A novel adenoviral vector expressing human Fas/CD95/APO-1 enhances p53-mediated apoptosis

Recent evidence suggests an intriguing link between p53 and the Fas pathway. To evaluate this association further, we utilized a recombinant adenoviral vector (AdWTp53) to overexpress wild-type p53 in lung cancer (A549, H23, EKVX and HOP92) and breast cancer (MDA-MB-231 and MCF-7) cell lines and obs...

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Veröffentlicht in:	Cell death and differentiation 1999-04, Vol.6 (4), p.326-333
Hauptverfasser:	Rakkar, A N, Katayose, Y, Kim, M, Craig, C, Ohri, E, Li, Z, Cowan, K H, Seth, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Adenoviridae Infections APO-1 protein Apoptosis - genetics Breast Neoplasms CD95 antigen Cytotoxins - genetics DNA Primers DNA, Neoplasm - analysis Fas antigen fas Receptor - genetics Female Gene Expression Genetic Therapy - methods Genetic Vectors human adenovirus Humans Lung Neoplasms Tumor Cells, Cultured - chemistry Tumor Cells, Cultured - cytology Tumor Cells, Cultured - virology Tumor Suppressor Protein p53 - physiology
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