Preparation and evaluation of polyethylenimine-functionalized carbon nanotubes tagged with 5TR1 aptamer for targeted delivery of Bcl-xL shRNA into breast cancer cells

Schematic illustration of targeted shRNA delivery using aptamer-conjugated polyplexes. [Display omitted] •Eight types of nanoparticles were synthesized by covalent attachment of SWCNT to PEG and PEI 10kDa or its derivatives•Fabricated nanoparticles showed better transfection efficiency and less cyto...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2016-04, Vol.140, p.28-39
Hauptverfasser:	Taghavi, Sahar, HashemNia, Azadeh, Mosaffa, Fatemeh, Askarian, Saeedeh, Abnous, Khalil, Ramezani, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	Aptamer Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - genetics bcl-X Protein - genetics bcl-X Protein - metabolism Bcl-xL shRNA Blotting, Western Cell Line, Tumor Cell Survival - genetics Condensing Deoxyribonucleic acid Derivatives Gene Transfer Techniques Genes Humans Mathematical analysis MCF-7 Cells Microscopy, Atomic Force Mucin-1 - genetics Mucin-1 - metabolism Nanotubes, Carbon - chemistry Particle Size Polyetherimides Polyethylene Glycols - chemistry Polyethyleneimine - chemistry Polyethylenimine RNA, Small Interfering - chemistry RNA, Small Interfering - genetics SELEX Aptamer Technique Single wall carbon nanotubes Single-walled carbon nanotubes Targeted gene delivery Transfection - methods Vectors (mathematics)
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