Lack of embryotoxicity of homocysteine thiolactone in mouse embryos in vitro

Recent work from humans and chick embryos has suggested that homocysteine may play a role in producing neural tube defects (NTDs). In an effort to determine if homocysteine is able to produce NTDs in mammalian embryos, mouse embryos were explanted on GD 8 and cultured for 44 h. When either homocyste...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2001-05, Vol.15 (3), p.239-244
Hauptverfasser:	Hansen, Deborah K, Grafton, Thomas F, Melnyk, Stepan, James, S.Jill
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced Amnion - drug effects Animals Biological and medical sciences Cystathionine Dose-Response Relationship, Drug Embryo, Mammalian - drug effects Embryo, Mammalian - metabolism Embryology: invertebrates and vertebrates. Teratology Embryonic and Fetal Development - drug effects Embryotoxicity Female Folic acid Fundamental and applied biological sciences. Psychology Homocysteine Homocysteine - analogs & derivatives Homocysteine - toxicity In Vitro Techniques Mice Microinjections Pregnancy Sulfhydryl Compounds - metabolism Teratogenicity Teratology. Teratogens Toxicity Tests Whole embryo culture
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