Rational design of mirror-like peptides with alanine regulation

To generate effective antimicrobial peptides (AMPs) with good antimicrobial activities and cell selectivity, many synthetic strategies have been implemented to facilitate the development of AMPs. However, these synthetic strategies represent only a small proportion of the methods used for the develo...

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Veröffentlicht in:	Amino acids 2016-02, Vol.48 (2), p.403-417
Hauptverfasser:	Li, Weizhong, Tan, Tingting, Xu, Wei, Xu, Lin, Dong, Na, Ma, Deying, Shan, Anshan
Format:	Artikel
Sprache:	eng
Schlagworte:	alanine Alanine - metabolism Amino Acid Sequence amino acid sequences Amino acids Analytical Chemistry Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - metabolism anti-infective properties Antiinfectives and antibacterials Antimicrobial Cationic Peptides - adverse effects Antimicrobial Cationic Peptides - chemical synthesis Antimicrobial Cationic Peptides - metabolism antimicrobial peptides Bacteria Biochemical Engineering Biochemistry Biomedical and Life Sciences Cell Line Cell Membrane - metabolism Cell Membrane Permeability Circular Dichroism cytotoxicity Drug Design electron microscopy erythrocytes Erythrocytes - drug effects flow cytometry fluorescence emission spectroscopy Gram-negative bacteria Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects HEK293 Cells hemolysis Hemolysis - drug effects Human Humans Hydrophobic and Hydrophilic Interactions hydrophobicity kidney cells Life Sciences Membranes Microbial Sensitivity Tests Neurobiology Original Article Peptides Protein Structure, Secondary Proteomics Selectivity Strategy
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