Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-κB

TRAIL (tumour-necrosis factor-related apoptosis ligand or Apo2L) triggers apoptosis through engagement of the death receptors TRAIL-R1 (also known as DR4) and TRAIL-R2 (DR5). Here we show that the c-Rel subunit of the transcription factor NF-κB induces expression of TRAIL-R1 and TRAIL-R2; conversely...

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Veröffentlicht in:	Nature cell biology 2001-04, Vol.3 (4), p.409-416
Hauptverfasser:	Ravi, Rajani, Bedi, Gauri. C., Engstrom, Laura W., Zeng, Qinwen, Mookerjee, Bijoyesh, Gélinas, Céline, Fuchs, Ephraim J., Bedi, Atul
Format:	Artikel
Sprache:	eng
Schlagworte:	Apo2L protein Bcl-Xl protein Biomedical and Life Sciences Cancer Research Cell Biology death receptors Developmental Biology I^KB^a protein Life Sciences NF-^KB protein RelA protein Stem Cells TRAIL protein
Online-Zugang:	Volltext
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