorcontrib>Pombeiro, Armando J L</creatorcontrib><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Inorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smolenski, Piotr</au><au>Pettinari, Claudio</au><au>Marchetti, Fabio</au><au>Silva, M Fatima C Guedesda</au><au>Lupidi, Giulio</au><au>Patzmay, Gretta Veronica Badillo</au><au>Petrelli, Dezemona</au><au>Vitali, Luca A</au><au>Pombeiro, Armando J L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Syntheses, Structures, and Antimicrobial Activity of New Remarkably Light-Stable and Water-Soluble Tris(pyrazolyl)methanesulfonate Silver(I) Derivatives of N-Methyl-1,3,5-triaza-7-phosphaadamantane Salt - [mPTA]BF sub(4)</atitle><jtitle>Inorganic chemistry</jtitle><date>2015-01-19</date><risdate>2015</risdate><volume>54</volume><issue>2</issue><spage>434</spage><epage>440</epage><pages>434-440</pages><issn>0020-1669</issn><abstract>Two newsilver(I) complexes of formula [Ag(mPTA) sub(4)](Tpms) sub(4)(BF sub(4)) (1) and [Ag(Tpms)(mPTA)] (BF sub(4)) (2) (mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane cation, Tpms = tris(pyrazol-1 yl)methanesulfonate anion) have been synthesized and fully characterized by elemental analyses, super(1)H and super(31)P{ super(1)H} NMR, ESI-MS, and IR spectroscopic techniques. The single-crystal X-ray diffraction study of 1 discloses a noncoordinated nature of the Tpms species, existing as counterions around the highly charged metal center [Ag(mPTA)] super(5+), 1 being the first reported coordination compound bearing a Kappa super(0)-Tpms. 1 features high solubility and stability in water (S sub(25[degrees]C) = 30 mg times mL super(-1)). The two complexes interact with calf thymus DNA via intercalation mode, binding to the BSA with decrease of its tryptophan fluorescence with a static quenching mechanism. The two new silver complexes exhibit significant antibacterial and antifungal activities screened in vitro against the standard strains of Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans.</abstract><doi>10.1021/ic501855k</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-1669 |
| ispartof | Inorganic chemistry, 2015-01, Vol.54 (2), p.434-440 |
| issn | 0020-1669 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1793267777 |
| source | ACS Publications |
| subjects | Antiinfectives and antibacterials Candida albicans Cations Coordination compounds Derivatives Enterococcus faecalis Escherichia coli Pseudomonas aeruginosa Silver Staphylococcus aureus Tryptophan |
| title | Syntheses, Structures, and Antimicrobial Activity of New Remarkably Light-Stable and Water-Soluble Tris(pyrazolyl)methanesulfonate Silver(I) Derivatives of N-Methyl-1,3,5-triaza-7-phosphaadamantane Salt - [mPTA]BF sub(4) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T17%3A51%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Syntheses,%20Structures,%20and%20Antimicrobial%20Activity%20of%20New%20Remarkably%20Light-Stable%20and%20Water-Soluble%20Tris(pyrazolyl)methanesulfonate%20Silver(I)%20Derivatives%20of%20N-Methyl-1,3,5-triaza-7-phosphaadamantane%20Salt%20-%20%5BmPTA%5DBF%20sub(4)&rft.jtitle=Inorganic%20chemistry&rft.au=Smolenski,%20Piotr&rft.date=2015-01-19&rft.volume=54&rft.issue=2&rft.spage=434&rft.epage=440&rft.pages=434-440&rft.issn=0020-1669&rft_id=info:doi/10.1021/ic501855k&rft_dat=%3Cproquest%3E1773834704%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1773834704&rft_id=info:pmid/&rfr_iscdi=true |