In silico models for the prediction of dose-dependent human hepatotoxicity

The liver is extremely vulnerable to the effects of xenobiotics due to its critical role in metabolism. Drug-induced hepatotoxicity may involve any number of different liver injuries, some of which lead to organ failure and, ultimately, patient death. Understandably, liver toxicity is one of the mos...

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Veröffentlicht in:	Journal of computer-aided molecular design 2003-12, Vol.17 (12), p.811-823
Hauptverfasser:	Cheng, Ailan, Dixon, Steven L
Format:	Artikel
Sprache:	eng
Schlagworte:	Computer Simulation Data mining Dose-Response Relationship, Drug Hepatotoxicity Humans Liver - drug effects Models, Biological Monte Carlo Method Side effects Toxicology Xenobiotics Xenobiotics - toxicity
Online-Zugang:	Volltext
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