Targeting transcription factor STAT3 for cancer prevention and therapy
Signal Transducers and Activators of Transcription (STATs) comprise an important class of transcription factors that have been implicated in a wide variety of essential cellular functions related to proliferation, survival, and angiogenesis. Among various STAT members, STAT3 is frequently overexpres...
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| Veröffentlicht in: | Pharmacology & therapeutics (Oxford) 2016-06, Vol.162, p.86-97 |
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| container_title | Pharmacology & therapeutics (Oxford) |
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| creator | Chai, Edna Zhi Pei Shanmugam, Muthu K Arfuso, Frank Dharmarajan, Arunasalam Wang, Chao Kumar, Alan Prem Samy, Ramar Perumal Lim, Lina H K Wang, Lingzhi Goh, Boon Cher Ahn, Kwang Seok Hui, Kam Man Sethi, Gautam |
| description | Signal Transducers and Activators of Transcription (STATs) comprise an important class of transcription factors that have been implicated in a wide variety of essential cellular functions related to proliferation, survival, and angiogenesis. Among various STAT members, STAT3 is frequently overexpressed in tumor cells as well as tissue samples, and regulates the expression of numerous oncogenic genes controlling the growth and metastasis of tumor cells. The current review briefly discusses the importance of STAT3 as a potential target for cancer therapy and also provides novel insights into various classes of existing pharmacological inhibitors of this transcription factor that can be potentially developed as anti-cancer drugs. |
| doi_str_mv | 10.1016/j.pharmthera.2015.10.004 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Pharmacology & therapeutics (Oxford), 2016-06, Vol.162, p.86-97 |
| issn | 0163-7258 1879-016X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Carcinogenesis - metabolism Humans Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - prevention & control Signal Transduction STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - metabolism |
| title | Targeting transcription factor STAT3 for cancer prevention and therapy |
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