smart pipette for equipment-free separation and delivery of plasma for on-site whole blood analysis

A novel device of smart pipette has been suggested to extract and deliver plasma from whole blood in a disposable format. By operating an on-chip disposable micropump, approximately 30 μL of plasma was obtained from 100 μL of whole blood within 5 min without any external equipment for point-of-care...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2016-02, Vol.408 (5), p.1391-1397
Hauptverfasser:	Im, Sung B, Kim, Sang C, Shim, Joon S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Biochemistry Blood Blood plasma Cell Separation - instrumentation Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Devices Equipment Design Erythrocytes - cytology Food Science Format Gas absorption hematocrit Humans Lab-on-a-chip Laboratory Medicine Mathematical analysis Medical examination Membrane filters Microfluidic Analytical Techniques - instrumentation Microfluidic Analytical Techniques - methods Micropumps Monitoring/Environmental Analysis Physiological aspects Pipettes Plasma Plasma - chemistry Point-of-Care Systems Rapid Communication Separation technology
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Beschreibung
Zusammenfassung:	A novel device of smart pipette has been suggested to extract and deliver plasma from whole blood in a disposable format. By operating an on-chip disposable micropump, approximately 30 μL of plasma was obtained from 100 μL of whole blood within 5 min without any external equipment for point-of-care blood analysis. Graphical Abstract A novel device of smart pipette as a stand-alone lab on a chip (LOC) device has been successfully developed to rapidly extract and deliver 30 μL of plasma within 5 min from 100 μL of whole blood with 45 % hematocrit.
ISSN:	1618-2642 1618-2650
DOI:	10.1007/s00216-015-9259-0