Investigation on Temperature-Sensitive Poly (N-Vinylcaprolactam) Modified Calcium Alginate Microspheres
Temperature-sensitive calcium alginate-based microspheres were prepared in two steps. Firstly, free-radical polymerization of temperature-sensitive N-vinylcaprolactam monomer was performed in aqueous solution of sodium alginate, yielding a mixed aqueous solution bearing temperature-sensitivity compo...
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| Veröffentlicht in: | Advanced materials research 2013, Vol.631-632, p.145-149 |
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| creator | Wang, Wen Chao Li, Yin Yin Ma, Xiao Mei Xia, Yan Zhi Xu, Wei Huan Ji, Quan |
| description | Temperature-sensitive calcium alginate-based microspheres were prepared in two steps. Firstly, free-radical polymerization of temperature-sensitive N-vinylcaprolactam monomer was performed in aqueous solution of sodium alginate, yielding a mixed aqueous solution bearing temperature-sensitivity composed of poly(N-vinylcaprolactam), sodium alginate-graft- poly(N-vinylcaprolactam) and sodium alginate. Then temperature-sensitive composite microspheres were prepared by inverse emulsification-crosslinking using the as-prepared solution as water phase, n-hexane as oil phase, Span-85 and Tween-85 as emulsifiers and calcium chloride as crosslinker respectively. The morphology and temperature-sensitivity of the composite microspheres were investigated by scanning electron microscope and turbidity method respectively. The controlled release behavior of the microspheres towards temperature was investigated preliminarily using berberine as a model drug. |
| doi_str_mv | 10.4028/www.scientific.net/AMR.631-632.145 |
| format | Article |
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Firstly, free-radical polymerization of temperature-sensitive N-vinylcaprolactam monomer was performed in aqueous solution of sodium alginate, yielding a mixed aqueous solution bearing temperature-sensitivity composed of poly(N-vinylcaprolactam), sodium alginate-graft- poly(N-vinylcaprolactam) and sodium alginate. Then temperature-sensitive composite microspheres were prepared by inverse emulsification-crosslinking using the as-prepared solution as water phase, n-hexane as oil phase, Span-85 and Tween-85 as emulsifiers and calcium chloride as crosslinker respectively. The morphology and temperature-sensitivity of the composite microspheres were investigated by scanning electron microscope and turbidity method respectively. The controlled release behavior of the microspheres towards temperature was investigated preliminarily using berberine as a model drug.</description><identifier>ISSN: 1022-6680</identifier><identifier>ISSN: 1662-8985</identifier><identifier>EISSN: 1662-8985</identifier><identifier>DOI: 10.4028/www.scientific.net/AMR.631-632.145</identifier><language>eng</language><publisher>Trans Tech Publications Ltd</publisher><subject>Aqueous solutions ; Calcium chloride ; Microspheres ; Polymerization ; Scanning electron microscopy ; Sodium ; Sodium alginate ; Turbidity</subject><ispartof>Advanced materials research, 2013, Vol.631-632, p.145-149</ispartof><rights>2013 Trans Tech Publications Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2235-7923f5296e8e9c2b3a153c8ec3df1ebf94bd5975e2503c6fbdd5338de67ab2e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttps://www.scientific.net/Image/TitleCover/2200?width=600</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids></links><search><creatorcontrib>Wang, Wen Chao</creatorcontrib><creatorcontrib>Li, Yin Yin</creatorcontrib><creatorcontrib>Ma, Xiao Mei</creatorcontrib><creatorcontrib>Xia, Yan Zhi</creatorcontrib><creatorcontrib>Xu, Wei Huan</creatorcontrib><creatorcontrib>Ji, Quan</creatorcontrib><title>Investigation on Temperature-Sensitive Poly (N-Vinylcaprolactam) Modified Calcium Alginate Microspheres</title><title>Advanced materials research</title><description>Temperature-sensitive calcium alginate-based microspheres were prepared in two steps. Firstly, free-radical polymerization of temperature-sensitive N-vinylcaprolactam monomer was performed in aqueous solution of sodium alginate, yielding a mixed aqueous solution bearing temperature-sensitivity composed of poly(N-vinylcaprolactam), sodium alginate-graft- poly(N-vinylcaprolactam) and sodium alginate. Then temperature-sensitive composite microspheres were prepared by inverse emulsification-crosslinking using the as-prepared solution as water phase, n-hexane as oil phase, Span-85 and Tween-85 as emulsifiers and calcium chloride as crosslinker respectively. The morphology and temperature-sensitivity of the composite microspheres were investigated by scanning electron microscope and turbidity method respectively. The controlled release behavior of the microspheres towards temperature was investigated preliminarily using berberine as a model drug.</description><subject>Aqueous solutions</subject><subject>Calcium chloride</subject><subject>Microspheres</subject><subject>Polymerization</subject><subject>Scanning electron microscopy</subject><subject>Sodium</subject><subject>Sodium alginate</subject><subject>Turbidity</subject><issn>1022-6680</issn><issn>1662-8985</issn><issn>1662-8985</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqVkM1OwzAQhC0EElB4hxwBKWlsx05yLOWvUgsIClfLcTbFKHGK7bTq22NUJM5Iu9o9rGZnPoSucJpkKSnG2-02cUqD8brRKjHgx5PFS8IpjjklCc7YATrBnJO4KAt2GPaUkJjzIj1Gp859pinPMGEnaDUzG3Ber6TXvYlCLaFbg5V-sBC_gnHa6w1Ez327iy4e43dtdq2Sa9u3UnnZXUaLvg4eoI6mslV66KJJu9JGeogWWtnerT_AgjtDR41sHZz_zhF6u7tdTh_i-dP9bDqZx4oQyuK8JLRhpORQQKlIRSVmVBWgaN1gqJoyq2pW5gwIS6niTVXXjNKiBp7LikBGR-hirxscfg0hmei0U9C20kA_OIHzkhJOaPg2Qtf70x-XzkIj1lZ30u4ETsUPZREoiz_KIlAWgbIIlEMTESgHkZu9iLfSOA_qQ3z2gzUh439kvgFOJJJJ</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Wang, Wen Chao</creator><creator>Li, Yin Yin</creator><creator>Ma, Xiao Mei</creator><creator>Xia, Yan Zhi</creator><creator>Xu, Wei Huan</creator><creator>Ji, Quan</creator><general>Trans Tech Publications Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QQ</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>2013</creationdate><title>Investigation on Temperature-Sensitive Poly (N-Vinylcaprolactam) Modified Calcium Alginate Microspheres</title><author>Wang, Wen Chao ; Li, Yin Yin ; Ma, Xiao Mei ; Xia, Yan Zhi ; Xu, Wei Huan ; Ji, Quan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2235-7923f5296e8e9c2b3a153c8ec3df1ebf94bd5975e2503c6fbdd5338de67ab2e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aqueous solutions</topic><topic>Calcium chloride</topic><topic>Microspheres</topic><topic>Polymerization</topic><topic>Scanning electron microscopy</topic><topic>Sodium</topic><topic>Sodium alginate</topic><topic>Turbidity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Wen Chao</creatorcontrib><creatorcontrib>Li, Yin Yin</creatorcontrib><creatorcontrib>Ma, Xiao Mei</creatorcontrib><creatorcontrib>Xia, Yan Zhi</creatorcontrib><creatorcontrib>Xu, Wei Huan</creatorcontrib><creatorcontrib>Ji, Quan</creatorcontrib><collection>CrossRef</collection><collection>Ceramic Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Advanced materials research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Wen Chao</au><au>Li, Yin Yin</au><au>Ma, Xiao Mei</au><au>Xia, Yan Zhi</au><au>Xu, Wei Huan</au><au>Ji, Quan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation on Temperature-Sensitive Poly (N-Vinylcaprolactam) Modified Calcium Alginate Microspheres</atitle><jtitle>Advanced materials research</jtitle><date>2013</date><risdate>2013</risdate><volume>631-632</volume><spage>145</spage><epage>149</epage><pages>145-149</pages><issn>1022-6680</issn><issn>1662-8985</issn><eissn>1662-8985</eissn><abstract>Temperature-sensitive calcium alginate-based microspheres were prepared in two steps. Firstly, free-radical polymerization of temperature-sensitive N-vinylcaprolactam monomer was performed in aqueous solution of sodium alginate, yielding a mixed aqueous solution bearing temperature-sensitivity composed of poly(N-vinylcaprolactam), sodium alginate-graft- poly(N-vinylcaprolactam) and sodium alginate. Then temperature-sensitive composite microspheres were prepared by inverse emulsification-crosslinking using the as-prepared solution as water phase, n-hexane as oil phase, Span-85 and Tween-85 as emulsifiers and calcium chloride as crosslinker respectively. The morphology and temperature-sensitivity of the composite microspheres were investigated by scanning electron microscope and turbidity method respectively. The controlled release behavior of the microspheres towards temperature was investigated preliminarily using berberine as a model drug.</abstract><pub>Trans Tech Publications Ltd</pub><doi>10.4028/www.scientific.net/AMR.631-632.145</doi><tpages>5</tpages></addata></record> |
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| source | Scientific.net Journals |
| subjects | Aqueous solutions Calcium chloride Microspheres Polymerization Scanning electron microscopy Sodium Sodium alginate Turbidity |
| title | Investigation on Temperature-Sensitive Poly (N-Vinylcaprolactam) Modified Calcium Alginate Microspheres |
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